encyclopedia of medical concepts
ψ 
ψ 
ψ 

Phosphonic Acids

More information in Books or onNLM PubMed
Definition: Inorganic or organic derivatives of phosphonic acid with the general formula ROP(OH)2 or RP(=O)(OH)2. The tautomeric form of this compound (P(OH)3) is PHOSPHOROUS ACIDS. Nucleoside phosphonates have a phosphate-carbon bond that is more resistant to enzymatic cleavage than the normal phosphate-oxygen bond.  do not confuse with PHOSPHINIC ACIDS; for nucleoside phosphonates coordinate with PURINES or PYRIMIDINES    Other names Esters, Phosphonic Acid; Acids, Phosphonic; Acid Esters, Phosphonic; Phosphonic Acid Esters; Phosphonates
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
alpha-hydroxyfarnesylphosphonic acid  0   *Phosphonic Acids Farnesol/*analogs & derivatives. Anticancer Res. 2012 Mar;32(3):831-8.
(1R*,2R*)-1,2-dihydroxy-(1-(13)C(1))propylphosphonic acid  0   *Phosphonic Acids Propane/*analogs & derivatives. Chemistry. 2011 Nov 18;17(47):13341-8
phosphonic acid  13598-36-2   *Phosphonic Acids *Phosphorous Acids.
2-amino-4-((3-(carboxymethyl)phenyl)(methyl)phosphono)butanoic acid  0   *Aminobutyric Acids *Phosphonic Acids gamma-Glutamyltransferase/antagonists & inhibitors. J Pharmacol Exp Ther. 2011 Dec;339(3):945-51.
n-propanephosphonic acid anhydride  0   *Phosphonic Acids Propane/*analogs & derivatives. Org Lett. 2011 Oct 7;13(19):5048-51
N1-(4-bis(pivaloyloxymethyl)phosphinylbuten-2-yl)thymine  0   *Phosphonic Acids Thymidine/*analogs & derivatives. J Med Chem 2011 Jan 13;54(1):222-32
diethylcyanophosphonate  0   *Phosphonic Acids. Chemistry 2011 Jun 14;17(25):6931-4
diethyl 2-((furan-2-ylmethyl)carbamoyl)ethylphosphonate  0   *Furans *Phosphonic Acids. Bioorg Med Chem 2011 Feb 1;19(3):1321-7
octadecyloxyethyl-cyclic-cidofovir  0   *Phosphonic Acids Cytosine/*analogs & derivatives. J Ocul Pharmacol Ther 2011 Apr;27(2):157-62
4-pentadecylbenzylphosphonic acid  0   *Phosphonic Acids. ChemMedChem. 2011 May 2;6(5):922-35
glycyl-prolyl-diphenylphosphonic acid  0   *Dipeptides *Phosphonic Acids Dipeptidyl Peptidase 4. Arch Dermatol Res 2010 Dec;302(10):725-31
3-phosphonoalanine  0   *Phosphonic Acids Alanine/*analogs & derivatives. Org Biomol Chem 2011 Jan 7;9(1):111-9
benzenetriyl-1,3,5-tris(methylphosphonic acid)  0   *Benzene Derivatives *Phosphonic Acids. Dalton Trans. 2010 Dec 7;39(45):11008-18
biphenyldiyl-2,2'-bis(methylphosphonic acid)  0   *Biphenyl Compounds *Phosphonic Acids. Dalton Trans. 2010 Dec 7;39(45):11008-18
diethyl (6-amino-9H-purin-9-yl) methylphosphonate  0   *Phosphonic Acids *Purines. Free Radic Res. 2010 Aug;44(8):881-90
(benzoxazol-2-ylmethyl)phosphonic acid  0   *Benzoxazoles *Phosphonic Acids. Inorg Chem. 2010 Oct 18;49(20):9369-79
(5-(2-amino-5-(2-methylpropyl)-4-thiazolyl)-2-furanyl)phosphonic acid  0   *Phosphonic Acids *Thiazoles Fructose-Bisphosphatase/antagonists & inhibitors. Proc Natl Acad Sci U S A 2005 May 31;102(22):7970-5
2-ethylhexyl phosphonic acid mono-2-ethylhexyl ester  0   *Phosphonic Acids. Chemosphere. 2010 Jun;80(4):433-7
octadecyloxyethyl 9-(2-(phosphonomethoxy)ethyl)guanine  0   *Phosphonic Acids Guanine/*analogs & derivatives. Chemotherapy 2010;56(1):54-9
acycloguanosine H-phosphonate  0   *Phosphonic Acids Acyclovir/*analogs & derivatives. Vopr Virusol. 2010 Jan-Feb;55(1):31-4
2-hydroxy-3-imidazo(1,2-a)pyridin-3-yl-2-phosphonopropionic acid  0   *Lactates *Phosphonic Acids. J Med Chem 2010 May 13;53(9):2454-64
hexakis(p-phosphonatophenyl)benzene  0   *Benzene Derivatives *Phosphonic Acids. Angew Chem Int Ed Engl. 2009;48(52):9951-3
poly((mu2-aqua(mu3-1-hydroxy-2-(1H,3H-imidazol-3-ium-1-yl)ethylidenediphosphonato)potassium(I))monohydrate)  0   *Imidazoles *Phosphonic Acids. Acta Crystallogr C. 2010 Jan;66(Pt 1):m13-6
ethyl phosphonate  0   *Phosphonic Acids. Acta Crystallogr Sect F Struct Biol Cryst Commun 2009 Sep 1;65(Pt 9):862-5
((5-methyl-2-pyridinio)aminomethylene)diphosphonate dianion  0   *Phosphonic Acids *Pyridines. Acta Crystallogr C. 2009 Jun;65(Pt 6):o261-6
1-(4-aminobutanoyl)-4-(1,3-bis(dihydroxyphosphoryloxy)propan-2-yloxy)-7-nitroindoline  0   *Indoles *Phosphonic Acids Receptors, GABA-A/antagonists & inhibitors. J Neurosci Methods 2009 Jul 30;181(2):159-69
170Tm-ethylenediamine-tetramethylenephosphonic acid  0   *Organometallic Compounds *Phosphonic Acids Thulium. Nucl Med Biol 2009 Jul;36(5):561-8
4-methylphosphonophenylisothiocyanate  0   *Phosphonic Acids *Isothiocyanates. J Am Soc Mass Spectrom 2009 Mar;20(3):377-84
FTY720-(E)-vinylphosphonate  0   *Vinyl Compounds Sphingosine/*analogs & derivatives Phosphonic Acids. J Org Chem. 2009 Apr 17;74(8):3192-5
hydroxymethylphosphonate  0   *Phosphonic Acids. J Antibiot (Tokyo) 1984 Nov;37(11):1505-8
1-(3-fluoro-2-(phosphonomethoxy)propyl)thymine  0   *Phosphonic Acids Thymine/*analogs & derivatives Thymidine Phosphorylase/antagonists & inhibitors. Biochem Pharmacol 2005 May 15;69(10):1517-21
3-mercaptopropylphosphonic acid  0   *Phosphonic Acids *Sulfhydryl Compounds. Bioelectrochemistry. 2009 Apr;75(1):26-31
propylphosphonic acid anhydride  0   *Anhydrides *Phosphonic Acids. Adv Exp Med Biol 2009;611:193-4
3,5-dimethyl-4-(4'-hydroxy-3'-isopropylbenzyl)phenoxy methylphosphonic acid  0   *Phenols *Phosphonic Acids. Br J Pharmacol 2009 Feb;156(3):454-65
2-((3,5-dimethyl-4-(4'-hydroxy-3'-isopropylbenzyl)phenoxy)methyl)-4-(3-chlorophenyl)-2-oxido(1,3,2)dioxaphosphonane  0   *Phosphonic Acids. J Med Chem 2008 Nov 27;51(22):7075-93
n-octylphosphonic acid  0   *Phosphonic Acids. Langmuir 2008 Dec 2;24(23):13450-6
(4-(tetradecanoylamino)benzyl)phosphonic acid  0   *Anilides *Phosphonic Acids. J Pharmacol Exp Ther 2008 Dec;327(3):809-19
2-hydroxybutylphosphonic acid  0   *Phosphonic Acids. Bioorg Med Chem Lett. 2008 May 15;18(10):3056-9
2-hydroxyethylphosphonic acid  0   *Phosphonic Acids. Bioorg Med Chem Lett. 2008 May 15;18(10):3056-9
2-hydroxypropylphosphonic acid  0   *Phosphonic Acids. Bioorg Med Chem Lett. 2008 May 15;18(10):3056-9
octadecyloxyethyl 9-(3-hydroxy-2-(phosphonomethoxy)propyl)adenine  0   *Phosphonic Acids Adenine/*analogs & derivatives. Antimicrob Agents Chemother 2006 Aug;50(8):2857-9
(6,7-dihydro-5H-cyclopenta(c)pyridin-7-yl(hydroxy)methylene)bis(phosphonic acid)  0   *Phosphonic Acids *Pyridines. Bioorg Med Chem Lett. 2008 May 1;18(9):2878-82
((4-chlorophenyl)-(hydroxyamidophosphinoyl)-methyl) phosphonic acid  0   *Hydrocarbons, Chlorinated *Phosphonic Acids. Eur J Med Chem. 2008 Apr;43(4):885-92
((3-bromo-7-cyano-2-naphthyl)(difluoro)methyl)phosphonic acid  0   *Naphthalenes *Phosphonic Acids. Bioorg Med Chem Lett 2008 Jun 1;18(11):3200-5
2-aminocyclohexylcarbamoylphosphonic acid  0   *Phosphonic Acids Matrix Metalloproteinases/antagonists & inhibitors. J Med Chem 2008 Mar 13;51(5):1406-14
9-(5',5'-difluoro-5'-phosphonopentyl)-9-deazaguanine  0   *Phosphonic Acids Guanine/*analogs & derivatives. Nucleic Acids Symp Ser (Oxf) 2007;(51):431-2
N-(2-methyl-2-propyl)-N-(1-diethylphosphono-2,2-dimethylpropyl)-N-oxyl  0   *Phosphonic Acids. Chemphyschem 2008 Feb 1;9(2):272-81
ethane-1,1,2-trisphosphonic acid  0   *Phosphonic Acids Ethane/*analogs & derivatives. Acta Crystallogr C. 2008 Feb;64(Pt 2):o47-9
methyl 1-(bis(4-acetamidophenoxy)phosphoryl)-2-(4-guanidinophenyl)ethylcarbamate  0   *Guanidines *Phosphonic Acids Urokinase-Type Plasminogen Activator/antagonists & inhibitors. J Med Chem 2007 Dec 27;50(26):6638-46
methyl 1-(diphenoxyphosphoryl)-2-(4-guanidinophenyl)ethylcarbamate  0   *Guanidines *Phosphonic Acids Urokinase-Type Plasminogen Activator/antagonists & inhibitors. J Med Chem 2007 Dec 27;50(26):6638-46
2-fluoro-3-(3-pyridinyl)-2-phosphonopropionic acid  0   *Phosphonic Acids *Propionic Acids. J Med Chem 2007 Nov 29;50(24):5967-75
(5-(6-amino-purin-9-yl)-2,5-dihydrofuran-2-yloxymethyl)phosphonic acid  0   *Nucleosides *Phosphonic Acids. Bioorg Med Chem Lett 2007 Dec 15;17(24) (dup#1):6785-9
alpha-ethyl-N-(phosphonomethyl)glycine  0   *Phosphonic Acids Glycine/*analogs & derivatives. Amino Acids 2007 Nov;33(4):695-702
cidofovir hexadecyloxypropyl ester  0   *Phosphonic Acids Cytosine/*analogs & derivatives. Antimicrob Agents Chemother 2007 Nov;51(11):4118-24
methyl linolenoylfluorophosphonate  0   *Phosphonic Acids. J Lipid Res 2007 Nov;48(11):2365-76
hexadecyloxypropyl 9-(2-(phosphonomethoxy)propyl)adenine  0   *Phosphonic Acids Adenine/*analogs & derivatives. Antimicrob Agents Chemother 2007 Oct;51(10):3505-9
O-phenyl (triphenylphosphoniomethyl)phosphonate  0   *Phosphonic Acids. Acta Crystallogr C 2007 Sep;63(Pt 9):o504-6
(4-iodo-phenyl)phenyl phosphinic acid  0   *Phosphonic Acids. Langmuir 2007 Jul 17;23(15):8257-63
1-amino-2-phosphonomethylcyclopropanecarboxylic acid  0   *Amino Acids *Phosphonic Acids Cyclopropanes Receptors, Metabotropic Glutamate/agonists. J Med Chem 2007 Jul 26;50(15):3585-95
cyclohexane-1,2-diamine-N,N,N',N'-tetrakis(methylenephosphonic acid)  0   *Cyclohexylamines *Phosphonic Acids. Dalton Trans 2006 Sep 28;(36):4384-94
more...

To share this definition, click "text" (Facebook, Twitter) or "link" (blog, mail) then paste text link
Ads by Google

Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
This website is accredited by Health On the Net Foundation. Click to verify. We comply with the HONcode standard for trustworthy health information: verify here.
About Reference.MD Privacy