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Niacin

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Definition: A water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and NADP. It has PELLAGRA-curative, vasodilating, and antilipemic properties.  /defic: consider also PELLAGRA; /ther use: coordinate disease with /drug ther, not /diet ther   
Pharmacological Action Hypolipidemic Agents; Vasodilator Agents; Vitamin B Complex 		Other names Nicotinic Acid; Zinc Salt, Niacin; Tosylate, Niacin; Tartrate, Niacin; Sodium Salt, Niacin; Salt, Niacin Zinc; Salt, Niacin Sodium; Salt, Niacin Potassium; Salt, Niacin Magnesium; Salt, Niacin Lithium; Salt, Niacin Calcium; Salt, Niacin Ammonium; Salt, Niacin Aluminum; Potassium Salt, Niacin; Nicotinate, Lithium; Nico400; Nico 400; Magnesium Salt, Niacin; Lithium Salt, Niacin; Hydrochloride, NiacinDrugs* : NIASPAN; NIACIN; NIACOR; WAMPOCAP; NIASPAN TITRATION STARTER PACK; NICOLAR
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
ocuvite plus lutein  0   *Ascorbic Acid *Niacin *Riboflavin *Vitamin E *Lutein *beta Carotene Dietary Supplements. Exp Eye Res. 2007 Apr;84(4):718-28.
Simcor  0   *Niacin *Simvastatin Drug Combinations Hypolipidemic Agents. Drugs R D. 2010;10(4):253-60SIMCOR
6-hydrazinonicotinic acid  0   Niacin/*analogs & derivatives. Dalton Trans. 2011 Jun 21;40(23):6260-7
3-(1H-benzo(d)(1,2,3)triazol-1-yl)-1-oxo-1-m-tolylpropan-2-yl-nicotinate  0   *Triazoles Niacin/*analogs & derivatives. Spectrochim Acta A Mol Biomol Spectrosc. 2011 Jun;79(1):219-25
hydroxy wilfordic acid  0   *Hydroxybutyrates Niacin/*analogs & derivatives. Arch Pharm Res 2009 Dec;32(12):1673-9
(5-(2-((benzoyloxycarbonylethylamino)methyl)-4-trifluoromethylphenyl)pyridin-3-yl)acetic acid  0   *Benzylamines Niacin/*analogs & derivatives. J Pharmacol Exp Ther 2010 Mar;332(3):764-75
4-aminopyridinium nicotinate  0   *Pyridinium Compounds Niacin/*analogs & derivatives. Acta Crystallogr C. 2009 Jul;65(Pt 7):o361-4
2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-3-ethoxy-carbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine  0   Niacin/*analogs & derivatives. Biophys J 2009 May 20;96(10):3917-25
3-methyl-5-(tetrahydrofuran-2-yl)methyl 2,6-dimethyl-4-(2'-nitrophenyl)pyridine-3,5-dicarboxylate  0   *Furans Niacin/*analogs & derivatives. Vascul Pharmacol 2008 Aug;49(2-3):91-6
2,6-dimethyl-5-methoxycarbonyl-4-(2'-nitrophenyl)pyridine-3-carboxylic acid  0   Niacin/*analogs & derivatives. Vascul Pharmacol 2008 Aug;49(2-3):91-6
2-(4-phenyl-5-(2-pyridyl)-4H-1,2,4-triazol-3-yl)nicotinic acid  0   *Triazoles Niacin/*analogs & derivatives. Acta Crystallogr C 2008 Oct;64(Pt 10):o574-7
2-((1H-pyrrolo(2,3-b)pyridine-4-yl)methylamino)-5- fluoronicotinic acid  0   *Pyrroles Niacin/*analogs & derivatives. J Org Chem 2006 May 12;71(10):4021-3
amlodipine nicotinate  0   *Niacin *Amlodipine. Int J Clin Pharmacol Ther 2006 Dec;44(12):641-7
ethyl 3-cyano-4-(5'-nitro-2'-furyl)-2,6-dimethyl-1,4-dihydropyridine-5-carboxylate  0   *Nitrofurans Niacin/*analogs & derivatives. Bioelectrochemistry 2006 Sep;69(1):104-12
myristyl nicotinate  0   Niacin/*analogs & derivatives. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Dec 27;829(1-2):123-35
SPF 32629 B  0   *Pyridones Niacin/*analogs & derivatives. J Antibiot (Tokyo) 2006 Jan;59(1):29-34
glycyrrhizic acid penta-O-nicotinate  0   Niacin/*analogs & derivatives Glycyrrhizic Acid/*analogs & derivatives. Vestn Ross Akad Med Nauk. 2004;(11):42-6
nicotinic acid benzylamide  0   *Benzyl Compounds Niacin/*analogs & derivatives. Acta Pol Pharm. 2003 Sep-Oct;60(5):335-7
isonicotinic acid benzylamide  0   *Benzyl Compounds Niacin/*analogs & derivatives. Acta Pol Pharm. 2003 Sep-Oct;60(5):335-7
silver 2-mercaptonicotinate  0   *Organometallic Compounds Niacin/*analogs & derivatives Silver. Inorg Chem. 2003 Dec 1;42(24):8028-32
HCAR3 protein, human  0   *Receptors, Nicotinic *Receptors, G-Protein-Coupled Niacin Adipocytes. J Med Chem. 2006 Feb 23;49(4):1227-30; Nat Med 2003 Mar;9(3):352-5
lovastatin-niacin combination  0   *Lovastatin *Niacin Drug Combinations. J Clin Hypertens (Greenwich) 2002 Mar-Apr;4(2):146-7ADVICOR
4,4'-bis-methyl-5,5'-((1-methyltrimethylene)di)methylnicotinate  0   Niacin/*analogs & derivatives. Nat Prod Lett 2001;15(2):131-7
H 394-84  0   *Phenylurea Compounds Niacin/*analogs & derivatives Receptors, Neuropeptide Y/antagonists & inhibitors. Eur J Pharmacol 2001 Apr 20;418(1-2):95-104
5-bromonicotinic acid N-hydroxysuccinimide ester  0   *Succinimides Niacin/*analogs & derivatives. Rapid Commun Mass Spectrom 1998;12(10):603-8
RX 549  0   Niacin/*analogs & derivatives. Anticancer Res 1997 Jan-Feb;17(1A):393-400
RX 512  0   Niacin/*analogs & derivatives. Anticancer Res 1997 Jan-Feb;17(1A):393-400
TP 680  0   Cysteine/*analogs & derivatives Niacin/*analogs & derivatives Receptors, Cholecystokinin/antagonists & inhibitors. Br J Pharmacol 1996 Apr;117(7):1558-64
nicofuranose  15351-13-0   Niacin/*analogs & derivatives.
Pharma Action Vasodilator Agents
dithionicotinic acid  0   Niacin/*analogs & derivatives. J Toxicol Environ Health 1996 Jun 7;48(2):187-95
phenytoin-1-methylnicotininate  0   Niacin/*analogs & derivatives Phenytoin/*analogs & derivatives. Biol Pharm Bull 1994 Oct;17(10):1425-9
thiazopyr  117718-60-2   *Thiazoles Niacin/*analogs & derivatives Herbicides. Xenobiotica 1994 Aug;24(8):729-34
Antagonic-Stress  0   *Meclofenoxate *Niacin *Orotic Acid Drug Combinations. Ann N Y Acad Sci 1994 Jun 30;717:315-31
imazapyr  81334-34-1   *Imidazoles Niacin/*analogs & derivatives. Am Ind Hyg Assoc J 1992 Apr;53(4):265-72
nicotinylalanine  137548-54-0   Alanine/*analogs & derivatives Niacin/*analogs & derivatives. J Neurochem 1991;57(5):1630
5-iodonicotinic acid  15366-65-1   Niacin/*analogs & derivatives. Bioconjug Chem 1991;2(1):50
trimag  97697-84-2 Magnesium, bis(2-hydroxypropanoato-O1,O2)-, (T-4)-, mixt. with magnesium diformate and magnesium di-3-pyridinecarboxylate  *Formic Acids *Lactates *Niacin Drug Combinations Magnesium. Rev Med Chir Soc Med Nat Iasi 1984;88(1):145
Transvasin  0   *Niacin *Benzocaine *Salicylates Drug Combinations. Q J Med 1985;54(215):229
6-aminonicotinic acid  3167-49-5   Niacin/*analogs & derivatives. J Gen Microbiol 1984;130(Pt 11):2873
Deep-Heat  92172-29-7 3-Pyridinecarboxylic acid, methyl ester, mixt. with ethyl 2-hydroxybenzoate, 2-hydroxyethyl 2-hydroxybenzoate and methyl 2-hydroxybenzoate  *Niacin *Salicylates. Ann Rheum Dis 1984;43(3):411
efavit  87495-27-0 L-Ascorbic acid, mixt. with 5-hydroxy-6-methyl-3,4-pyridinedimethanol, 3-pyridinecarboxylic acid and zinc sulfate (1:1)  *Ascorbic Acid *Niacin *Pyridoxine *Zinc Compounds Drug Combinations. Scand J Rheumatol 1983;12(2):85

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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