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Receptors, Nicotinic

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Definition: One of the two major classes of cholinergic receptors. Nicotinic receptors were originally distinguished by their preference for NICOTINE over MUSCARINE. They are generally divided into muscle-type and neuronal-type (previously ganglionic) based on pharmacology, and subunit composition of the receptors.      Other names Nicotinic Acetylcholine Receptors; Nicotinic Receptors; Receptors, Nicotinic Acetylcholine; Receptor, Nicotinic Acetylcholine; Receptor, Nicotinic; Acetylcholine Receptors, Nicotinic; Acetylcholine Receptor, Nicotinic; Nicotinic Receptor; Nicotinic Acetylcholine Receptor
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
alpha4 nicotinic acetylcholine receptor, Conus regius  0   *Receptors, Nicotinic *Conotoxins Nicotinic Antagonists. Biochem Pharmacol. 2012 Feb 1;83(3):419-26
nicotinic receptor beta3, mouse  0   *Receptors, Nicotinic. Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):16080-5.
acetylcholine receptor gamma, mouse  0   *Receptors, Nicotinic. J Neurochem 2007 Dec;103(6):2651-64
alpha6beta2 nicotinic acetylcholine receptor  0   *Receptors, Nicotinic.
nAcRbeta-21C protein, Drosophila  0   *Receptors, Nicotinic *Drosophila Proteins.
CHRNA5 protein, mouse  0   *Receptors, Nicotinic. Nature. 2011 Mar 31;471(7340):597-601
PF 4575180  0   *Azabicyclo Compounds Receptors, Nicotinic. Neuropsychopharmacology 2011 Feb;36(3):603-15
CP 601932  0   *Benzazepines Receptors, Nicotinic. Neuropsychopharmacology 2011 Feb;36(3):603-15
CHRNA1 protein, mouse  0   *Receptors, Nicotinic. Lab Invest. 2011 Jan;91(1):106-23
1,2,3,3a,4,8b-hexahydro-2-benzyl-6-N,N-dimethylamino-1-methylindeno(1,2-b)pyrrole  0   *Indenes *Pyrroles Receptors, Nicotinic. Neuropharmacology 2010 Nov;59(6):511-7
5'-(2-fluorophenyl)-spiro(1-azabicyclo(2.2.2)octane-3,2'(3'H)-furo(2,3-b)pyridine)  0   *Spiro Compounds *Azabicyclo Compounds Receptors, Nicotinic. Eur J Pharmacol 2010 Oct 25;645(1-3):63-9
Hcar2 protein, rat  0   *Receptors, Nicotinic *Receptors, G-Protein-Coupled. Bioorg Med Chem Lett 2010 Sep 15;20(18):5426-30
3-((2-pyrrolidinyl)methoxy)-5-phenylaminopyridine  0   *Aminopyridines *Pyrrolidines Receptors, Nicotinic. J Med Chem 2010 Oct 14;53(19):6973-85
5-bromo-3-oxa-4,11-diazatricyclo(6.2.1.0(2,6))undec-4-ene  0   *Heterocyclic Compounds, 3-Ring Ligands Receptors, Nicotinic. Bioorg Med Chem 2010 Jun 15;18(12):4498-508
3-bromo-5-oxa-4,10-diazatricyclo(6.3.1.0(2,6))dodec-3-ene  0   *Heterocyclic Compounds, 3-Ring Ligands Receptors, Nicotinic. Bioorg Med Chem 2010 Jun 15;18(12):4498-508
1-(6-(4-fluorophenyl)pyridin-3-yl)-3-(4-piperidin-1-ylbutyl)urea  0   *Pyridines Urea/*analogs & derivatives Receptors, Nicotinic. J Med Chem 2010 Jun 10;53(11):4379-89
spiro(1-azabicyclo(2.2.2)octane-3,2'(3H)-furo(2,3-b)pyridine)  0   *Furans *Quinuclidines Receptors, Nicotinic. Biochem Pharmacol 2009 Oct 1;78(7):880-8
N-(2-(pyridin-3-ylmethyl)-1-azabicyclo(2.2.2)oct-3-yl)-1-benzofuran-2-carboxamide  0   *Benzofurans *Quinuclidines Receptors, Nicotinic. Biochem Pharmacol 2009 Oct 1;78(7):803-12
CHRNB3 protein, human  0   *Receptors, Nicotinic. Neuropsychopharmacology 2009 Feb;34(3):698-706
CHRNG protein, human  0   *Receptors, Nicotinic. Zhonghua Bing Li Xue Za Zhi 2003 Oct;32(5):413-6
Lev-1 protein, C elegans  0   *Receptors, Nicotinic *Caenorhabditis elegans Proteins Protein Subunits. FASEB J 2008 Sep;22(9):3247-54
Lev-8 protein, C elegans  0   *Receptors, Nicotinic *Caenorhabditis elegans Proteins Protein Subunits. FASEB J 2008 Sep;22(9):3247-54
HCAR2 protein, human  0   *Receptors, Nicotinic *Receptors, G-Protein-Coupled.
desnitroimidacloprid  0   *Pyridines *Imidazolines Receptors, Nicotinic. Proc Natl Acad Sci U S A 2008 May 27;105(21):7606-11
UNC-29 protein, C elegans  0   *Receptors, Nicotinic *Caenorhabditis elegans Proteins. Cell 2008 May 30;133(5):903-15
2-(5-methylhexahydropyrrolo(3,4-c)pyrrol-2-yl)xanthen-9-one  0   *Pyrroles *Xanthones Receptors, Nicotinic. Br J Pharmacol 2008 Mar;153(5):1054-61
ACR-23 protein, C elegans  0   *Receptors, Nicotinic *Caenorhabditis elegans Proteins. Nature. 2008 Mar 13;452(7184):176-80
Chrna10 protein, mouse  0   *Receptors, Nicotinic Protein Subunits. Proc Natl Acad Sci U S A 2007 Dec 18;104(51):20594-9
nicotinic receptor alpha5 subunit, mouse  0   *Receptors, Nicotinic. J Neurochem 2007 Oct;103(1):204-15
CHRNA1 protein, human  0   *Receptors, Nicotinic. Nature 2007 Aug 23;448(7156):934-7
alphaC-conotoxin PrXA  0   *Conotoxins Receptors, Nicotinic. Biochemistry 2007 Jul 31;46(30):8717-24
N-(1-azabicyclo(2.2.2)oct-3-yl)-7-(2-(methoxy)phenyl)-1-benzofuran-2-carboxamide  0   *Benzofurans *Quinuclidines Receptors, Nicotinic. J Pharmacol Exp Ther 2007 May;321(2):716-25
CHRNB1 protein, human  0   *Receptors, Nicotinic. Hum Genet 2006 Oct;120(3):381-9
alpha-conotoxin BuIA, Conus bullatus  0   *Conotoxins Receptors, Nicotinic. J Biol Chem 2005 Jan 7;280(1):80-7
N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide  0   *Quinuclidines *Bicyclo Compounds, Heterocyclic Receptors, Nicotinic. J Med Chem 2006 Jul 13;49(14):4425-36
3'-(3-methylbenzo(b)thiophen-5-yl)spiro(1-azabicyclo(2.2.2)octane-3,5'-oxazolidin)-2'-one  0   *Oxazoles *Quinuclidines Receptors, Nicotinic. J Med Chem 2006 Jul 13;49(14):4374-83
nicotinic acetylcholine receptor delta, zebrafish  0   *Receptors, Nicotinic *Zebrafish Proteins. J Neurosci 2004 Jun 16;24(24):5475-81
nicotinic receptor beta3, rat  0   *Receptors, Nicotinic. Neuropharmacology 2006 Jan;50(1):36-46
chrna1 protein, zebrafish  0   *Receptors, Nicotinic *Zebrafish Proteins. J Cell Sci 2005 Nov 15;118(Pt 22):5181-90
CHRNE protein, human  0   *Receptors, Nicotinic. Hum Genet 2005 Jul;117(2-3):295
alphaA-conotoxin OIVB, Conus obscurus  0   *Conotoxins Receptors, Nicotinic/antagonists & inhibitors. J Neurosci 2005 Jan 19;25(3):732-6
Chrne protein, mouse  0   *Receptors, Nicotinic. Nucleic Acids Res 1990 Nov 25;18(22):6714
2,2,6,6-tetramethylpiperidin-4-yl heptanoate  0   *Heptanoic Acids *Piperidines Receptors, Nicotinic/antagonists & inhibitors. Mol Pharmacol 2005 Jun;67(6):1977-90
N-(3-fluorobenzyl)-N-methylethanolamine  0   *Ethanolamines Receptors, Nicotinic/agonists. J Alzheimers Dis 2004 Dec;6(6 Suppl):S85-92
3'-(5-chlorothiophen-2-yl)spiro-1-azabicyclo(2.2.2)octane-3,5'-(1',3')-oxazolidin-2'-one  0   *Oxazoles *Quinuclidines Receptors, Nicotinic/agonists. J Med Chem 2005 Apr 7;48(7):2678-86
Chrna5 protein, rat  0   *Receptors, Nicotinic. J Biol Chem 1990 Mar 15;265(8):4472-82
Chrna9 protein, rat  0   *Receptors, Nicotinic.
CHRNA9 protein, human  0   *Receptors, Nicotinic.
alpha6beta4beta3alpha5 nicotinic receptor, human  0   *Receptors, Nicotinic. J Pharmacol Exp Ther 2005 Feb;312(2):619-26
Chrnb1 protein, mouse  0   *Receptors, Nicotinic. Circulation 2004 Aug 10;110(6):713-7
CHRNA10 protein, human  0   *Receptors, Nicotinic. Life Sci. 2004 Dec 3;76(3):263-80
1,2,2a,5,5a,6,7,8,8a-nonahydro-4,6,8-trimethylquinolizino(1,8-ae)pyrrole  0   *Heterocyclic Compounds, 3-Ring Receptors, Nicotinic/antagonists & inhibitors. Dev Biol 2004 Oct 15;274(2):1061-9
4-allyl-8-ethylquinolizidine  0   *Quinolizines Receptors, Nicotinic/antagonists & inhibitors. Dev Biol 2004 Oct 15;274(2):1061-9
4-(6-heptenyl)-8-methylindolizidine  0   *Indolizines Receptors, Nicotinic/antagonists & inhibitors. Dev Biol 2004 Oct 15;274(2):1061-9
Unc-63 protein, C elegans  0   *Receptors, Nicotinic *Caenorhabditis elegans Proteins. J Biol Chem 2004 Oct 8;279(41):42476-83
nAcRalpha-30D protein, Drosophila  0   *Receptors, Nicotinic *Drosophila Proteins. Genetics 2002 Apr;160(4):1519-33
chrnb3a protein, zebrafish  0   *Receptors, Nicotinic. Gene Expr Patterns 2003 Dec;3(6):747-54
chrna7 protein, zebrafish  0   *Receptors, Nicotinic. Gene Expr Patterns 2003 Dec;3(6):747-54
chrna2a protein, zebrafish  0   *Receptors, Nicotinic. Gene Expr Patterns 2003 Dec;3(6):747-54
acantoxin IVa, Acanthophis  0   *Elapid Venoms *Peptides Receptors, Nicotinic/antagonists & inhibitors. Biochem Pharmacol 2004 Jul 15;68(2):383-94
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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