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Interleukin-1

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Definition: A soluble factor produced by MONOCYTES; MACROPHAGES, and other cells which activates T-lymphocytes and potentiates their response to mitogens or antigens. Interleukin-1 is a general term refers to either of the two distinct proteins, INTERLEUKIN-1ALPHA and INTERLEUKIN-1BETA. The biological effects of IL-1 include the ability to replace macrophage requirements for T-cell activation.  DF: IL 1 or IL1   
See Also Receptors, Interleukin-1
Examples Interleukin-1alpha; Interleukin-1beta 		Other names IL-1; Lymphocyte-Activating Factor; Lymphocyte Activating Factor; Interleukin 1; Epidermal Cell Derived Thymocyte Activating Factor; T Helper Factor; Macrophage Cell Factor; Interleukin I; Epidermal Cell Derived Thymocyte-Activating Factor
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
IL1F9 protein, mouse  0   *Interleukin-1. J Invest Dermatol. 2011 Dec;131(12):2428-37
interleukin 1F6, mouse  0   *Interleukin-1. J Immunol 2009 Sep 15;183(6):4021-30
CK 116  0   *Pyridazines Interleukin-1/antagonists & inhibitors. J Ocul Pharmacol Ther 2006 Feb;22(1):19-25
CK 112  0   *Pyridazines Interleukin-1/antagonists & inhibitors. J Ocul Pharmacol Ther 2006 Feb;22(1):19-25
IL36G protein, human  0   *Interleukin-1.
IL36B protein, human  0   *Interleukin-1.
IL37 protein, human  0   *Interleukin-1.
IL36A protein, human  0   *Interleukin-1.
IL-1F8 protein, mouse  0   *Interleukin-1. Cytokine 2005 Mar 21;29(6):245-50
interleukin-1 homolog F5, mouse  0   *Interleukin-1. Biochemistry 2003 Sep 23;42(37):10938-44-
ajulemic acid  0   Tetrahydrocannabinol/*analogs & derivatives Interleukin-1/antagonists & inhibitors. Biol Reprod 2002 Oct;67(4):649-55
interleukin-1 homolog 4, human  0   *Interleukin-1. J Immunol 2003 Jan 1;170(1):107-13
1-(4-chlorocinnamyl)-3,4-bis(4-methoxyphenyl)-1H-pyridazin-6-one  0   *Pyridazines Interleukin-1/antagonists & inhibitors. Bioorg Med Chem Lett 2001 Sep 3;11(17):2373-5
6-(2,3,4,5,6-pentafluorophenoxy)-3,4-bis(4-methoxyphenyl)pyridazine  0   *Pyridazines Interleukin-1/antagonists & inhibitors. Bioorg Med Chem Lett 2001 Sep 3;11(17):2369-72
interleukin-1 epsilon  0   *Interleukin-1. J Immunol 2001 Aug 1;167(3):1440-6
interleukin-1 delta  0   *Interleukin-1. J Immunol 2001 Aug 1;167(3):1440-6
IL1F10 protein, human  0   *Interleukin-1. J Biol Chem 2001 Jun 8;276(23):20597-602
TJU 103  0   *Organic Chemicals Interferon-gamma/antagonists & inhibitors Interleukin-1/antagonists & inhibitors Tumor Necrosis Factor-alpha/antagonists & inhibitors Interleukin-6/antagonists & inhibitors. Antimicrob Agents Chemother 2000 Apr;44(4):1067-9
CK 122  0   *Isoflavones Interleukin-1. Chung Kuo Yao Li Hsueh Pao 1998 Jul;19(4):304-8
CK 119  0   *Pyridazines Interleukin-1. Chung Kuo Yao Li Hsueh Pao 1998 Jul;19(4):304-8
4-benzylidenehydrazino-6-methyl-2-pyrone  0   *Hydrazines *Pyridazines Interleukin-1/antagonists & inhibitors. J Ocul Pharmacol Ther 1998 Aug;14(4):375-88
5-benzylidenehydrazinopyridazin-3(2H)-one  0   *Hydrazines *Pyridazines Interleukin-1/antagonists & inhibitors. J Ocul Pharmacol Ther 1998 Aug;14(4):375-88
CGP 47969A  0   *Piperazines Interleukin-1/antagonists & inhibitors Cytokines/antagonists & inhibitors Tumor Necrosis Factor-alpha/antagonists & inhibitors Interleukin-6/antagonists & inhibitors. J Rheumatol 1994 Nov;21(11):1992-7
U 27391  106314-87-8   *Hydroxamic Acids *Oligopeptides Interleukin-1/antagonists & inhibitors. Ann Rheum Dis 1993 Jan;52(1):37-43
interleukin 1 precursor  0   *Interleukin-1 *Protein Precursors. J Immunol 1985;134(1):343
leukocyte endogenous mediator  0   *Interleukin-1 Leukocytes Neutrophils.
Pharma Action Pyrogens 		Am J Clin Nutr 30(8):1254;1977; Biochem J 156(1):25;1976; Br J Exp Pathol 1979;60(4):441; Clin Bull 1979;9(2):63; Endocrinology 96(3):651;1975; Infect Immun 22(3):637;1978; J Lab Clin Med 1980;95(4):616; J Pharmacol Exp Therapeut 188(3):516;1974; J Reticuloendothyl Soc 23(4):287;1978; Proc Soc Exp Biol Med 152(4):573;1976; Proc Soc Exptl Biol Med 153:419;1976; Proc Soc Exptl Biol Med 157:669;1978

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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