Definition: The joining of RNA from two different genes. One type of trans-splicing is the "spliced leader" type (primarily found in protozoans such as trypanosomes and in lower invertebrates such as nematodes) which results in the addition of a capped, noncoding, spliced leader sequence to the 5' end of mRNAs. Another type of trans-splicing is the "discontinuous group II introns" type (found in plant/algal chloroplasts and plant mitochondria) which results in the joining of two independently transcribed coding sequences. Both are mechanistically similar to conventional nuclear pre-mRNA cis-splicing. Mammalian cells are also capable of trans-splicing.
note category: a physiol process taking place within the cell nucleus; do not confuse with DNA, RECOMBINANT; CLONING, MOLECULAR; or GENETIC ENGINEERING
See AlsoRNA, Spliced Leader
Other names Trans-Splicings, RNA; Splicing, Trans; RNA Trans Splicing; RNA Splicing, Trans; Trans Splicing; Trans RNA Splicing; RNA Trans-Splicing
