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Hydroxymethylglutaryl CoA Reductases

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Definition: Enzymes that catalyze the reversible reduction of alpha-carboxyl group of 3-hydroxy-3-methylglutaryl-coenzyme A to yield MEVALONIC ACID.     
See Also Hydroxymethylglutaryl-CoA Reductase Inhibitors
Examples Hydroxymethylglutaryl-CoA Reductases, NAD-Dependent; Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent 		Other names Reductase, 3-Hydroxy-3-methylglutaryl CoA; CoA Reductase, 3-Hydroxy-3-methylglutaryl; 3 Hydroxy 3 methylglutaryl CoA Reductase; Hydroxymethylglutaryl CoA Reductase; HMG CoA Reductase; 3-Hydroxy-3-methylglutaryl CoA Reductase; HMG CoA Reductases
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
HMGCR protein, human  EC 1.1.1.-   *Hydroxymethylglutaryl CoA Reductases. DNA Cell Biol. 2010 Oct;29(10):629-37
HMG2 protein, S cerevisiae  EC 1.1.1.-   *Hydroxymethylglutaryl CoA Reductases *Saccharomyces cerevisiae Proteins. J Biol Chem 2009 May 29;284(22):14710-22
7-(4-(4-fluorophenyl)-6-isopropyl-2-(methyl(1-methyl-1H-1,2,4-triazol-5-yl)amino)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid  0   *Pyrimidines *Triazoles Hydroxymethylglutaryl CoA Reductases. J Med Chem 2008 May 8;51(9):2722-33
7-(2-(4-fluorophenyl)-4-isopropyl-5-(4-methylbenzylcarbamoyl)-2H-pyrazol-3-yl)-3,5-dihydroxyheptanoic acid  0   *Heptanoic Acids *Pyrazoles Hydroxymethylglutaryl CoA Reductases. J Med Chem 2008 Jan 10;51(1):31-45
3,4-dihydroxyphenylpropionylleucinamide  0   *Caffeic Acids Leucine/*analogs & derivatives Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors. J Biochem Mol Toxicol 2005;19(1):25-31
2-(2-(3-hydroxy-12-(2-methyl-1-oxobutoxy)-5-androstan-17-yl)ethyl)tetrahydro-4-hydroxy-2H-pyran-6-one  159014-70-7   *Androstanols *Pyrones Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors. J Med Chem 1994 Sep 30;37(20):3240-6
GR 95030X  0   *Imidazoles Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors. Hum Exp Toxicol 1994 May;13(5):357-68
7-(3-hydroxy-2-methyl-1,2,3,5,6,7,8,8a-octahydro-1-naphtalenyl)-3,5-dihydroxyheptanoic acid  154417-69-3   *Naphthols Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors. J Antibiot (Tokyo) 1994 Jan;47(1):108-9
7-(7-((1,1'-biphenyl-4-yl)methyl)-2-(4-fluorophenyl)-4,5,6,7-tetrahydro-2H-indazol-3-yl)-3,5-dihydroxy-6-heptenoic acid  153321-50-7   *Hydroxy Acids *Indazoles Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors. J Med Chem 1993 Nov 12;36(23):3674-85
7-(3-bromo-4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-pyrrol-1-yl)-3,5-dihydroxy-6-heptenoic acid methyl ester  151106-12-6   *Hydroxy Acids *Pyrroles Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors. J Med Chem 1993 Nov 12;36(23):3658-62
3-hydroxy-25,26,26,26,27,27,27-heptafluoro-5-cholest-8(14)-en-15-one  153463-20-8   *Cholestenones Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors. J Lipid Res 1993 Oct;34(10):1805-23
PD 123244-15  148750-02-1 1H-Pyrrole-1-heptanoic acid, 3,4-dibromo-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-, monosodium salt, (R*,R*)-(+-)  *Pyrroles Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors. Toxicol Pathol 1992;20(4):595-602
chrysosporin  149175-49-5 Chrysosporin  *Organic Chemicals Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors. J Antibiot (Tokyo) 1993 Jul;46(7):1170-2
crilvastatin  120551-59-9   Proline/*analogs & derivatives Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors. Eur J Pharmacol 1993 Apr 22;235(1):59-68
GR 92549  144501-27-9 6-Heptenoic acid, 7-(4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl)-3,5-dihydroxy-, (R*,S*-(E))-(+-)  *Imidazoles Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors. Xenobiotica 1992 Jul;22(7):789-98
3,24-dihydroxycholest-8(14)-en-15-one  120171-12-2   *Cholestenones Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors. J Lipid Res 1992 Oct;33(10):1503-15
3-hydroxycholest-8(14),24-dien-15-one  144535-22-8   *Cholestenones Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors. J Lipid Res 1992 Oct;33(10):1503-15
6-(2,4-dichlorophenyl)-erythro-2,4-dihydroxyhexylphosphonic acid  141263-54-9   *Organophosphorus Compounds Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors. Carbohydr Res 1992 Mar 2;225(2):269-78
6-(2,4-dichlorophenyl)-2,4-dihydroxyhexane-1-sulfonic acid  141263-69-6   *Sulfonic Acids Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors. Carbohydr Res 1992 Mar 2;225(2):269-78
7-(2,4-dichlorophenyl)-3-hydroxy-5-heptanolide  90761-31-2   *Lactones Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors. Carbohydr Res 1992 Mar 2;225(2):269-78
6-(2,4-dichlorophenyl)-2,3,4-trihydroxyhexanesulfonic acid  141240-46-2   *Sulfonic Acids Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors. Carbohydr Res 1992 Mar 2;225(2):247-67
2,6,7-trideoxy-7-C-(2,4-dichlorophenyl)heptonic acid  141267-47-2   *Heptanoic Acids Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors. Carbohydr Res 1992 Mar 2;225(2):247-67
RP 61969  126059-69-6 1(2H)-Isoquinolinone, 4-(4-fluorophenyl)-2-(1-methylethyl)-3-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethenyl)-, (2S-(2alpha(E),4beta))  *Isoquinolines *Pyrans Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors. J Chromatogr 1992 Mar 27;575(2):319-24
3-hydroxy-24-dimethylaminochol-8(14)-en-15-one  136320-61-1   *Cholenes Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors. Chem Phys Lipids 1991 Nov ;60(1):61-9
3,25-dihydroxycholest-8(14)-en-15-one  120185-34-4   *Cholestenones Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors. J Med Chem 1992 Feb 21;35(4):793-5
pannorin  137023-81-5 2H-Naphtho(1,2-b)pyran-2-one, 4,8,10-trihydroxy-5-methyl  *Naphthols *Pyrones Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors. J Antibiot (Tokyo) 1991;44(7):762
6-(2-(8-((4-fluorobenzyl)oxy)-1,2,6,7,8,8a-hexahydro-2,6-dimethyl-1-naphthyl)ethyl)-4-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one  79691-18-2   Lovastatin/*analogs & derivatives Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors. J Med Chem 1991;34(8):2474
L 669262  130468-11-0 Butanoic acid, 2,2-dimethyl-, 1,2,6,7,8,8a-hexahydro-3,7-dimethyl-6-oxo-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (1S-(1alpha,7beta,8beta(2S*,4S*),8abeta))  Lovastatin/*analogs & derivatives Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors. J Antibiot (Tokyo) 1991;44(3):366
SQ 33600  133983-25-2   *Indoles *Organophosphorus Compounds Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors. J Med Chem 1990;33(11):2952
BMY 21950  131177-45-2   *Fatty Acids, Unsaturated *Tetrazoles Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors. Biochem Biophys Res Commun 1990;170(2):726
L 647318  87770-13-6 Butanoic acid, 2,2-dimethyl-, decahydro-3,7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (1S-(1alpha,3alpha,4aalpha,7beta,8beta(2S*,4S*),8abeta))  Lovastatin/*analogs & derivatives Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors. Pharm Res 1990;7(3):289
L 157012  114801-27-3 Butanoic acid, 2,2-dimethyl-, 1,2,3,7,8,8a-hexahydro-3-(hydroxymethyl)-7-methyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (1S-(1alpha,3beta,7beta,8beta(2S*,4S*),8abeta))  Lovastatin/*analogs & derivatives Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors. Pharm Res 1990;7(3):289
simvastatin acid  121009-77-6 1-Naphthaleneheptanoic acid, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-beta,delta-dihydroxy-2,6-dimethyl-, (1S-(1alpha(betaS*,deltaS*),2alpha,6beta,8beta,8aalpha))  Simvastatin/*analogs & derivatives Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors. Exp Eye Res 1990;50(1):65
L 645164  85493-98-7   *Biphenyl Compounds *Pyrones Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors. Exp Eye Res 1990;50(1):65
HR 780  122254-45-9   *Pyridines Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors. J Med Chem 1990;33(1):52
cholest-8-ene-3,15-diol  73390-02-0   *Cholestenes Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors. J Lipid Res 1989;30(6):919
lanost-8-en-3-ol-24-one  80799-31-1   Lanosterol/*analogs & derivatives Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors. Chem Phys Lipids 1988;48(3-4):255
7-(2'-((2''-methyl-1''-oxobutoxy)methyl)-1'-cyclohexyl)-3-hydroxy-5-oxoheptanoic acid  117678-63-4   *Cyclohexanes *Keto Acids Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors. J Med Chem 1989;32(1):197
SRI 62320  94061-80-0   *Indoles Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors. Circulation 1987;76(3):534
phenicin  128-68-7   *Benzoquinones Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors. J Antibiot (Tokyo) 1987;40(2):224
methoxypolyethoxylated cholesterol  99559-58-7   Cholesterol/*analogs & derivatives Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors. Biochim Biophys Acta 1985;837(2):163
6-(2-(2,4-dichloro-6-hydroxyphenyl)ethyl)-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-one  95465-60-4   *Pyrones Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors. Biochemistry 1985;24(6):1364
fermodulin  0   *Metalloproteins Ferrous Compounds Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors. Indian J Biochem Biophys 1984;21(1):27
mevinolinic acid  77285-87-1   Lovastatin/*analogs & derivatives Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors. Teratology 1983;28(3):449
6-hydroxyisocompactin  85798-96-5 Butanoic acid, 2-methyl-, 1,2,6,7,8,8a-hexahydro-6-hydroxy-7-methyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester  Lovastatin/*analogs & derivatives Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors. J Antibiot (Tokyo) 1983;36(7):918
dihydrocompactin  78366-44-6 Butanoic acid, 2-methyl-, 1,2,3,4,4a,7,8,8a-octahydro-7-methyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (1S-(1alpha(R*),4aalpha,7beta,8beta(2S*,4S*),8abeta))  Lovastatin/*analogs & derivatives Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors. J Antibiot (Tokyo) 1981;34(5):614
dihydromevinolin  77517-29-4 Butanoic acid, 2-methyl-, 1,2,3,4,4a,7,8,8a-octahydro-3,7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (1S-(1alpha(R*),3alpha,4aalpha,7beta,8beta(2S*,4S*),8abeta))  Lovastatin/*analogs & derivatives Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors. J Antibiot (Tokyo) 1981;34(5):507
phosphoadenosine diphosphoribose  13552-81-3 adenosine 5'-(trihydrogen diphosphate), 2'-(dihydrogen phosphate), 5'-5'- ester with beta-D-ribofuranose  Adenosine Diphosphate Ribose/*analogs & derivatives Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors. Biochem Biophys Res Commun 89(3):988;1979; Eur J Biochem 98(1):195;1979

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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