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Adenine

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Definition: A purine base and a fundamental unit of ADENINE NUCLEOTIDES.  /biosyn/physiol permitted   
Examples 2-Aminopurine; Cytokinins 		Other names Vitamin B 4; B 4, Vitamin; 4, Vitamin B
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
MPI-0479605  0   *Morpholines Adenine/*analogs & derivatives. Mol Cancer Ther. 2011 Dec;10(12):2267-75.
PF 5168899  0   *Pyrazines Adenine/*analogs & derivatives. Anal Biochem 2011 Jul 15;414(2):179-86
9-benzyl-2-butoxy-8-hydroxyadenine  0   Adenine/*analogs & derivatives Ligands. J Immunol 2011 Apr 15;186(8):4707-15
2-chloro-N-(2-(5-(dimethylamino)naphthalene-1-sulfonamido)ethyl)-4-(2-(1-hydroxy-3-methylbutan-2-ylamino)-9-isopropyl-9H-purin-6-ylamino)benzamide  0   *Dansyl Compounds Adenine/*analogs & derivatives. Cancer Biol Ther 2010 Aug;10(4):320-5
methylthio-DADMe-immucillin-A  0   *Pyrrolidines Adenine/*analogs & derivatives. J Biol Chem 2011 Feb 11;286(6):4902-11
longdaysin  0   Adenine/*analogs & derivatives Circadian Rhythm. PLoS Biol 2010;8(12):e1000559
2-(9H-purin-6-ylamino)-4-(methylamino)butanoic acid  0   Adenine/*analogs & derivatives Methionine/*analogs & derivatives. J Biomater Sci Polym Ed 2010;21(12):1603-17
(4-(5-furan-2-yl-3-methyl-1H-pyrazol-4-yl)-butyl)methyl-(7H-purin-6-yl)amine  0   *Pyrazoles Adenine/*analogs & derivatives HSP90 Heat-Shock Proteins/antagonists & inhibitors. ChemMedChem 2010 Oct 4;5(10):1697-700
BG-Cy3-Cy5  0   *Carbocyanines Adenine/*analogs & derivatives. Chembiochem 2010 Jul 5;11(10):1361-3
3-(benzyloxycarbonylleucylamino)-N-(3-(6-amino-9H-purin-9-yl)propyl)-2-oxopentanamide  0   *Dipeptides Adenine/*analogs & derivatives Calpain/antagonists & inhibitors. J Med Chem 2010 Sep 9;53(17):6326-36
9-propargyladenine  0   Adenine/*analogs & derivatives. Chem Commun (Camb). 2010 May 21;46(19):3265-7
AP 24163  0   *Benzamides Adenine/*analogs & derivatives. Chem Biol Drug Dev 2010 Feb;75(2):223-7
(9-methyl-adenine)(2)-(1-methyl-thymine)(2)  0   Adenine/*analogs & derivatives. J Am Chem Soc. 2009 Oct 28;131(42):15232-45
adeninediium hemioxalate chloride  0   Adenine/*analogs & derivatives. Acta Crystallogr C. 2009 May;65(Pt 5):o202-6
adenine thiamine diphosphate  0   Adenine/*analogs & derivatives Thiamine Pyrophosphate/*analogs & derivatives. FEBS J 2009 Jun;276(12):3256-68
aphrocallistin  0   Adenine/*analogs & derivatives Tyramine/*analogs & derivatives. J Nat Prod 2009 Jun;72(6):1178-83
6-(2-hydroxy-2-methylbenzylamino)purine  0   Adenine/*analogs & derivatives. FEBS J 2009 Jan;276(1):244-53
purfalcamine  0   *Cyclohexylamines Adenine/*analogs & derivatives. Nat Chem Biol 2008 Jun;4(6):347-56
octadecyloxyethyl 9-(3-hydroxy-2-(phosphonomethoxy)propyl)adenine  0   *Phosphonic Acids Adenine/*analogs & derivatives. Antimicrob Agents Chemother 2006 Aug;50(8):2857-9
2,2-dimethylpropionic acid 3-(2-chloro-6-methylaminopurin-9-yl)-2-(2,2-dimethylpropionyloxymethyl)propyl ester  0   *Valerates Adenine/*analogs & derivatives. Br J Pharmacol 2007 May;151(1):73-81
3-deaza-3-methyladenine  0   Adenine/*analogs & derivatives. Nucleic Acids Res 2008 Apr;36(7):2152-62
6N-acetyl-8-aza-7-deazaadenine  0   Adenine/*analogs & derivatives. Nucleic Acids Res 2008 Apr;36(6):1952-64
hexadecyloxypropyl 9-(2-(phosphonomethoxy)propyl)adenine  0   *Phosphonic Acids Adenine/*analogs & derivatives. Antimicrob Agents Chemother 2007 Oct;51(10):3505-9
6-chloro-9-(4-methoxy-3,5-dimethylpyridin-2-ylmethyl)-9H-purin-2-ylamine  0   *Pyridines Adenine/*analogs & derivatives HSP90 Heat-Shock Proteins/antagonists & inhibitors. J Med Chem 2007 Jun 14;50(12):2767-78
6-chloro-9-(5-methoxy-4,6-dimethylpyridin-3-ylmethyl)-9H-purin-2-ylamine  0   *Pyridines Adenine/*analogs & derivatives HSP90 Heat-Shock Proteins/antagonists & inhibitors. J Med Chem 2007 Jun 14;50(12):2767-78
2-amino-6-chloro-9-(4-iodo-3,5-dimethylpyridin-2-ylmethyl)purine  0   *Pyridines Adenine/*analogs & derivatives HSP90 Heat-Shock Proteins/antagonists & inhibitors. J Med Chem 2007 Jun 14;50(12):2767-78
2-amino-6-hydroxy-8-mercaptopurine  0   Adenine/*analogs & derivatives. BMC Biochem 2007;8:8
GS-9131  0   Adenine/*analogs & derivatives. Antimicrob Agents Chemother 2007 Feb;51(2):543-50
N6-(2-hydroxy-3-buten-1-yl)adenine  0   Adenine/*analogs & derivatives. Chem Biol Interact 2007 Mar 20;166(1-3):104-11
9-(3-bromo-2-(2,3-dibromo-4,5-dihydroxybenzyl)-4,5-dihydroxybenzyl)adenine  0   Adenine/*analogs & derivatives. J Nat Prod 2007 Mar;70(3):337-41
N3-(2-carbamoyl-2-hydroxyethyl)adenine  0   Adenine/*analogs & derivatives. Toxicol Sci 2007 Feb;95(2):383-90
efavirenz, emtricitabine, tenofovir disoproxil fumarate drug combination  0   *Oxazines *Phosphonic Acids Adenine/*analogs & derivatives Deoxycytidine/*analogs & derivatives Drug Combinations.
Pharma Action Reverse Transcriptase Inhibitors 		Med Lett Drugs Ther 2006 Sep 25;48(1244):78-9EFAVIRENZ/LAMIVUDINE/TENOFOVIR DISOPROXIL FUMARATE; ATRIPLA; EFAVIRENZ; EMTRICITABINE; TENOFOVIR DISOPROXIL FUMARATE
9-(1,3-anhydro-beta-D-psicofuranosyl)adenine  0   *Furans Adenine/*analogs & derivatives. Acta Crystallogr C. 2006 Nov;62(Pt 11):o659-60
4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin A  0   *Pyrrolidines Adenine/*analogs & derivatives Purine-Nucleoside Phosphorylase/antagonists & inhibitors. Biochemistry 2007 Jan 23;46(3):659-68
immucillin A  0   *Pyrrolidines Adenine/*analogs & derivatives Purine-Nucleoside Phosphorylase/antagonists & inhibitors. Biochemistry 2007 Jan 23;46(3):659-68
9-(2-(boranophosphonomethoxy)propyl)adenine  0   *Boron Compounds Adenine/*analogs & derivatives. J Med Chem 2006 Dec 28;49(26):7799-806
9-(2-(boranophosphonomethoxy)ethyl)adenine  0   *Boron Compounds Adenine/*analogs & derivatives. J Med Chem 2006 Dec 28;49(26):7799-806
N8-(2'-O-methylribofuranosyl)-8-aza-7-deazaadenine monohydrate  0   *Monosaccharides Adenine/*analogs & derivatives. Acta Crystallogr C. 2006 Feb;62(Pt 2):o79-81
1,N6-propanoadenine  0   Adenine/*analogs & derivatives. Am J Pathol. 2006 Oct;169(4):1328-42
ethyl adenine-9-acetate  0   *Acetates Adenine/*analogs & derivatives. Org Lett. 2005 Sep 15;7(19):4079-81
9-(3-deoxy-beta-D-glycero-pent-3-enofuranosyl)adenine  0   *Furans Adenine/*analogs & derivatives. J Org Chem. 2006 Feb 3;71(3):1099-103
AP 23451  0   *Phosphonic Acids Adenine/*analogs & derivatives src-Family Kinases/antagonists & inhibitors. Chem Biol Drug Des 2006 Jan;67(1):46-57
2-butylamino-8-hydroxy-9-(6-methylpyridine-3-ylmethyl)adenine  0   *Pyridines Adenine/*analogs & derivatives. J Med Chem 2006 Mar 23;49(6):2088-95
7-(hydroxymethyl)-1,N(6)-ethenoadenine  0   Adenine/*analogs & derivatives. DNA Repair (Amst) 2006 Jan 5;5(1):23-31
methyl 4-(adenin-9-yl)-2-hydroxybutanoate  0   *Butyric Acids Adenine/*analogs & derivatives. J Pharmacol Exp Ther. 2006 Mar;316(3):1229-37
erythro-(3-nonyl-p-aminobenzyl-adenine)  0   *Benzyl Compounds Adenine/*analogs & derivatives. J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Feb 2;831(1-2):334
SM360320  0   Adenine/*analogs & derivatives.
9-(2-(2,2-dimethylpropylamino)ethyl)-8-(2-iodo-5-methoxyphenylsulfanyl)-9H-purin-6-ylamine  0   Adenine/*analogs & derivatives HSP90 Heat-Shock Proteins/antagonists & inhibitors. J Med Chem 2006 Jan 26;49(2):817-28
8-(2-iodo-5-methoxyphenylsulfanyl)-9-(3-isopropylaminiopropyl)-9H-purin-6-ylamine  0   Adenine/*analogs & derivatives HSP90 Heat-Shock Proteins/antagonists & inhibitors. J Med Chem 2006 Jan 26;49(2):817-28
9-(3-sec-butylaminopropyl)-8-(2-iodo-5-methoxyphenylsulfanyl)-9H-purin-6-ylamine  0   Adenine/*analogs & derivatives HSP90 Heat-Shock Proteins/antagonists & inhibitors. J Med Chem 2006 Jan 26;49(2):817-28
9-beta-D-erythrofuranosyladenine  0   *Furans Adenine/*analogs & derivatives. Blood. 2006 Feb 1;107(3):898-903
8-chloroadenine  0   Adenine/*analogs & derivatives. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Nov 15;827(1):26-31
2-n-butyl-9-methyl-8-(1,2,3)triazol-2-yl-9H-purin-6-ylamine  0   *Triazoles Adenine/*analogs & derivatives Receptor, Adenosine A2A/antagonists & inhibitors. J Med Chem 2005 Nov 3;48(22):6887-96
bis(hydroxymethyl)cyclopentenyl adenine  0   *Cyclopentanes Adenine/*analogs & derivatives. J Org Chem. 2005 May 13;70(10):4199-202
aminopurvalanol A  0   Adenine/*analogs & derivatives. Mol Biochem Parasitol 2005 May;141(1):15-27
8-ethoxy- 9-ethyladenine  0   Adenine/*analogs & derivatives. Eur J Pharmacol. 2005 Apr 11;512(2-3):157-64
8-furyl-9-ethyladenine  0   Adenine/*analogs & derivatives. Eur J Pharmacol. 2005 Apr 11;512(2-3):157-64
8-bromo-9-ethyladenine  0   Adenine/*analogs & derivatives. Eur J Pharmacol. 2005 Apr 11;512(2-3):157-64
9-(2',3'-dideoxy-2',3'-didehydro-2'-fluoro-6'-hydroxymethylcyclopent-2-enyl)adenine  0   *Cyclopentanes Adenine/*analogs & derivatives. J Med Chem 2005 Jun 2;48(11):3736-48
9-(pent-4-ynyl)-8-(6-bromobenzo(1,3)dioxol-5-ylsulfanyl)adenine  0   Adenine/*analogs & derivatives HSP90 Heat-Shock Proteins/antagonists & inhibitors. J Med Chem 2005 Apr 21;48(8):2892-905
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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