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Nitriles

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Definition: Organic compounds containing the -CN radical. The concept is distinguished from CYANIDES, which denotes inorganic salts of HYDROGEN CYANIDE.  organic cpds having -CN radical: differentiate from CYANIDES which are inorganic with -CN   
See Also Cyanides
Examples Acetonitriles; Acrylonitrile; Aminopropionitrile; Amygdalin; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cyanoacrylates; o-Chlorobenzylidenemalonitrile; Citalopram; Fadrozole; Pregnenolone Carbonitrile; Technetium Tc 99m Sestamibi; Tyrphostins
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
4'-methylbiphenyl-2-carbonitrile  0   *Biphenyl Compounds *Nitriles. Spectrochim Acta A Mol Biomol Spectrosc. 2012 Feb 15;87():273-85
3,4-dihydro-2-(4-chlorophenyl)-6-(4-methoxyphenyl)-4-oxo-pyrimidine-5-carbonitrile  0   *Nitriles *Pyrimidines. Molecules. 2012;17(1) (dup#13):809-19
3,4-dihydro-2-phenyl-6-para-fluorophenyl-4-oxo-pyrimidine-5-carbonitrile  0   *Nitriles *Pyrimidines. Molecules. 2012;17(1) (dup#13):809-19
3-cyanopropene  0   *Nitriles Propane/*analogs & derivatives. J Phys Chem A. 2011 Nov 24;115(46):13467-73
tri-p-quinodimethane  0   *Nitriles Fleroxacin/*analogs & derivatives. J Am Chem Soc. 2011 Oct 19;133(41):16342-5
1-((2-adamantyl)amino)acetyl-2-cyano-(S)-pyrrolidine, monohydrochloride  0   *Nitriles *Pyrrolidines Adamantane/*analogs & derivatives Hypoglycemic Agents Dipeptidyl-Peptidase IV Inhibitors. J Pharmacol Exp Ther. 2012 Jan;340(1):64-72
2-(3-cyano-5-(3,4-dichlorophenyl)-4,5-dimethylfuran-2(5H)-ylidene)malononitrile  0   *Furans *Nitriles. J Med Chem. 2011 Oct 27;54(20):7385-96.
4-methylphthalonitrile  0   *Nitriles. J Mol Model. 2011 Jan;17(1):49-58
N-cyano-N-phenyl-para-toluenesulfonamide  0   *Nitriles *Sulfonamides Toluene/*analogs & derivatives. Org Lett. 2011 Oct 21;13(20):5608-11
imidazole-4,5-dicarbonitrile  0   *Imidazoles *Nitriles. J Fluoresc. 2011 Jul;21(4):1779-87
methyl-5-amino-4-cyano-3-(methylthio)-1H-pyrazole-1-carbodithioate  0   *Nitriles *Pyrazoles *Thiocarbamates. Spectrochim Acta A Mol Biomol Spectrosc. 2011 Sep;79(5):1722-30
1,3-bis(4,6-dimethyl-1H-nicotinonitrile-1-yl)1,3-dioxy propane  0   *Nicotinic Acids *Nitriles. Spectrochim Acta A Mol Biomol Spectrosc. 2011 Sep;79(5):1267-75
2-(2-(4-(bis(2-(2-aminophenylsulfanyl) ethyl)amino)phenyl)vinyl)-5-methylterephthalonitrile  0   *Nitriles *Vinyl Compounds. Anal Chim Acta. 2011 Aug 12;699(2):198-205
P-N,N-dimethylaminobenzylidenemalononitrile  0   *Benzylidene Compounds *Nitriles. Spectrochim Acta A Mol Biomol Spectrosc. 2011 Aug;79(3):443-50
2-((1H-pyrrol-2-ylmethylidene)amino)benzonitrile  0   *Nitriles *Pyrroles. Acta Crystallogr C. 2011 Aug;67(Pt 8):o315-8
4-cyano-3-nitrobenzoic acid  0   *Nitriles *Nitrobenzoates. J Org Chem. 2011 Apr 1;76(7):2350-4
butyl 2-cyano-3, 11-dioxours-1,12-dien-24-oate  0   *Nitriles *Polycyclic Compounds. Eur J Pharmacol. 2011 Jun 25;660(2-3):241-8
2-chloro-6-((3-((1,1-dimethyl-2-(4-(methyloxy)phenyl)ethyl)amino)-2-hydroxypropyl)oxy)benzonitrile  0   *Nitriles. AAPS J 2011 Jun;13(2):265-73
2,5-di-(2-(4-hydroxy-phenyl)ethylene)-terephthalonitril  0   *Nitriles. Spectrochim Acta A Mol Biomol Spectrosc. 2011 Jun;79(1):97-103
N,N-dimethylaminonapthyl-(acrylo)-nitrile  0   *Nitriles 1-Naphthylamine/*analogs & derivatives. Spectrochim Acta A Mol Biomol Spectrosc 2011 May;78(5):1525-34
1,8-diisocyano-p-menthane  0   *Nitriles. J Phys Chem A. 2011 Apr 14;115(14):2920-6
geranyllinaloisocyanide  0   *Diterpenes *Nitriles. Org Lett. 2011 May 20;13(10):2520-3
actisonitrile  0   *Lipids *Nitriles. Org Lett. 2011 Apr 15;13(8):1897-9
4-cyano-N,N,5-trimethyl-7-((3S)-3-methyl-3-(methylamino) pyrrolidin-1-yl)-6-phenyl-1,3-benzoxazole-2-carboxamide  0   *Benzoxazoles *Nitriles. Chem Pharm Bull (Tokyo). 2011;59(3):341-52
3-bromoisothiazole-4-carbonitrile  0   *Nitriles *Thiazoles. Org Lett. 2011 Mar 18;13(6):1510-3
2-(diphenylphosphino)benzonitrile  0   *Nitriles *Phosphines. Org Lett. 2011 Mar 4;13(5):1001-3
4-methyl-2-cyanobiphenyl  0   *Biphenyl Compounds *Nitriles. Spectrochim Acta A Mol Biomol Spectrosc. 2011 Feb;78(2):590-600
2-chlorobenzonitrile  0   *Nitriles. Spectrochim Acta A Mol Biomol Spectrosc. 2011 Feb;78(2):582-9
tetrakis(4-isocyanatophenyl)methane  0   *Benzyl Compounds *Nitriles. Angew Chem Int Ed Engl. 2010 Dec 3;49(49):9504-8
2,7-di-tert-butyl-4,5,9,10-tetracyanopyrene  0   *Nitriles *Pyrenes. Chem Commun (Camb). 2011 Jan 7;47(1):316-8
3-methylthio-5-phenyl-4-isothiazolecarbonitrile  0   *Nitriles *Thiazoles Poliovirus. Antiviral Res. 2010 Dec;88(3):325-8
2-((2E)-3-(4-tert-butylphenyl)-2-methylprop-2-enylidene)malononitrile  0   *Nitriles. J Mass Spectrom. 2010 Oct;45(10):1195-202
1,4,5,8,9,12-hexaazatriphenylene-hexacarbonitrile  0   *Nitriles *Quinoxalines. Angew Chem Int Ed Engl 2010 Sep 24;49(40):7202-7
alpha-phenylethyl isocyanide  0   *Nitriles. Phys Chem Chem Phys. 2010 Oct 7;12(37):11624-9
1,4-diisocyanobenzene  0   *Benzene Derivatives *Nitriles. Phys Chem Chem Phys. 2010 Oct 7;12(37):11624-9
CCl3CN compound  0   *Hydrocarbons, Chlorinated *Nitriles. Org Lett. 2010 Sep 17;12(18):4195-7
cyanoethenethiol  0   *Nitriles *Sulfhydryl Compounds. J Phys Chem A. 2010 Sep 9;114(35):9583-8
2-phenyl-9H-purine-6-carbonitrile  0   *Nitriles *Purines. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4447-50
6-phenyl-1H-imidazo(4,5-c)pyridine-4-carbonitrile  0   *Nitriles *Pyridines. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4350-4
3-phenoxyphthalonitrile  0   *Nitriles. Spectrochim Acta A Mol Biomol Spectrosc. 2010 Sep 15;77(1):45-50
CH4933468  0   *Nitriles *Sulfonamides. Bioorg Med Chem. 2010 May 1;18(9):3159-68
3-aminothiazolo(3,2-a)benzimidazole-2-carbonitrile  0   *Benzimidazoles *Nitriles. Eur J Med Chem. 2010 Jun;45(6):2689-94
N-cyanobenzimidazole  0   *Benzimidazoles *Nitriles. Chemistry. 2010 Apr 26;16(16):4725-8
3,3-dimethoxypropanenitrile  0   *Nitriles. J Org Chem. 2010 Jan 15;75(2):487-90
2-cyano-2-isonitrosoacetamide  0   *Acetamides *Nitriles. Dalton Trans. 2010 Jan 21;39(3):749-64
enaminonitrile  0   *Heterocyclic Compounds, 2-Ring *Nitriles. Eur J Med Chem. 2009 Dec;44(12):4813-8
4-(3-cyanophenyl)butylene  0   *Butanes *Nitriles. J Am Chem Soc. 2010 Feb 10;132(5):1450-1
(S)-2-methylbutyronitrile  0   *Nitriles. Chemistry. 2009 Nov 16;15(45):12371-80
2-amino-4,6-diphenylpyridine-3-carbonitrile  0   *Nitriles *Pyridines. Mol Divers. 2009 Nov;13(4):545-9
o-tolunitrile  0   *Nitriles. Spectrochim Acta A Mol Biomol Spectrosc. 2009 Dec;74(5):1280-7
dicyanosulfide  0   *Nitriles *Sulfides. Chem Res Toxicol 2009 Sep;22(9):1622-8
ceratinamine  0   *Bromobenzenes *Formamides *Nitriles. Org Biomol Chem. 2009 Oct 7;7(19):3991-9
2,3,4-trifluorobenzonitrile  0   *Nitriles. Spectrochim Acta A Mol Biomol Spectrosc 2009 Sep 15;74(1):200-4
1-cyano-2,3-epithiopropane  0   *Nitriles *Sulfhydryl Compounds Propane/*analogs & derivatives. Carcinogenesis. 2009 Oct;30(10):1754-62
3-(5-(3,5-difluorophenyl)-3-((((1S,3R)-3-fluorocyclopentyl)amino)methyl)-4-methyl-1H-pyrazol-1-yl)propanenitrile  0   *Nitriles *Pyrazoles. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4729-32
3,5-dichlorobenzonitrile  0   *Nitriles. J Plant Res 2008 Mar;121(2):227-33
tetracyanopyrazinide  0   *Nitriles *Pyrazines. J Am Chem Soc. 2009 Jul 1;131(25):9070-5
4,4'-methanol-bisbenzonitrile  0   *Nitriles. Cancer Chemother Pharmacol. 2009 Oct;64(5):867-75
cyhalofop-acid  0   *Nitriles *Propionic Acids. J Agric Food Chem 2009 Jun 24;57(12):5461-7
5-phenyl-3-pyridinecarbonitrile-(4-methylindol-5-ylamino)-5-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl  0   *Indoles *Nitriles. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3623-6
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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