encyclopedia of medical concepts
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compactin

under Lovastatin
More information in Books or onNLM PubMed
More on Lovastatin Definition: A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver.      Other names Mevinolin; Lovastatin, 1 alpha-Isomer; alpha-Isomer Lovastatin, 1; MK803; MK 803; Lovastatin, 1 alpha Isomer; 6 Methylcompactin; 1 alpha-Isomer Lovastatin; Monacolin K; Mevacor; MK-803; Lovastatin, (1 alpha(S*))-Isomer; 6-Methylcompactin Drugs: LOVASTATINMEVACOR; ALTOPREV;
SubstanceCAS Registry & nameCategoriesSourceDrugs*
compactin [ 6-demethylmevinolin,CS 500,ML 236B,ML-236B,ML236B,mevastatin ]
  antifungal metabolite from Penicillium brevicopactum; potent inhibitory activity to sterol synthesis; structure 		73573-88-3 7-(1,2,6,7,8,8a-hexahydro-2-methyl-8- (2-methylbutyryloxy)naphthyl)-3-hydroxyheptan-5-olide  Lovastatin/*analogs & derivatives
Pharma Action Anti-Bacterial Agents; Anticholesteremic Agents; Antifungal Agents; Hydroxymethylglutaryl-CoA Reductase Inhibitors 		Atherosclerosis 1980;35(3):259; Biochim Biophys Acta 1979;575(2):266; Biochim Biophys Acta 489(1):120;1977; Eur J Biochem 77:31;1977; Eur J Biochem 87(2):313;1978; J Antibiotics 29(12):1346;1976; J Biol Chem 1980;255(8):3715; J Biol Chem 253(4):1121;1978; J Chem Soc Perkin I 11:1165;1976; Jpn J Med Sci Biol 31(3):225;1978; Lancet 2(8104/5):1342;1978; Proc Natl Acad Sci USA 1979;76(11):5709

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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