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ψ
ψ
Nicotinic Acids
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Definition
: 2-, 3-, or 4-Pyridinecarboxylic acids. Pyridine derivatives substituted with a carboxy group at the 2-, 3-, or 4-position. The 3-carboxy derivative (NIACIN) is active as a vitamin.
/defic: consider also PELLAGRA; /ther use: coordinate disease with /drug ther, not /diet ther
Pharmacological Action
Vitamin B Complex
Examples
Arecoline
;
Clonixin
;
Etazolate
;
Niacin
;
Niacinamide
;
Niceritrol
;
Niflumic Acid
;
Pipemidic Acid
;
Piromidic Acid
;
Xanthinol Niacinate
Other names
Acids, Nicotinic
Substance
CAS Registry & name
Categories
Source
Drugs
*
6-
(3-
cyclopentyl-
2-
(4-
(trifluoromethyl)-
1H-
imidazol-
1-
yl)propanamido)nicotinic acid
0
*Imidazoles
*Nicotinic Acids
Glucokinase/antagonists & inhibitors.
J Med Chem. 2012 Feb 9;55(3):1318-33.
2-
(5-
(2,5-
dimethylphenoxy)-
2,2-
dimethylpentanoyloxy)ethyl nicotinate
0
*Nicotinic Acids
Gemfibrozil/*analogs & derivatives.
Eur J Pharm Sci. 2011 Jan 14;43(3):99-108.
1,3-
bis(4,6-
dimethyl-
1H-
nicotinonitrile-
1-
yl)1,3-
dioxy propane
0
*Nicotinic Acids
*Nitriles.
Spectrochim Acta A Mol Biomol Spectrosc. 2011 Sep;79(5):1267-75
nicotinyl tryptophanate
0
*Nicotinic Acids
*Schiff Bases
Tryptophan/*analogs & derivatives.
Radiats Biol Radioecol. 2010 Jul-Aug;50(4): 472-4
nicotinyl tyrosinate
0
*Nicotinic Acids
*Schiff Bases
Tyrosine/*analogs & derivatives.
Radiats Biol Radioecol. 2010 Jul-Aug;50(4): 472-4
N'-
(2-
methyl-
3-
phenylallylidene)nicotinohydrazide
0
*Hydrazines
*Nicotinic Acids.
Spectrochim Acta A Mol Biomol Spectrosc 2010 Oct 15;77(3):687-95
6-
fluoronicotinic acid 2,3,5,6-
tetrafluorophenyl ester
0
*Nicotinic Acids
Fluorine Radioisotopes.
J Med Chem 2010 Feb 25;53(4):1732-40
N-
methylpyridine-
2-
carboxamide
0
*Nicotinic Acids
Ligands.
Appl Radiat Isot 2010 Jan;68(1):90-5
2-
(2-
chlorobenzylamino)-
1-
(2,3-
dihydro-
1H-
inden-
1-
yl)-
1H-
imidazo(4,5-
b)pyridine-
5-
carboxamide
0
*Imidazoles
*Nicotinic Acids
Acetyl-CoA Carboxylase/antagonists & inhibitors.
Bioorg Med Chem Lett 2009 Dec 1;19(23):6507-14
3-
carboxy-
1-
octylcarbamoylmethylpyridinium
0
*Nicotinic Acids.
Proc Natl Acad Sci U S A 2009 Jun 30;106(26):10678-83
sodium 6-
((5-
chloro-
2-
(((4-
chloro-
2-
fluorophenyl)methyl)oxy)phenyl)methyl)-
2-
pyridinecarboxylate
0
*Nicotinic Acids
Receptors, Prostaglandin E/antagonists & inhibitors.
Bioorg Med Chem Lett. 2009 May 1;19(9):2599-603
celangulatin I
0
*Nicotinic Acids
*Sesquiterpenes.
Nat Prod Res 2009;23(5):470-8
celangulatin H
0
*Nicotinic Acids
*Sesquiterpenes.
Nat Prod Res 2009;23(5):470-8
celangulatin G
0
*Nicotinic Acids
*Sesquiterpenes.
Nat Prod Res 2009;23(5):470-8
4-
hydroxy-
2-
methyl-
3-
pyridinecarboxylic acid
0
*Nicotinic Acids.
Dalton Trans 2009 Mar 14;(10):1815-24
1,6-
dimethyl-
4-
hydroxy-
3-
pyridinecarboxylic acid
0
*Nicotinic Acids.
Dalton Trans 2009 Mar 14;(10):1815-24
octyl nicotinate
0
*Nicotinic Acids.
Biopharm Drug Dispos 2008 Jul;29(5):308-10
phenyl nicotinate
0
*Nicotinic Acids.
Biopharm Drug Dispos 2008 Jul;29(5):308-10
3-
amino-
5-
chloro-
6-
methoxy-
4-
methyl-
thieno(2,3-
b)pyridine-
2-
carboxylic acid cyclopropylamide
0
*Nicotinic Acids
*Thiophenes.
Proc Natl Acad Sci U S A 2008 Aug 5;105(31):10978-83
5-
(2-
fluoroethyl) 2,4-
diethyl-
3-
(ethylsulfanylcarbonyl)-
6-
phenylpyridine-
5-
carboxylate
0
*Nicotinic Acids
Fluorine Radioisotopes.
Nucl Med Biol 2008 Jan;35(1):61-6
2-
(2-
(3,4-
dichlorophenyl)-
2,3-
dihydro-
1H-
isoindol-
5-
ylamino)nicotinic acid
0
*Nicotinic Acids
*Isoindoles.
Mol Pharmacol 2008 Mar;73(3):639-51
N-
phenyl-
2-
pyridinecarboxamide
0
*Nicotinic Acids.
Spectrochim Acta A Mol Biomol Spectrosc 2007 Sep;68(1):184-90
HUM 5007
0
*Cholecalciferol
*Ascorbic Acid
*Nicotinic Acids
*Plant Extracts
Dehydroepiandrosterone/*analogs & derivatives.
J Nutr Biochem 2007 Sep;18(9):629-34
meso-
cinchomeronimide
0
*Imides
*Nicotinic Acids.
J Am Chem Soc 2006 Jun 14;128(23):7670-8
KR-
62436
0
*Nicotinic Acids
*Nitriles.
Eur J Pharmacol 2005 Jul 25;518(1):63-70
AEC623892
0
*Anthranilic Acids
*Nicotinic Acids.
Pest Manag Sci 2005 Jul;61(7):705-14
2-
amino-
6-
(2-
(cyclopropylmethoxy)-
6-
hydroxyphenyl)-
4-
piperidin-
4-
yl nicotinonitrile
0
*Nicotinic Acids
*Nitriles.
Clin Cancer Res. 2005 Mar 1;11(5):1694-703
nicotinoyl-
N-
oxysuccinimide
0
*Nicotinic Acids
*Succinimides.
J Biol Chem 2005 Jan 28;280(4):2536-42
pepluanin A
0
*Diterpenes
*Nicotinic Acids.
J Med Chem 2004 Feb 12;47(4):988-92
imazapic
0
*Imidazoles
*Nicotinic Acids.
Pest Manag Sci 2002 Sep;58(9):917-9
4-
hydroxy-
3-
pyridinecarboxylic acid
609-70-1
*Nicotinic Acids.
Rapid Commun Mass Spectrom 2003;17(18):2039-46
Fmoc-
N-
epsilon-
(Hynic-
Boc)-
lysine
0
*Nicotinic Acids
Lysine/*analogs & derivatives
Ligands.
J Med Chem 2003 Apr 24;46(9):1751-7
nicoboxil
13912-80-6
*Nicotinic Acids.
Plast Reconstr Surg 2003 Mar;111(3):1207-11
diflufenzopyr
109293-97-2
*Nicotinic Acids
*Semicarbazones.
Pest Manag Sci 2002 Oct;58(10):1002-14
4-
(2-
(p-
hydroxybenzoyl)vinyl)phenyl nicotinate
0
*Benzylidene Compounds
*Nicotinic Acids.
Leuk Res 2003 Jan;27(1):57-64
dichlorotetrakis(nicotinic acid)ruthenium(II)
0
*Nicotinic Acids
*Organometallic Compounds
Ruthenium.
J Inorg Biochem 2001 Sep;86(2-3):587-94
azidobenzoylneonicotinoid
0
*Nicotinic Acids.
J Neurochem 2001 Sep;78(6):1359-66
azidoneonicotinoid
0
*Nicotinic Acids.
J Neurochem 2001 Sep;78(6):1359-66
methyl 2-
methoxy-
6-
methylaminopyridine-
3-
carboxylate
0
*Nicotinic Acids.
Chem Pharm Bull (Tokyo) 2000 Dec;48(12):1847-53
5-
bromo-
2-
methoxy-
6-
methylaminopyridine-
3-
carboxylic acid
0
*Nicotinic Acids.
Chem Pharm Bull (Tokyo) 2000 Dec;48(12):1847-53
hydroxynicotinic acid phosphate
0
*Nicotinic Acids.
Biofizika 2001 Jan-Feb;46(1):34-8
SC 71952
0
*Nicotinic Acids.
J Lipid Res 2000 Oct;41(10):1604-14
dichlorotetrakis(3,5-
pyridinedicarboxylic acid)ruthenium(II)
0
*Nicotinic Acids
*Organometallic Compounds.
J Inorg Biochem 1999 Sep 30;76(3-4):153-63
2-
nitrooxyethyl 1,4-
dihydro-
2,6-
dimethyl-
3-
nitro-
4-
(2-
trifluoromethylphenyl)pyridine-
5-
carboxylate
0
*Nicotinic Acids.
Bioorg Med Chem Lett 1999 Sep 6;9(17):2613-4
6-
hydrazinopyridine-
3-
carboxylic acid
0
*Hydrazines
*Nicotinic Acids
Ligands.
Nucl Med Biol 1999 May;26(4):389-96
diethyl 1,4-
dihydro-
2,6-
dimethyl-
4-
(4'-
(4H-
4-
oxo-
1-
benzopyran-
2-
yl)phenyl)-
3,5-
pyridinedicarboxylate
0
*Chromones
*Nicotinic Acids.
Pharmazie 1999 Apr;54(4):255-9
OPC 13463
73372-63-1
*Nicotinic Acids
Nifedipine/*analogs & derivatives.
Drug Metab Dispos 1999 Feb;27(2):303-8
3-
methyl-
5-
phenylethyl 1,4-
dihydro-
2,6-
dimethyl-
4-
(1-
methyl-
2-
methylsulfonyl-
5-
imidazolyl)-
3,5-
pyridinedicarboxylate
0
*Nicotinic Acids.
Pharm Acta Helv 1998 Jul;73(2):75-9
2-
aminonicotinic acid
5345-47-1
*Nicotinic Acids.
Acta Crystallogr C 1997 Oct 15;53( Pt 10):1427-9
N-
methyl-
5-
hydroxynicotinic acid
0
*Nicotinic Acids.
Biochemistry 1997 Nov 11;36(45):13856-64
FG 5974
0