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Estrogenic Steroids, Alkylated

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Definition: Estrogenic STEROIDS with aliphatic hydrocarbon chain substitution on C17 or other position. 17-alpha-ALKYLATION renders the molecule more stable, resistant to metabolic degradation, and improves oral efficacy. Examples of synthetic alkyl estrogens include ETHINYL ESTRADIOL and MESTRANOL. Substitutions at other sites generates antiestrogenic and cytotoxic properties.     
Pharmacological Action Estrogens
Examples Ethinyl Estradiol 		Other names Alkylated Estrogenic Steroids; Alkyl Estrogenic Steroids

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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