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Pyrazines

More information in Books or onNLM PubMed
Definition:   do not confuse with PYRIDAZINES   
Examples Amiloride; Pyrazinamide
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
7-ethyl-6,8-bis(methylthio)pyrrolo(1,2-a)pyrazine  0   *Pyrazines *Pyrroles. Carcinogenesis. 2012 Mar;33(3):661-9.
S35972  0   *Pyrazines *Pyridines *Pyrroles Anticoagulants. J Thromb Haemost. 2011 Jul;9(7):1375-82
6,8-diphenylimidazo(1,2-alpha)pyrazine  0   *Imidazoles *Pyrazines. Spectrochim Acta A Mol Biomol Spectrosc. 2011 Sep;79(5):1220-5
SCH 1473759  0   *Imidazoles *Pyrazines. Cancer Chemother Pharmacol 2011 Oct;68(4):923-33
8a-methyl-1,3-dioxo-2-(2-phenylcyclopropyl)-N-(1-phenyl-1H-pyrazol-5-yl)hexahydroimidazo(1,5-a)pyrazine-7(1H)-carboxamide  0   *Imidazoles *Pyrazines. Bioorg Med Chem Lett 2011 Aug 1;21(15):4422-8
3-(pyrazin-2-ylcarbonyl)dithiocarbazic acid  0   *Hydrazines *Pyrazines. Acta Crystallogr C. 2011 Jul;67(Pt 7):o235-40
cuprineoaspergillin  0   *Organometallic Compounds *Pyrazines Copper. Nat Prod Commun. 2011 Aug;6(8):1137-40
ferrineoaspergillin  0   *Ferric Compounds *Pyrazines. Nat Prod Commun. 2011 Aug;6(8):1137-40
JBIR-57  0   *Oligopeptides *Pyrazines. J Nat Prod. 2011 Jul 22;74(7):1630-5
JBIR-56  0   *Oligopeptides *Pyrazines. J Nat Prod. 2011 Jul 22;74(7):1630-5
N-(1-ethylpropyl)-(3-methoxy-5-(2-methoxy-4-trifluoromethoxyphenyl)-6-methyl-pyrazin-2-yl)amine  0   *Pyrazines. J Med Chem 2011 Jun 23;54(12):4187-206
PF 5168899  0   *Pyrazines Adenine/*analogs & derivatives. Anal Biochem 2011 Jul 15;414(2):179-86
2-(((1,1-dimethylethyl)oxidoimino)methyl)-3,5,6-trimethylpyrazine  0   *Pyrazines. Eur J Drug Metab Pharmacokinet. 2011 Jun;36(2):95-101
3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide  0   *Pyrazines *Sulfones. Nat Chem Biol 2011;7(7):428-30
DLJ14 compound  0   *Pyrazines. Toxicol In Vitro. 2011 Jun;25(4):937-43
2-(4-(3-quinolin-6-ylmethyl-3H-(1,2,3)triazolo(4,5-b)pyrazin-5-yl)pyrazol-1-yl)ethanol  0   *Pyrazines *Triazoles. Drug Metab Dispos 2011 Mar;39(3):383-93
imidazo(1,2-a)pyrazine  0   *Imidazoles *Pyrazines. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6739-43
hyrtioseragamine B  0   *Furans *Pyrazines Alkaloids. Org Lett. 2011 Feb 18;13(4):628-31
hyrtioseragamine A  0   *Furans *Pyrazines Alkaloids. Org Lett. 2011 Feb 18;13(4):628-31
3-bromo-N-(diaminomethylidene)-4-(((3,5,6-trimethylpyrazin-2-yl)methyl)amino)benzamide hydrochloride  0   *Benzamides *Pyrazines. Chem Biodivers. 2010 Nov;7(11):2727-36
N-(diaminomethylidene)-3-nitro-4-(((3,5,6-trimethylpyrazin-2-yl)methyl)amino)benzamide hydrochloride  0   *Benzamides *Pyrazines. Chem Biodivers. 2010 Nov;7(11):2727-36
3-bromo-N-(diaminomethylidene)-4-((3,5,6-trimethylpyrazin-2-yl)methoxy)benzamide hydrochloride  0   *Benzamides *Pyrazines. Chem Biodivers. 2010 Nov;7(11):2727-36
leuvalin  0   *Pyrazines. Chem Biol 2010 Sep 24;17(9):925-30
tyrvalin  0   *Pyrazines. Chem Biol 2010 Sep 24;17(9):925-30
tetramethylpyrazine diphenylmethyl piperazidine  0   *Pyrazines Antioxidants. Pharmazie. 2010 Oct;65(10):755-9
4-((2-cyclobutyl-1H-imidazo(4,5-b)pyrazin-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one  0   *Pyrazines *Fluoroquinolones Nitric Oxide Synthase Type II/antagonists & inhibitors Nitric Oxide Synthase Type I/antagonists & inhibitors. J Med Chem 2009 May 14;52(9):3047-62
pyrazine-2-carboxylate  0   *Pyrazines. Biodegradation. 2010 Sep;21(5):801-13
3,5-dimethyl-2-methoxypyrazine  0   *Pyrazines. Bull Environ Contam Toxicol. 2010 Aug;85(2):160-4
1,8-naphthyridine-pyrido(2,3-b)pyrazine  0   *Naphthyridines *Pyrazines. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4359-63
AKN 032  0   *Pyrazines. Biochem Pharmacol 2010 Nov 15;80(10):1507-16
CXC 195  0   *Piperazines *Pyrazines. Bioorg Med Chem Lett 2010 Feb 1;20(3):432-8
pyrazine-2-carboxylic acid hydrazide  0   *Hydrazines *Pyrazines. Eur J Med Chem. 2010 Aug;45(8):3384-8
2,3,5,6-tetrakis(2-pyridyl)pyrazine  0   *Pyrazines. Inorg Chem. 2010 Jun 21;49(12):5353-5
3-(8-amino-1-(2-phenylquinolin-7-yl)imidazo(1,5-a)pyrazin-3-yl)-1-methylcyclobutanol  0   *Imidazoles *Pyrazines. Clin Cancer Res 2010 Jun 15;16(12):3193-204
aureusimine A  0   *Pyrazines. Science. 2010 Jul 16;329(5989):294-6
NBRI16716A  0   *Pyrazines. J Antibiot (Tokyo). 2010 Jun;63(6):319-23
9-oxo-9H-indeno(1,2-b)pyrazine-2,3-dicarbonitrile  0   *Indenes *Pyrazines. ChemMedChem 2010 Apr 6;5(4):552-8
tatarinine A  0   *Pyrazines. Asian Nat Prod Res. 2010 Jun;12(6):438-42
((3)H)-1-((N-propylpiperidin-4-yl)methoxy)-pyrrolo(1,2-a)thieno(2,3-e)pyrazine  0   *Piperidines *Pyrazines. Eur J Med Chem. 2010 Mar;45(3):1263-5
1,2,3,4-tetrahydropyrrolo(1,2-a)pyrazine  0   *Pyrazines *Pyrroles. Eksp Klin Farmakol. 2010 Mar;73(3):11-4
3-(4-(2-hydroxyethyl)piperazin-1-yl)-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido(3,4-b)pyrazin-2(1H)-one  0   *Pyrazines *Pyridines Cyclic Nucleotide Phosphodiesterases, Type 5/antagonists & inhibitors. J Med Chem 2010 Mar 25;53(6):2656-60
1-(N-(2-(Amidinoaminooxy)ethyl)amino)carbonylmethyl-6-methyl-3-(2,2-difluoro-2-phenylethylamino)pyrazinone  0   *Guanidines *Pyrazines Thrombin. J Med Chem 2010 Feb 25;53(4):1843-56
SAR 020106  0   *Isoquinolines *Pyrazines. Mol Cancer Ther 2010 Jan;9(1):89-100
BMS 665053  0   *Pyrazines. Drug Metab Dispos 2010 Jan;38(1):5-15
2,5-dimethyl-3-(3-methylbutyl)pyrazine  0   *Pyrazines. J Chem Ecol 2009 Aug;35(8):861-70
2,5-dimethyl-3-(2-methylbutyl)pyrazine  0   *Pyrazines. J Chem Ecol 2009 Aug;35(8):861-70
3-isobutyl-2,5-dimethylpyrazine  0   *Pyrazines. J Chem Ecol 2009 Aug;35(8):861-70
5-tert-butyl-6-chloro-N-(3-iodo-4-methyl-phenyl)pyrazine-2-carboxamide  0   *Pyrazines. Molecules. 2009;14(10):4180-9
N-(3-iodo-4-methylphenyl)pyrazine-2-carboxamide  0   *Pyrazines. Molecules. 2009;14(10):4180-9
HBX 41,108  0   *Indenes *Pyrazines. Mol Cancer Ther 2009 Aug;8(8):2286-95
4-(1-cyclopropyl-2-methoxyethyl)-6-(6-(difluoromethoxy)-2,5-dimethylpyridin-3-ylamino)-5-oxo-4,5-dihydropyrazine-2-carbonitrile  0   *Pyrazines *Pyridines Receptors, Corticotropin-Releasing Hormone/antagonists & inhibitors. J Med Chem 2009 Dec 10;52(23):7653-68
7,7'-bis(thiophen-2-yl)-5,5'-bisthieno(3,4-b)pyrazine  0   *Pyrazines *Thiophenes. J Phys Chem A. 2009 Sep 24;113(38):10343-50
7-n-butyl-6-(4'-hydroxyphenyl)-5H-pyrrolo(2,3b)pyrazine  0   *Pyrazines *Pyrroles. Bioorg Med Chem. 2009 Aug 1;17(15):5572-82
tetracyanopyrazinide  0   *Nitriles *Pyrazines. J Am Chem Soc. 2009 Jul 1;131(25):9070-5
2-chloropyrazine  0   *Pyrazines. J Org Chem. 2009 Apr 17;74(8):3221-4
coelenteramide  0   *Pyrazines *Benzeneacetamides. Biochem Biophys Res Commun 2009 Sep 4;386(4):617-22
3,6-dihydro-2,5-dimethylpyrazine  0   *Pyrazines. Int J Pharm 2009 Jun 5;374(1-2):601-9
N,N'-diethylpyrazinediium bis(tetrafluoroborate)  0   *Pyrazines. Acta Crystallogr C. 2009 May;65(Pt 5):o226-8
N,N'-dimethylpyrazinediium bis(tetrafluoroborate)  0   *Pyrazines. Acta Crystallogr C. 2009 May;65(Pt 5):o226-8
3,4-dihydropyrazino(1,2-b)indazole  0   *Indazoles *Pyrazines. J Comb Chem. 2009 May-Jun;11(3):341-4
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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