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Hydroxymethylglutaryl-CoA Reductase Inhibitors
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Definition
: Compounds that inhibit HMG-CoA reductases. They have been shown to directly lower cholesterol synthesis.
X ref STATINS, HMG-COA: do not confuse with statin protein in SCR
See Also
Hydroxymethylglutaryl CoA Reductases
Other names
Statins, HMG CoA; Reductase Inhibitors, Hydroxymethylglutaryl-
CoA; Reductase Inhibitors, HMG-
CoA; Inhibitors, Hydroxymethylglutaryl-
CoA Reductase; Inhibitors, Hydroxymethylglutaryl Coenzyme A; Inhibitors, Hydroxymethylglutaryl CoA; Inhibitors, HMG CoA Reductase; Hydroxymethylglutaryl-
Coenzyme A Inhibitors; Hydroxymethylglutaryl-
CoA Inhibitors; Hydroxymethylglutaryl CoA Reductase Inhibitors; HMG-
CoA Statins; HMG CoA Reductase Inhibitors; Inhibitors, Hydroxymethylglutaryl-
Coenzyme A; Inhibitors, Hydroxymethylglutaryl-
CoA; Inhibitors, HMG-
CoA Reductase; Statins, HMG-
CoA; HMG-
CoA Reductase Inhibitors
Substances having this pharmacologic action:
Pravastatin
;
Meglutol
;
Simvastatin
;
Lovastatin
;
compactin
;
pitavastatin
;
red yeast rice
;
rosuvastatin
;
amlodipine, atorvastatin drug combination
;
cerivastatin
;
atorvastatin
;
fluvastatin
Substance
CAS Registry & name
Categories
Source
Drugs
*
Tocomin
0
*Tocotrienols
Hydroxymethylglutaryl-CoA Reductase Inhibitors.
Phytother Res. 2011 Nov;25(11):1586-95
7-
(4-
((3-
fluorobenzyl)carbamoyl)-
5-
cyclopropyl-
2-
(4-
fluorophenyl)-
1H-
imidazol-
1-
yl)-
3,5-
dihydroxyheptanoic acid
0
*Heptanoic Acids
*Imidazoles
Hydroxymethylglutaryl-CoA Reductase Inhibitors.
Bioorg Med Chem Lett 2011 May 1;21(9):2725-31
coenzyme Q10
303-98-0
Ubiquinone/*analogs & derivatives
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Electron Transport Chain Complex Proteins.
Pharma Action
Vitamins
Biochem Biophys Res Commun 1980;93(2):409; Biochim Biophys Acta 462:501;1977; Biokhimiia 1979;44(10):1884; J Biol Chem 1980;255(8):3278