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Respiratory Burst

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Definition: A large increase in oxygen uptake by neutrophils and most types of tissue macrophages through activation of an NADPH-cytochrome b-dependent oxidase that reduces oxygen to a superoxide. Individuals with an inherited defect in which the oxidase that reduces oxygen to superoxide is decreased or absent (GRANULOMATOUS DISEASE, CHRONIC) often die as a result of recurrent bacterial infections.     
See Also Granulomatous Disease, Chronic 		Other names Respiratory Bursts; Oxidative Bursts; Bursts, Respiratory; Bursts, Oxidative; Burst, Respiratory; Oxidative Burst; Burst, Oxidative

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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