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Self Tolerance

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Definition: The normal lack of the ability to produce an immunological response to autologous (self) antigens. A breakdown of self tolerance leads to autoimmune diseases. The ability to recognize the difference between self and non-self is the prime function of the immune system.  a form of immune tolerance   
See Also Autoimmune Diseases; Clonal Anergy; Clonal Deletion
Examples Central Tolerance; Peripheral Tolerance
Other names Tolerances, Self; Tolerance, Self; Self Tolerances

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

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