Definition: Similar to MEN2A, it is also caused by mutations of the MEN2 gene, also known as the RET proto-oncogene. Its clinical symptoms include medullary carcinoma (CARCINOMA, MEDULLARY) of THYROID GLAND and PHEOCHROMOCYTOMA of ADRENAL MEDULLA (50%). Unlike MEN2a, MEN2b does not involve PARATHYROID NEOPLASMS. It can be distinguished from MEN2A by its neural abnormalities such as mucosal NEUROMAS on EYELIDS; LIP; and TONGUE, and ganglioneuromatosis of GASTROINTESTINAL TRACT leading to MEGACOLON. It is an autosomal dominant inherited disease.
coordinate IM with specific endocrine/neoplasm pre-coordinates (IM) + specific histological type (IM) if pertinent
Other names Wagenmann Froboese Syndrome; Syndrome, Wagenmann-Froboese; Neuroma Syndrome, Mucosal; Mucosal Neuroma Syndromes; Wagenmann-Froboese Syndrome; Multiple Endocrine Neoplasms Type 2b; Multiple Endocrine Neoplasia, Type 2b; Mucosal Neuroma Syndrome; MEN2b; MEN IIb; MEN III; MEA IIb; MEA 2b; Neoplasms, Multiple Endocrine Type 2b; Neoplasia, Multiple Endocrine Type 2b; MEN 3; MEN 2b
