encyclopedia of medical concepts
ψ
Pyrimidines
More information
in Books
or on
Definition
: A family of 6-membered heterocyclic compounds occurring in nature in a wide variety of forms. They include several nucleic acid constituents (CYTOSINE; THYMINE; and URACIL) and form the basic structure of the barbiturates.
Examples
Buspirone
;
Dipyridamole
;
Epirizole
;
Fursultiamin
;
Hexetidine
;
Minoxidil
;
Mopidamol
;
Morantel
;
Nicarbazin
;
Oxypurinol
;
Pyrantel
;
Pyrimethamine
;
Pyrimidine Nucleosides
;
Pyrimidine Nucleotides
;
Pyrimidinones
;
Pyrithiamine
;
Thiamine
;
Trapidil
;
Trimethoprim
Substance
CAS Registry & name
Categories
Source
Drugs
*
1-
(7-
(2-
amino-
6-
(4-
methylpiperazin-
1-
yl)pyrimidin-
4-
yl)-
3,4-
dihydroisoquinolin-
2(1H)-
yl)-
2-
cyclopentylethanone
0
*Isoquinolines
*Pyrimidines
Histamine Antagonists.
Eur J Pharmacol. 2012 Jan 30;675(1-3):47-56.
(1H-
indol-
2-
yl)(4-
(phenylamino)thieno(2,3-
d)pyrimidin-
6-
yl)methanone
0
*Indoles
*Pyrimidines.
Bioorg Med Chem. 2012 Jan 1;20(1):125-36
3,4-
dihydro-
2-
(4-
chlorophenyl)-
6-
(4-
methoxyphenyl)-
4-
oxo-
pyrimidine-
5-
carbonitrile
0
*Nitriles
*Pyrimidines.
Molecules. 2012;17(1) (dup#13):809-19
3,4-
dihydro-
2-
phenyl-
6-
para-
fluorophenyl-
4-
oxo-
pyrimidine-
5-
carbonitrile
0
*Nitriles
*Pyrimidines.
Molecules. 2012;17(1) (dup#13):809-19
(4-
(3-
chloro-
4-
fluorophenylamino)thieno(2,3-
d)pyrimidin-
6-
yl)(5-
hydroxy-
1H-
indol-
2-
yl)methanone
0
*Indoles
*Pyrimidines.
Bioorg Med Chem. 2012 Jan 1;20(1):125-36
(4-
(3-
chlorophenylamino)thieno(2,3-
d)pyrimidin-
6-
yl)(1H-
indol-
2-
yl)methanone
0
*Indoles
*Pyrimidines.
Bioorg Med Chem. 2012 Jan 1;20(1):125-36
8-
amino-
3-
(2,3-
dihydroxypropyl)imidazo(4',5'-
5,6)pyrido(2,3-
d)pyrimidine
0
*Imidazoles
*Pyrimidines.
Bioorg Med Chem. 2012 Jan 1;20(1):16-24
2-
amino-
8-
(2-
morpholinoethoxy)-
4-
phenyl-
5H-
indeno(1,2-
d)pyrimidin-
5-
one
0
*Indenes
*Pyrimidines
Adenosine A1 Receptor Antagonists
Adenosine A2 Receptor Antagonists.
J Med Chem. 2012 Feb 9;55(3):1402-17.
2-
amino-
8-
(4-
methylpiperazine-
1-
carbonyl)-
4-
phenyl-
5H-
indeno(1,2-
d)pyrimidin-
5-
one
0
*Indenes
*Pyrimidines
Adenosine A1 Receptor Antagonists
Adenosine A2 Receptor Antagonists.
J Med Chem. 2012 Feb 9;55(3):1402-17.
WZ4002
0
*Acrylamides
*Pyrimidines
Receptor, Epidermal Growth Factor/antagonists & inhibitors.
Lab Invest. 2012 Mar;92(3):371-83.
5-
(3-
ethyl-
1,2,4-
oxadiazol-
5-
yl)-
1,4,5,6-
tetrahydropyrimidine
0
*Oxadiazoles
*Pyrimidines
Muscarinic Agonists
Receptor, Muscarinic M1/agonists.
J Pharmacol Exp Ther. 2012 Mar;340(3):588-94.
4-
(3-
(2H-
1,2,3-
triazol-
2-
yl)phenylamino)-
2-
(2-
aminocyclohexylamino)pyrimidine-
5-
carboxamide
0
*Cyclohexylamines
*Pyrimidines.
J Pharmacol Exp Ther. 2012 Feb;340(2):350-9.
pirafen
0
*Phosphinic Acids
*Pyrimidines
Plant Growth Regulators.
Dokl Biochem Biophys. 2011 Nov-Dec;441():283-6
2-
amino-
7-
(4-
fluoro-
2-
(6-
methoxypyridin-
2-
yl)phenyl)-
4-
methyl-
7,8-
dihydropyrido(4,3-
d)pyrimidin-
5(6H)-
one
0
*Pyridones
*Pyrimidines
HSP90 Heat-Shock Proteins/antagonists & inhibitors.
Anticancer Res. 2012 Feb;32(2):453-62.
4-
(3-
(benzyloxy)phenyl)-
2-
(ethylsulfinyl)-
6-
(trifluoromethyl)pyrimidine
0
*Pyrimidines.
Biochem Biophys Res Commun. 2012 Jan 6;417(1):558-63
P3155
0
*Pyridines
*Pyrimidines
Hypoxia-Inducible Factor 1, alpha Subunit/antagonists & inhibitors.
Bioorg Med Chem Lett. 2010 Nov 15;20(22):6426-9.
2-
(4-
(biphenyl-
4-
ylamino)-
6-
chloropyrimidin-
2-
ylthio)octanoic acid
0
*Octanoic Acids
*Pyrimidines
Lipoxygenase Inhibitors.
Br J Pharmacol. 2011 Sep;164(2b):781-93.
2-
amino-
8-
(4-
(2-
hydroxyethoxy)cyclohexyl)-
6-
(6-
methoxypyridin-
3-
yl)-
4-
methylpyrido(2,3-
d)pyrimidin-
7(8H)-
one
0
*Pyridones
*Pyrimidines
Phosphatidylinositol 3-Kinases/antagonists & inhibitors.
Mol Cancer Ther. 2011 Nov;10(11):2189-99.
2-
(difluoro-
((4-
ethylpyrimidinyl)thio)methyl)benzoxazole
0
*Benzoxazoles
*Pyrimidines
Reverse Transcriptase Inhibitors
HIV Reverse Transcriptase.
J Med Chem. 2011 Dec 8;54(23):7974-85.
2-
(1-
(2-
(4-
chlorophenyl)-
5-
methylpyrazolo(1,5-
a)pyrimidin-
7-
yl)-
2-
piperidinyl)ethanol
0
*Pyrazoles
*Pyrimidines
GABA-B Receptor Agonists.
Neuropharmacology. 2011 Oct-Nov;61(5-6):957-66
4,6-
dichloro-
5-
formylpyrimidine
0
*Pyrimidines.
Mol Divers. 2011 Nov;15(4):839-47
1-
(4-
((2-
(2-
aminopyrimidin-
5-
yl)-
7-
methyl-
4-
morpholinothieno(3,2-
d)pyrimidin-
6-
yl)methyl)piperazin-
1-
yl)-
2-
hydroxypropan-
1-
one
0
*Pyrimidines
*Bicyclo Compounds, Heterocyclic
Phosphatidylinositol 3-Kinase/antagonists & inhibitors.
J Med Chem. 2011 Nov 10;54(21):7579-87.
BAY 60-
4552
0
*Pyrazoles
*Pyrimidines
Guanylate Cyclase
Enzyme Activators.
Eur Urol. 2011 Nov;60(5):1020-6.
LP105 compound
0
*Pyrimidines
Lipoxygenase Inhibitors.
Br J Pharmacol. 2011 Aug;163(8):1721-32
PF-
3893787
0
*Pyrimidines
*Pyrrolidines.
Bioorg Med Chem Lett. 2011 Nov 1;21(21):6596-602
YHHU0895
0
*Indoles
*Pyrimidines
Antineoplastic Agents.
Cancer Lett. 2012 Jan 1;314(1):54-62
LY2811376
0
*Pyrimidines
*Thiazines.
J Neurosci. 2011 Nov 16;31(46):16507-16
2-
((6-
(3-
amino-
3-
methylpiperidine-