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7-ketocholesterol
under Ketocholesterols
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Ketocholesterols
Definition
: Cholesterol substituted in any position by a keto moiety. The 7-keto isomer inhibits 3-hydroxy-3-methylglutaryl-CoA reductase activity and inhibits cholesterol uptake in the coronary arteries and aorta in vitro.
/biosyn /physiol permitted
Other names
Oxocholesterols
Substance
CAS Registry & name
Categories
Source
Drugs
*
7-ketocholesterol [ 3beta-hydroxy-5-cholestene-7-one,5-cholesten-3 beta-ol-7-one,7-oxocholesterol ]
inhibits uptake of cholesterol in rabbit aorta
566-28-9 3 beta-
hydroxycholest-
5-
en-
7-
one
*Ketocholesterols
Cholesterol 7-alpha-Hydroxylase/antagonists & inhibitors
Pharma Action
Enzyme Inhibitors
Adv Exp Med Biol 67:419;1976; Adv Exp Med Biol 82:297;1977; Biochim Biophys Acta 486(2):260;1977; Biochim Biophys Acta 529(3):475;1978; Biochim Biophys Acta 531(3):322;1978; Exp Cell Res 109:253;1977; J Biochem (Tokyo) 1980;87(2):497; J Biol Chem 252(15):5186;1977; J Biol Chem 254(3):715;1979; J Mol Cell Cardiol 10:197;1978; Life Sci 11(15):773;1972; Microvasc Res 16(1):51;1978; Proc Soc Exp Biol Med 151(2):303;1976