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Cholesterol 7-alpha-Hydroxylase

More information in Books or onNLM PubMed
Definition: A membrane-bound cytochrome P450 enzyme that catalyzes the 7-alpha-hydroxylation of CHOLESTEROL in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP7, converts cholesterol to 7-alpha-hydroxycholesterol which is the first and rate-limiting step in the synthesis of BILE ACIDS.      Other names Cytochrome P-450 CYP7; CYP7A; CYP7; CYP 7; Cytochrome P 450 CYP7; Cholesterol 7alpha Hydroxylase; Cholesterol 7 alpha Monooxygenase; Cholesterol 7 alpha Hydroxylase; Cholesterol 7 Hydroxylase; Cytochrome P450 7; Cholesterol-7-Hydroxylase; Cholesterol 7alpha-Hydroxylase; Cholesterol 7-alpha-Monooxygenase; CYP 7A
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
CYP7A1 protein, human  EC 1.14.13.17   *Cholesterol 7-alpha-Hydroxylase. DNA Cell Biol. 2010 Oct;29(10):629-37
CYP7A1 protein, rat  EC 1.14.13.17   *Cholesterol 7-alpha-Hydroxylase. J Asian Nat Prod Res. 2008 Jul-Aug;10(7-8):807-12
cytochrome P450 7A1, mouse  EC 1.14.13.17   *Cholesterol 7-alpha-Hydroxylase. Genes Cells 2004 Dec;9(12):1297-308
deoxycholate 7-alpha-hydroxylase  EC 1.14.13.17   *Cholesterol 7-alpha-Hydroxylase. Ann NY Acad Sci 1980;349:399
7-ketocholesterol  566-28-9 3 beta-hydroxycholest-5-en-7-one  *Ketocholesterols Cholesterol 7-alpha-Hydroxylase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors 		Adv Exp Med Biol 67:419;1976; Adv Exp Med Biol 82:297;1977; Biochim Biophys Acta 486(2):260;1977; Biochim Biophys Acta 529(3):475;1978; Biochim Biophys Acta 531(3):322;1978; Exp Cell Res 109:253;1977; J Biochem (Tokyo) 1980;87(2):497; J Biol Chem 252(15):5186;1977; J Biol Chem 254(3):715;1979; J Mol Cell Cardiol 10:197;1978; Life Sci 11(15):773;1972; Microvasc Res 16(1):51;1978; Proc Soc Exp Biol Med 151(2):303;1976

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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