encyclopedia of medical concepts
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Endoplasmic Reticulum-Associated Degradation
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Definition
: A degradation process whereby incorrectly folded proteins are selectively transported out of the ENDOPLASMIC RETICULUM and into the CYTOSOL. The misfolded proteins are subsequently ubiquitinated and degraded by the PROTEASOME.
See Also
Endoplasmic Reticulum Stress
;
Proteolysis
;
Ubiquitination
Other names
Reticulum-
Associated Degradation, Endoplasmic; Pathways, ERAD; Pathway, ERAD; Endoplasmic Reticulum Associated Degradation; Degradation, Endoplasmic Reticulum-
Associated; ERAD Pathways; ERAD Pathway