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Dipeptidyl Peptidase 4

More information in Books or onNLM PubMed
Definition: A serine protease that catalyses the release of an N-terminal dipeptide. Several biologically-active peptides have been identified as dipeptidyl peptidase 4 substrates including INCRETINS; NEUROPEPTIDES; and CHEMOKINES. The protein is also found bound to ADENOSINE DEAMINASE on the T-CELL surface and is believed to play a role in T-cell activation.      Other names Dipeptidyl Peptidase IV; Antigen, CD26; CD26 Antigen; Adenosine Deaminase Complexing Protein 2; Dipeptidyl-Peptidase IV; CD26 Antigens; Antigens, CD26
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
KR 66222  0   *Thiazolidines Valine/*analogs & derivatives Dipeptidyl Peptidase 4. Xenobiotica 2011 Jun;41(6):445-55
glycyl-prolyl-diphenylphosphonic acid  0   *Dipeptides *Phosphonic Acids Dipeptidyl Peptidase 4. Arch Dermatol Res 2010 Dec;302(10):725-31
4-(3-amino-4-(2,4,5-trifluorophenyl)butanoyl)-3-(tert-butoxymethyl)piperazin-2-one  0   *Piperazines Dipeptidyl Peptidase 4. Diabetes Res Clin Pract 2011 Jan;91(1):72-9
lipoyl vildagliptin  0   Adamantane/*analogs & derivatives Thioctic Acid/*analogs & derivatives Dipeptidyl Peptidase 4. Xenobiotica 2010 Oct;40(10):707-12
carmegliptin  0   *Quinolizines Dipeptidyl Peptidase 4. Bioorg Med Chem Lett 2010 Feb 1;20(3):1109-13
6-(aminomethyl)-5-(2,4-dichlorophenyl)-N-(1-ethyl-1H-pyrazol-5-yl)-7-methylimidazo(1,2-a)pyrimidine-2-carboxamide  0   *Imidazoles *Pyrimidines Dipeptidyl Peptidase 4. J Med Chem 2010 Aug 12;53(15):5620-8
4-fluoro-1-(4-fluoro-(4-fluorophenyl)phenylalanyl)-2-pyrrolidinecarbonitrile  0   *Pyrrolidines Phenylalanine/*analogs & derivatives Dipeptidyl Peptidase 4. J Pharm Sci 2010 Jul;99(7):3030-40
Ves v 3 allergen, Vespula vulgaris  0   *Allergens *Dipeptidyl Peptidase 4 Wasp Venoms. J Immunol 2010 May 1;184(9):5403-13
Api m 5 allergen, Apis mellifera  0   *Allergens *Dipeptidyl Peptidase 4 Bee Venoms. J Immunol 2010 May 1;184(9):5403-13
1-(4-aminomethyl-4-(3-chlorophenyl)cyclohexyl)-tetrahydropyrimidin-2-one  0   *Pyrimidinones Dipeptidyl Peptidase 4/antagonists & inhibitors. Drug Metab Dispos 2010 Mar;38(3):361-7
1-(2-(5-cyano-2-pyridinylamino)ethylamino)acetyl-2-pyrrolidinecarbonitrile  0   *Aminopyridines *Pyrrolidines Dipeptidyl Peptidase 4/antagonists & inhibitors. Int J Pharm 2009 Oct 20;381(1):56-61
2-(4-(amino(N-cyclobutyl-N-methylcarbamoyl)methyl)cyclohexylmethoxymethyl)-5-methylbenzoic acid  0   *Benzoic Acids Dipeptidyl Peptidase 4/antagonists & inhibitors. Exp Anim 2009 Jul;58(4):363-74
Dpp4 protein, mouse  EC 3.4.14.5   *Dipeptidyl Peptidase 4.
omega protein, Drosophila  EC 3.4.14.5   *Dipeptidyl Peptidase 4 *Drosophila Proteins. J Insect Sci 2005;5:26
Atrn protein, rat  0   *Membrane Proteins Dipeptidyl Peptidase 4.
P32-98 compound  0   *Pentanoic Acids *Thiazolidines Dipeptidyl Peptidase 4/metabolism. Diabetes 2002 Apr;51(4):943-50
Atrn protein, mouse  0   *Membrane Proteins Dipeptidyl Peptidase 4. Nature 1999 Mar 11;398(6723):148-52
DPP4 protein, human  EC 3.4.14.5   *Dipeptidyl Peptidase 4. Cancer Res 1984;44(10):4688

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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