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Pyrimidinones

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Definition:      
Examples Alloxan; Barbiturates; Cytosine; Lopinavir; Risperidone; Ritanserin; Sparsomycin; Uracil 		Other names Pyrimidones
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
1,6-dimethyl-3-propylpyrimido(5,4-e)(1,2,4)triazine-5,7-dione  0   *Pyrimidinones *Triazines. Mol Pharm. 2011 Dec 5;8(6):2252-61.
LCQ789  0   *Pyrazoles *Pyrimidinones. Drug Dev Ind Pharm. 2012 Feb;38(2):235-47.
5-(4-chloro-phenyl)-1-phenyl-6-(4-pyrazin-2-yl-phenyl)-1,5-dihydro-pyrazolo(3,4-d)pyrimidin-4-one  0   *Pyrazoles *Pyrimidinones. Naunyn Schmiedebergs Arch Pharmacol. 2011 Dec;384(6):565-81
5-(4-chlorophenyl)-3-methyl-2-(2-(((1-methylethyl)amino)methyl)-1-pyrrolidinyl)-6-(4-pyridinyl)-4(3H)-pyrimidinone  0   *Pyrimidinones *Pyrrolidines Mitogen-Activated Protein Kinase 14/antagonists & inhibitors. Drug Metab Dispos. 2011 Sep;39(9):1668-73.
cytimidine  0   *Pyrimidinones. Org Lett. 2011 Oct 7;13(19):5000-3
N-((5-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo(2,3-d)pyrimidin-6-yl)propyl)thiophen-2-yl)carbonyl)glutamic acid  0   *Glutamates *Pyrimidinones. J Med Chem. 2011 Oct 27;54(20):7150-64.
N-(3-aminopropyl)-N-(1-(5-benzyl-3-methyl-4-oxo-(1,2)thiazolo(5,4-d)pyrimidin-6-yl)-2-methylpropyl)-4-methylbenzamide  0   *Benzamides *Pyrimidinones. J Med Chem. 2011 Oct 13;54(19):6734-50.
2-(sec-butylthio)-6-(1-(2,6-difluorophenyl)propyl)-5-methylpyrimidin-4(3H)-one  0   *Pyrimidinones Reverse Transcriptase Inhibitors. J Med Chem. 2011 Aug 25;54(16):5927-36.
1-(4-(1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxypyridazin-3-yl)-2,4-dioxo-1,2,3,4-tetrahydrothieno(2,3-d)pyrimidin-6-yl)phenyl)-3-methoxyurea  0   *Phenylurea Compounds *Pyrimidinones Receptors, LHRH/antagonists & inhibitors. J Med Chem 2011 Jul 28;54(14):4998-5012
ethyl 4-(4'-heptanoyloxyphenyl)-6-methyl-3,4-dihydropyrimidin-2-one-5-carboxylate  0   *Pyrimidinones Calcium Channel Blockers. Biochimie 2011 Jul;93(7):1146-56
5-(ethoxycarbonyl)-6-methyl-4-(4-methoxyphenyl)-3,4-dihydropyrimidin-2(1H)-one  0   *Pyrimidinones. J Pharm Biomed Anal 2011 Jul 15;55(5):1223-6
3-amino-6-(4-chlorophenyl)-8-phenyl-1H-pyrido(2,3-d)(1,2,4)triazolo(4,3-a)pyrimidin-5-one  0   *Pyrimidinones *Triazoles. Eur J Med Chem 2011 Jun;46(6):2031-6
N-(3-(6-(4-(1,4-dimethyl-3-oxopiperazin-2-yl)phenylamino)-4-methyl-5-oxo-4,5-dihydropyrazin-2-yl)-2-methylphenyl)-4,5,6,7-tetrahydrobenzo(b)thiophene-2-carboxamide  0   *Pyrimidinones *Thiophenes. J Pharmacol Exp Ther 2011 Jul;338(1):154-63
NSC 124854  0   *Phosphoric Acid Esters *Pyrimidinones DNA Polymerase beta/antagonists & inhibitors. PLoS One 2011;6(2):e16691
7-aminopyrimido(4,5-d)pyrimidine-2,4(1H,3H)-dione  0   *Pyrimidinones. J Am Chem Soc. 2011 May 11;133(18):6926-9
2-((4-cyanophenylamino)carbonylmethylthio)-6-(2-chloro-6-fluorobenzyl)-5-ethylpyrimidin-4(3H)-one  0   *Pyrimidinones. ChemMedChem. 2011 May 2;6(5):826-33
GSK 1120212  0   *Pyridones *Pyrimidinones MAP Kinase Kinase 1/antagonists & inhibitors MAP Kinase Kinase 2/antagonists & inhibitors. JOP 2011;12(2):114-6
SN 30191  0   *Pyrimidinones Phosphatidylinositol 3-Kinase/antagonists & inhibitors. Int J Pharm 2011 Apr 15;408(1-2):138-51
2-amino-6-methylpyrimidin-4-one  0   *Pyrimidinones. Acta Crystallogr C. 2011 May;67(Pt 5):o179-87
2,6-diaminopyrimidin-4-one  0   *Pyrimidinones. Acta Crystallogr C. 2011 May;67(Pt 5):o179-87
5-amino-8-(2,3,5-tri-O-benzoyl-beta-D-ribofuranosyl)pyrimido(4,5-d)pyrimidine-2,4(3H,8H)-dione  0   *Monosaccharides *Pyrimidinones. Acta Crystallogr C. 2011 May;67(Pt 5):o175-8
4-((3R,4R)-dihydroxypyrrolidino)pyrimidin-2-one  0   *Pyrimidinones. Chem Commun (Camb). 2011 Apr 21;47(15):4424-6
TAK 733  0   *Pyridones *Pyrimidinones. Bioorg Med Chem Lett 2011 Mar 1;21(5):1315-9
2-thiopyrimidine-4-one  0   *Pyrimidinones. Eur J Med Chem. 2011 Feb;46(2):738-42
5-(3-fluoro-4-((6-(methyloxy)-7-((3-(4-morpholinyl)propyl)oxy)-4-quinolinyl)oxy)phenyl)-3-methyl-2-(phenylmethyl)-4(3H)pyrimidinone  0   *Pyrimidinones *Quinolines. J Biol Chem 2008 Feb 1;283(5):2675-83
5-(6-hydroxy-4-oxo-2-thioxo-1,2,3,4-tetrahydroxy-5-pyrimidinyl)-2,4-pentadienylidene-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione  0   *Pyrimidinones *Thiones. J Alzheimers Dis 2011 Jan 1;23(1):37-48
1-acetyl-2,3,6-triisopropyl-tetrahydropyrimidin-4(1H)-one  0   *Pyrimidinones *Pyrroles Alkaloids. Fitoterapia. 2010 Dec;81(8):1091-3
3-isopropyl-tetrahydropyrrolo(1,2-a)pyrimidine-2,4(1H,3H)-dione  0   *Pyrimidinones *Pyrroles Alkaloids. Fitoterapia. 2010 Dec;81(8):1091-3
15b-dehydro-5- N-acetylardeemin  0   *Pyrimidinones Alkaloids. Planta Med. 2010 Oct;76(14):1616-21
JBIR-68  0   *Monosaccharides *Pyrimidinones. Org Lett. 2010 Oct 15;12(20):4664-6
2'-carbethoxy-biphenylylmethyl pyrimidinone  0   *Biphenyl Compounds *Pyrimidinones. Pharmazie. 2010 Nov;65(11):794-800
3-amino-6-(4-chloro-2-hydroxy-5-methylphenyl)-1H-pyrazolo(3,4-d)thiazolo(3,2-a)pyrimidin-4-one  0   *Pyrimidinones *Thiazoles Xanthine Oxidase/antagonists & inhibitors. J Enzyme Inhib Med Chem 2010 Oct;25(5):615-21
3-amino-6-(2-hydroxyphenyl)-1H-pyrazolo(3,4-d)thiazolo(3,2-a)pyrimidin-4-one  0   *Pyrimidinones *Thiazoles Xanthine Oxidase/antagonists & inhibitors. J Enzyme Inhib Med Chem 2010 Oct;25(5):615-21
2-(3,4-dihydroxyphenyl)-6-hydroxypyrido(1,2-a)pyrimidin-4-one  0   *Pyridines *Pyrimidinones Aldehyde Reductase/antagonists & inhibitors. J Pharm Pharmacol 2010 Jan;62(1):107-13
1-(6-ethoxy-5-(3-ethyl-6,7-dihydro-2-(2-methoxyethyl)-7-oxo-2H-pyrazolo(4,3-d)pyrimidin-5-yl)-3-pyridyl sulphonyl)-4-ethylpiperazine  0   *Pyrimidinones *Sulfonamides Cyclic Nucleotide Phosphodiesterases, Type 5. BJU Int 2010 Sep;106(5):666-73
6-amino-2-(2-(4-tert-butylphenoxy)ethylsulfanyl)-1H-pyrimidin-4-one  0   *Pyrimidinones *Sulfides. Cancer Lett 2010 Dec 8;298(2):250-7
1-(1-(3-((6-chloronaphthalen-2-yl)sulfonyl)-2-hydroxypropanoyl)piperidin-4-yl)tetrahydropyrimidin-2(1H)-one  0   *Pyrimidinones *Sulfones Factor Xa/antagonists & inhibitors. J Med Chem 2010 May 13;53(9):3517-31
N-(3-(5-(4-bromo-2-fluorophenylamino)-3-cyclopropyl-8-methyl-2,4,7-trioxo-3,4,7,8-tetrahydro-2H-pyrido(2,3-d)pyrimidin-1-yl)phenyl)methanesulfonamide  0   *Pyrimidinones *Sulfonamides. Cancer Sci 2007 Nov;98(11):1809-16
N'-(2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4(trifluoromethyl)-3,6-dihydro-1(2H)-pyrimidinyl)benzoyl)-N-isopropyl-N-methylsulfamide  0   *Pyrimidinones *Sulfonamides Herbicides. J Agric Food Chem. 2010 Jun 23;58(12):7335-43
9-benzylidene-3-methyl-2-methylsulfanyl-5-phenyl-5,6,7,8,9,10-hexahydropyrimido(4,5-b)quinolin-4(3H)-one  0   *Pyrimidinones *Quinolines. Acta Crystallogr C 2010 Aug;66(Pt 8):o389-91
N-(4-methyl-3-(1-methyl-7-(6-methylpyridin-3-ylamino)-2-oxo-1,2-dihydropyrimido(4,5-d)pyrimidin-3(4H)-yl)phenyl)-3-(trifluoromethyl)benzamide  0   *Pyrimidinones *Bicyclo Compounds, Heterocyclic. J Med Chem 2010 Aug 12;53(15):5439-48
2,5,6-triamiopyrimidin-4-one  0   *Pyrimidinones. PLoS Pathog. 2010;6(4) (dup#3):e1000865
1-(4-aminomethyl-4-(3-chlorophenyl)cyclohexyl)-tetrahydropyrimidin-2-one  0   *Pyrimidinones Dipeptidyl Peptidase 4/antagonists & inhibitors. Drug Metab Dispos 2010 Mar;38(3):361-7
3-amino-7,8-dihydroimidazo-(1,5-c)-pyrimidin-5(6H)-one  0   *Imidazoles *Pyrimidinones. Nat Prod Commun. 2010 Mar;5(3):377-82
2-(3-benzyl-4-oxo-3,4,5,6,7,8-hexahydrobenzo(4,5)thieno(2,3-d)pyrimidin-2-ylsulfanylmethyl)-oxazole-4-carboxylic acid (2-pyrrolidin-1-yl-ethyl)amide  0   *Pyrimidinones *Thiophenes. Biochem Biophys Res Commun 2010 Mar 19;393(4):849-54
PKF118-310  0   *Pyrimidinones *Triazines. Int J Cancer 2010 May 15;126(10):2426-36
2-(4-(3-(5-ethyl-7-n-propyl-3,5-dihydro-4H-pyrrolo(3,2-d)pyrimidin-4-onyl)-4-n-propoxyphenyl)sulfonylpiperazin-1-yl)ethyl hydrogen sulfate  0   *Pyrimidinones *Sulfonamides. Xenobiotica 2010 Feb;40(2):129-37
(1,5-dihydro-5-(5-pyrimidine-2,4(1H,3H)-dionyl)-2H-chromeno(2,3-d)pyrimidine-2,4(3H)-dione)  0   *Benzopyrans *Pyrimidinones. J Phys Chem A. 2010 Jan 14;114(1):97-104
(3Z)-3-(1-((5-methyl-1H-pyrazol-3-yl)amino)ethylidene)-4,5-dihydrofuran-2(3H)-one-6-(2-hydroxyethyl)-2,5-dimethylpyrazolo(1,5-a)pyrimidin-7(4H)-one  0   *Pyrazoles *Pyrimidinones. Acta Crystallogr C. 2010 Jan;66(Pt 1):o25-8
6-amino-2-dimethylamino-3-methyl-5-nitrosopyrimidin-4(3H)-one monohydrate  0   *Pyrimidinones. Acta Crystallogr C. 2009 Nov;65(Pt 11):o549-52
6-amino-3-methyl-5-nitroso-2-(pyrrolidin-1-yl)pyrimidin-4(3H)-one monohydrate  0   *Pyrimidinones. Acta Crystallogr C. 2009 Nov;65(Pt 11):o549-52
pyrrolo(1,2-a)pyrimidin-4(6H)-one  0   *Pyrimidinones *Pyrroles. J Org Chem. 2009 Aug 7;74(15):5699-702
(E)-5-nitro-6-(2-hydroxystyryl)pyrimidine-2,4(1H,3H)-dione  0   *Pyrimidinones. J Org Chem. 2009 Aug 7;74(15):5123-34
2-amino-3-methyl-6-(methyl(phenyl)amino)-5-nitropyrimidin-4(3H)-one  0   *Pyrimidinones. Acta Crystallogr C. 2009 Sep;65(Pt 9):o441-3
3-methyl-7-(2-thienyl)pyrido(2,3-d)pyrimidine-2,4(1H,3H)-dione  0   *Pyrimidinones. Acta Crystallogr C. 2009 Jun;65(Pt 6):o284-6
7-amino-6-cyano-5-(4-(1-piperidinyl)-phenyl)-2-thioxopyrido (2,3- d)pyrimidin-4(1H)-one  0   *Piperidines *Pyrimidinones. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3392-7
6-methylpyrrolo(2,3-d)-2-pyrimidinone  0   *Pyrimidinones *Pyrroles. Mol Biol (Mosk). 2009 May-Jun;43(3):455-63
N-(6-aminohexyl)-3-(1-ethyl-3-methyl-7-oxo-6,7-dihydro-1H-pyrazolo(4,3-d)pyrimidin-5-yl)-4-propoxybenzenesulfonamide  0   *Pyrimidinones *Sulfonamides Cyclic Nucleotide Phosphodiesterases, Type 5/antagonists & inhibitors. Mol Biosyst 2009 May;5(5):472-82
6-amino-3-methyl-5-nitrosopyrimidine-2,4(1H,3H)-dione  0   *Pyrimidinones. Acta Crystallogr C. 2009 May;65(Pt 5):o257-60
thieno(2,3-d)pyrimidin-4-one  0   *Pyrimidinones. J Comb Chem. 2009 May-Jun;11(3):508-14
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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