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Aphasia, Primary Progressive

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Definition: A progressive form of dementia characterized by the global loss of language abilities and initial preservation of other cognitive functions. Fluent and nonfluent subtypes have been described. Eventually a pattern of global cognitive dysfunction, similar to ALZHEIMER DISEASE, emerges. Pathologically, there are no Alzheimer or PICK DISEASE like changes, however, spongiform changes of cortical layers II and III are present in the TEMPORAL LOBE and FRONTAL LOBE. (From Brain 1998 Jan;121(Pt 1):115-26)  a clinical entity: do not confuse with descriptions of the progression of aphasia in case reports   
Examples Primary Progressive Nonfluent Aphasia 		Other names Syndrome, Mesulam's; Syndrome, Mesulam; Progressive Aphasias, Primary; Progressive Aphasia, Primary; Primary Progressive Aphasias; Primary Progressive Aphasia; Aphasias, Primary Progressive; Mesulam's Syndrome; Mesulam Syndrome

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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