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Pravastatin

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Definition: An antilipemic fungal metabolite isolated from cultures of Nocardia autotrophica. It acts as a competitive inhibitor of HMG CoA reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES).     
Pharmacological Action Anticholesteremic Agents; Hydroxymethylglutaryl-CoA Reductase Inhibitors 		Other names Eptastatin; Sodium Salt, Pravastatin; SQ31000; SQ31,000; SQ 31000; SQ 31,000; RMS431; RMS 431; Pravastatin tert Octylamine Salt; Nu Pravastatin; Lin Pravastatin; CS514; CS 514; Apo Pravastatin; Squibb Brand of Pravastatin Sodium; Selektine; Sankyo Brand of Pravastatin Sodium; SQ-31000; SQ-31,000; RMS-431Drugs* : PRAVASTATIN SODIUM; PRAVACHOL; PRAVIGARD PAC (COPACKAGED)
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
1,2,6,7,8,8a-hexahydro-beta,delta,6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-1-naphthaleneheptanoic acid 4-(nitrooxy)butyl ester  0   *Nitrates Pravastatin/*analogs & derivatives. J Pharmacol Exp Ther 2007 Jan;320(1):419-26
R-416 (pravastatin metabolite)  0   Pravastatin/*analogs & derivatives. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Feb 25;816(1-2):73-9
pravastatin dihydrodiol  124409-20-7   Pravastatin/*analogs & derivatives. Xenobiotica 1992 May;22(5):487-9
dihydroeptastatin  138505-91-6   Pravastatin/*analogs & derivatives. J Med Chem 1992 Sep 4;35(18):3388-93
SQ 31945  135690-31-2   Pravastatin/*analogs & derivatives. J Clin Pharmacol 1992 Feb;32(2):124-32
SQ 31906  145842-18-8 1-Naphthaleneheptanoic acid, 1,2,3,7,8,8a-hexahydro-beta,delta,3-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-, (1S-(1alpha(betaS*,deltaS*),2alpha,3alpha,8beta(R*),8aalpha))  Pravastatin/*analogs & derivatives. J Clin Pharmacol 1992 Feb;32(2):124-32

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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