leukocyte endogenous mediator (definition)

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leukocyte endogenous mediator

under Interleukin-1

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Definition: A soluble factor produced by MONOCYTES; MACROPHAGES, and other cells which activates T-lymphocytes and potentiates their response to mitogens or antigens. Interleukin-1 is a general term refers to either of the two distinct proteins, INTERLEUKIN-1ALPHA and INTERLEUKIN-1BETA. The biological effects of IL-1 include the ability to replace macrophage requirements for T-cell activation.

DF: IL 1 or IL1

Other names IL-1; Lymphocyte-Activating Factor; Lymphocyte Activating Factor; Interleukin 1; Epidermal Cell Derived Thymocyte Activating Factor; T Helper Factor; Macrophage Cell Factor; Interleukin I; Epidermal Cell Derived Thymocyte-Activating Factor

Substance	CAS Registry & name	Categories	Source	Drugs*
leukocyte endogenous mediator [ endogenous pyrogen,leukocyte pyrogen ] low MW protein (10,000-30,000) preparation, induces changes typical of those seen in acute phase of inflammation; prepared from rabbit polymorphonuclear leukocytes	0	Interleukin-1 Leukocytes Neutrophils Pharma Action* Pyrogens	Am J Clin Nutr 30(8):1254;1977; Biochem J 156(1):25;1976; Br J Exp Pathol 1979;60(4):441; Clin Bull 1979;9(2):63; Endocrinology 96(3):651;1975; Infect Immun 22(3):637;1978; J Lab Clin Med 1980;95(4):616; J Pharmacol Exp Therapeut 188(3):516;1974; J Reticuloendothyl Soc 23(4):287;1978; Proc Soc Exp Biol Med 152(4):573;1976; Proc Soc Exptl Biol Med 153:419;1976; Proc Soc Exptl Biol Med 157:669;1978

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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