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Sparsomycin
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Definition
: An antitumor antibiotic produced by Streptomyces sparsogenes. It inhibits protein synthesis in 70S and 80S ribosomal systems.
an antineoplastic antibiotic
Pharmacological Action
Antibiotics, Antineoplastic
;
Protein Synthesis Inhibitors
Substance
CAS Registry & name
Categories
Source
Drugs
*
ethyldeshydroxysparsomycin
119410-38-7
Sparsomycin/*analogs & derivatives.
Anticancer Res 1992 Jan-Feb;12(1):167-70
phenol-
alanine sparsomycin
132337-89-4
Sparsomycin/*analogs & derivatives.
Antimicrob Agents Chemother 1991;35(1):10
n-
pentylsparsomycin
114991-34-3
Sparsomycin/*analogs & derivatives.
Invest New Drugs 1990;8(1):25
MDL 20828
98930-79-1 2-
Propenamide, N-
(2-
hydroxy-
1-
(((4-
hydroxyphenyl)sulfinyl)methyl)ethyl)-
3-
(1,2,3,4-
tetrahydro-
6-
methyl-
2,4-
dioxo-
5-
pyrimidinyl)
Sparsomycin/*analogs & derivatives
Peptide Chain Elongation, Translational
Peptidyl Transferases/antagonists & inhibitors.
Biochem Biophys Res Commun 1990;166(2):673
deshydroxysparsomycin
113597-70-9
Sparsomycin/*analogs & derivatives.
Anticancer Res 1988;8(6):1381
octylsparsomycin
88001-59-6
Sparsomycin/*analogs & derivatives.
J Med Chem 1984;27(3):301
MDL 19152
61786-72-9
Sparsomycin/*analogs & derivatives.
Biochem Biophys Res Commun 1983;114(1):1