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Metabolic Detoxication, Phase I

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Definition: Functionalization of exogenous substances to prepare them for conjugation in PHASE II DETOXIFICATION. Phase I enzymes include CYTOCHROME P450 enzymes and some OXIDOREDUCTASES. Excess induction of phase I over phase II detoxification leads to higher levels of FREE RADICALS that can induce CANCER and other cell damage. Induction or antagonism of phase I detoxication is the basis of a number of DRUG INTERACTIONS.     
See Also Drug Interactions 		Other names Oxidative Metabolic Detoxications; Oxidative Metabolic Detoxication; Metabolic Detoxications, Oxidative; Detoxifications, Phase I; Detoxification, Phase I; Detoxications, Oxidative Metabolic; Detoxication, Oxidative Metabolic; Phase I Detoxification; Metabolic Detoxification, Phase I; Metabolic Detoxication, Oxidative

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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