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Peptidyl Transferases

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Definition: Acyltransferases that use AMINO ACYL TRNA as the amino acid donor in formation of a peptide bond. There are ribosomal and non-ribosomal peptidyltransferases.     
See Also Peptide Chain Elongation, Translational; Ribosomal Proteins 		Other names Transpeptidases; Peptidyltransferase; Peptidyl Translocases; Translocases, Peptidyl; Transferases, Peptidyl; Peptidyltransferases
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
PBP1a protein, Streptococcus pneumoniae  EC 2.3.2.12   *Bacterial Proteins *Peptidyl Transferases. Acta Crystallogr D Biol Crystallogr. 2003 Jun;59(Pt 6):1067-9
MDL 20828  98930-79-1 2-Propenamide, N-(2-hydroxy-1-(((4-hydroxyphenyl)sulfinyl)methyl)ethyl)-3-(1,2,3,4-tetrahydro-6-methyl-2,4-dioxo-5-pyrimidinyl)  Sparsomycin/*analogs & derivatives Peptide Chain Elongation, Translational Peptidyl Transferases/antagonists & inhibitors. Biochem Biophys Res Commun 1990;166(2):673
blasticidin S  2079-00-7 1-(1'-cytosinyl)-4-(L-3'-amino-5'-(1''-N-methylguanidino)valerylamino)-1,2,3,4-tetradeoxy-beta-D-erythro-hex-2-enuronic acid  Nucleosides Peptidyl Transferases/antagonists & inhibitors.
Pharma Action Anti-Bacterial Agents ; Antifungal Agents ; Enzyme Inhibitors ; Trypanocidal Agents 		BBA 475(1):14;1977; Biochim Biophys Acta 390:192;1975; Can J Microbiol 23(5):626;1977; Environ Qual Safety 5:49;1976; Int J Cancer 20:296;1977; J Antibiot 29(5):595;1976; J Antiobiotics 29(12):1341;1976; J. Antibiotics 30(11):1019;1977; Mol Gen Genetics 154(1):67;1977
amicetin  17650-86-1   Pyrimidine Nucleosides Peptidyl Transferases/antagonists & inhibitors.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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