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Bicyclo Compounds, Heterocyclic

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Definition: A class of saturated compounds consisting of two rings only, having two or more atoms in common, containing at least one hetero atom, and that take the name of an open chain hydrocarbon containing the same total number of atoms. (From Riguady et al., Nomenclature of Organic Chemistry, 1979, p31)  DF: BICYCLO CPDS HETEROCYCLIC    Other names Cpds, Bicyclic Heterocyclic; Bicyclic Heterocyclic Compounds; Heterocyclic Compounds, Bicyclic; Compounds, Heterocyclic Bicyclo; Compounds, Bicyclic Heterocyclic; Bicyclic Heterocyclic Cpds; Heterocyclic Bicyclo Compounds; Heterocyclic Cpds, Bicyclic
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
GSK923295  0   *Bicyclo Compounds, Heterocyclic Sarcosine/*analogs & derivatives. Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5839-44.
2-nitro-6,7-dihydro-5H-imidazo(2,1-b)(1,3)oxazin-6-yl 4-(4-(trifluoromethoxy)phenyl)piperazine-1-carboxylate  0   *Piperazines *Bicyclo Compounds, Heterocyclic. J Med Chem. 2012 Jan 12;55(1):312-26.
2-fluoro-N-methyl-4-(7-(quinolin-6-yl-methyl)imidazo(1,2-b)(1,2,4)triazin-2-yl)benzamide  0   *Benzamides *Bicyclo Compounds, Heterocyclic. Clin Cancer Res. 2011 Nov 15;17(22):7127-38.
N-(2-(4-((3-chloro-4-(3-(trifluoromethyl)phenoxy)phenyl)amino)-5H-pyrrolo(3,2-d)pyrimidin-5-yl)ethyl)-3-hydroxy-3-methylbutanamide  0   *Hydroxybutyrates *Bicyclo Compounds, Heterocyclic Receptor, Epidermal Growth Factor/antagonists & inhibitors. J Med Chem. 2011 Dec 8;54(23):8030-50.
2-(6-((3,4-dihydro-2H-chromen-2-ylmethyl)amino)hexyl)tetrahydro-1H-pyrrolo(1,2-c)imidazole-1,3(2H)-dione  0   *Benzopyrans *Bicyclo Compounds, Heterocyclic Receptor, Serotonin, 5-HT1A Serotonin 5-HT1 Receptor Agonists. J Med Chem. 2011 Dec 8;54(23):7986-99.
5-(4-chloro-3-(4-ethoxybenzyl)phenyl)-1-hydroxymethyl-6,8-dioxabicyclo(3.2.1)octane-2,3,4-triol  0   *Bicyclo Compounds, Heterocyclic. Drug Metab Dispos. 2011 Sep;39(9):1609-19.
SB 747651A  0   *Oxadiazoles *Bicyclo Compounds, Heterocyclic. Biochem J. 2012 Jan 1;441(1):347-57.
8-(4-methoxyphenyl)-4-oxo-4,6,7,8-tetrahydroimidazo(2,1-c)(1,2,4)triazine-3-carbohydrazide  0   *Hydrazines *Bicyclo Compounds, Heterocyclic Adenosine A2 Receptor Antagonists. Chem Biol Interact. 2012 Jan 5;195(1):18-24.
N-(3-(5-cyano-6-methylpyridin-2-yloxy)-2,2,4,4-tetramethylcyclobutyl)imidazo(1,2-a)pyrimidine-3-carboxamide  0   *Cyclobutanes *Bicyclo Compounds, Heterocyclic Androgen Receptor Antagonists. J Med Chem. 2011 Nov 10;54(21):7705-12.
N-(3-((5-cyano-6-methylpyridin-2-yl)oxy)-2,2,4,4-tetramethylcyclobutyl)imidazo(1,2-a)pyrimidine-3-carboxamide  0   *Cyclobutanes *Bicyclo Compounds, Heterocyclic Androgen Receptor Antagonists. J Med Chem. 2011 Nov 10;54(21):7693-704.
1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno(3,2-d)pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one  0   *Pyrimidines *Bicyclo Compounds, Heterocyclic Phosphatidylinositol 3-Kinase/antagonists & inhibitors. J Med Chem. 2011 Nov 10;54(21):7579-87.
BPR1K653  0   *Phenylurea Compounds *Bicyclo Compounds, Heterocyclic. PLoS One. 2011;6(8):e23485.
1,3a,6a-triazapentalene  0   *Bicyclo Compounds, Heterocyclic. J Am Chem Soc. 2011 Aug 3;133(30):11466-9
3-(2'-fluoro-6',7'-dihydrospiro(piperidine-4,4'-thieno(3,2-c)pyran)-1-yl)-2-(2-fluorobenzyl)-N-methylpropanamide  0   *Spiro Compounds *Bicyclo Compounds, Heterocyclic Carbon Radioisotopes Ligands. J Nucl Med 2011 Oct;52(10):1638-45
N-(2-(2-(4-(4-(2-hydroxypropyl)piperazin-1-yl)-2-methoxyphenylamino)pyrrolo(2,1-f)(1,2,4)triazin-7-yl)phenyl)-N-methylmethanesulfonamide  0   *Sulfonamides *Bicyclo Compounds, Heterocyclic. J Med Chem 2011 Sep 22;54(18):6328-41
2-bromo-N-(4-(8-methylimidazo(1,2-a)pyridin-2-yl)phenyl)benzamide  0   *Benzamides *Bicyclo Compounds, Heterocyclic. PLoS One 2011;6(6):e19904
Sioc145 compound  0   *Bicyclo Compounds, Heterocyclic. Cell Res 2011 Apr;21(4):588-99
8-oxabicyclo(3.2.1)oct-3-en-2-one  0   *Bicyclo Compounds, Heterocyclic. Org Lett. 2011 Jul 15;13(14):3620-3
6-(6-(1-methyl-1H-pyrazol-4-yl)imidazo(1,2-b)pyridazin-3-ylmethyl)quinoline  0   *Quinolines *Bicyclo Compounds, Heterocyclic. Cancer Res 2011 Aug 1;71(15):5255-64
ceestatin  0   *Lactones *Bicyclo Compounds, Heterocyclic Hydroxymethylglutaryl-CoA Synthase/antagonists & inhibitors. J Infect Dis 2011 Aug;204(4):609-16
2-cyclohexylimino-6-methyl-6,7-dihydro-5H-benzo(1,3)oxathiol-4-one  0   *Bicyclo Compounds, Heterocyclic. Exp Mol Med 2011 May 31;43(5):313-21
marilzabicycloallene A  0   *Hydrocarbons, Brominated *Bicyclo Compounds, Heterocyclic. Org Lett. 2011 May 20;13(10):2690-3
1-methyl-2-((3-methyl-4-(4-trifluoromethyl-2-fluoro)phenyl)piperidin-1-ylmethyl)-1H-imidazo(4,5-b)pyridine  0   *Piperidines *Bicyclo Compounds, Heterocyclic Receptors, Metabotropic Glutamate/agonists. J Med Chem 2011 Mar 24;54(6):1724-39
1-(6-((2-(dimethylamino)ethyl)(methyl)amino)-1,3-dimethyl-1H-pyrazolo(3,4-b)pyridine-5-carbonyl)-3-(3-isopropoxyphenyl)urea  0   *Phenylurea Compounds *Bicyclo Compounds, Heterocyclic. J Med Chem 2011 Mar 24;54(6):1667-81
6,7,8-trioxabicyclo(3.2.2)nonane  0   *Bicyclo Compounds, Heterocyclic. J Phys Chem B. 2011 Jan 20;115(2):333-46
7-amino-8-oxo-3-vinyl-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid  0   *Vinyl Compounds *Bicyclo Compounds, Heterocyclic. Spectrochim Acta A Mol Biomol Spectrosc. 2011 Feb;78(2):660-9
(1S,5R)-(((4S)-azepan-4-ylamino)carbonyl)-7-oxo-2,6-diazabicyclo(3.2.0)heptane-6-sulfonic acid  0   *Bicyclo Compounds, Heterocyclic beta-Lactamases/antagonists & inhibitors. J Pharm Sci. 2010 Dec;99(12):4973-81
1-(2-fluoro-4-((5-methyl-5H-pyrrolo(3,2-d)pyrimidin-4-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea  0   *Phenylurea Compounds *Bicyclo Compounds, Heterocyclic Vascular Endothelial Growth Factor Receptor-2/antagonists & inhibitors. Bioorg Med Chem 2010 Oct 15;18(20):7260-73
1-(2-chloro-4-((5-methyl-5H-pyrrolo(3,2-d)pyrimidin-4-yl)oxy)phenyl)-3-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)urea  0   *Phenylurea Compounds *Bicyclo Compounds, Heterocyclic Vascular Endothelial Growth Factor Receptor-2/antagonists & inhibitors Receptor, Fibroblast Growth Factor, Type 1/antagonists & inhibitors. Bioorg Med Chem 2010 Oct 15;18(20):7150-63
7-azabicyclo(2.2.1)heptane-2-amine  0   *Bicyclo Compounds, Heterocyclic. Org Lett. 2010 Nov 5;12(21):4964-7
CGI 1746  0   *Benzamides *Bicyclo Compounds, Heterocyclic. Nat Chem Biol 2011;7(1):41-50
CM 269  0   *Bicyclo Compounds, Heterocyclic Aspartic Acid/*analogs & derivatives Caspase 1/antagonists & inhibitors. Chem Biol 2010 Sep 24;17(9):999-1007
1,2-dideoxy-2'-propylglucopyranoso(2,1-d)-delta 2'-thiazoline  0   *Bicyclo Compounds, Heterocyclic. J Biol Chem 2008 Dec 12;283(50):34687-95
GDP 366  0   *Phenylurea Compounds *Bicyclo Compounds, Heterocyclic. Cancer Biol Ther 2010 Apr;9(8):640-50
abyssomicin I  0   *Bicyclo Compounds, Heterocyclic. J Nat Prod. 2010 Nov 29;73(11):1943-6
poly(3,4-propylenedioxythiophene)  0   *Polymers *Bicyclo Compounds, Heterocyclic. Chemphyschem 2010 Sep 10;11(13):2814-9
7-(2,6-difluoro-4-(5-methyl-2,5-diazabicyclo(2.2.1)heptan-2-yl)phenyl)-3-(1H-indazol-4-yl)-2-(pyridin-4-yl)pyrazolo(1,5-a)pyrimidine  0   *Bicyclo Compounds, Heterocyclic Proto-Oncogene Proteins B-raf/antagonists & inhibitors. J Med Chem 2010 Nov 11;53(21):7874-8
dinaciclib  0   *Pyridinium Compounds *Bicyclo Compounds, Heterocyclic Cyclin-Dependent Kinases/antagonists & inhibitors. Mol Cancer Ther 2010 Aug;9(8):2344-53
AE9C90CB  0   *Bicyclo Compounds, Heterocyclic. Br J Pharmacol. 2010 Jul;160(5):1119-27
6-(2-(methylamino)propanamido)-5-oxo-9-(2-phenylacetamido)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)decahydropyrrolo(1,2-a)azocine-3-carboxamide  0   *Bicyclo Compounds, Heterocyclic Alanine/*analogs & derivatives Inhibitor of Apoptosis Proteins/antagonists & inhibitors X-Linked Inhibitor of Apoptosis Protein/antagonists & inhibitors. J Med Chem 2010 Sep 9;53(17):6361-7
GW 876008  0   *Pyrazoles *Bicyclo Compounds, Heterocyclic Corticotropin-Releasing Hormone/antagonists & inhibitors. J Pharm Biomed Anal 2010 Nov 2;53(3):517-25
4-(4-(2,3-dihydro-1,4-benzodioxin-6-yl)-1H-pyrazol-3-yl)benzene-1,3-diol  0   *Pyrazoles *Bicyclo Compounds, Heterocyclic. J Pharmacol Sci 2010 Jan;112(1):89-97
N-(4-methyl-3-(1-methyl-7-(6-methylpyridin-3-ylamino)-2-oxo-1,2-dihydropyrimido(4,5-d)pyrimidin-3(4H)-yl)phenyl)-3-(trifluoromethyl)benzamide  0   *Pyrimidinones *Bicyclo Compounds, Heterocyclic. J Med Chem 2010 Aug 12;53(15):5439-48
13-desmethylene-dactylolide  0   *Lactones *Bicyclo Compounds, Heterocyclic. Org Lett. 2010 May 21;12(10):2302-5
(1R,2S,6R)-2-hydroxymethyl-2,6-dimethyl-3-oxabicyclo(4.2.0)octane  0   *Bicyclo Compounds, Heterocyclic Sex Attractants. Org Lett. 2010 Jun 4;12(11):2447-9
Qingrejiedu  0   *Chlorogenic Acid *Flavonoids *Indoles *Bicyclo Compounds, Heterocyclic *Iridoids. Se Pu. 2008 Sep;26(5):599-602
LGP1 compound  0   *Bicyclo Compounds, Heterocyclic Histone Deacetylases. Anticancer Res 2010 Mar;30(3):887-94
CH 4986399  0   *Bicyclo Compounds, Heterocyclic. Anticancer Res 2010 Mar;30(3):873-8
2-(8-(3,5-difluorophenyl)-10-oxo-6,9-diazaspiro(4.5)dec-9-yl)-N-(2'-oxo-1,1',2',3-tetrahydrospiro(indene-2,3'-pyrrolo(2,3-b)pyridin)-5-yl)acetamide  0   *Spiro Compounds *Bicyclo Compounds, Heterocyclic Receptors, Calcitonin Gene-Related Peptide/antagonists & inhibitors. J Pharmacol Exp Ther 2010 Apr;333(1):152-60
jaspine A  0   *Bicyclo Compounds, Heterocyclic. Biosci Biotechnol Biochem 2010 Jan;74(1):152-7
rel-(1S,2R,3R,5S,7R)-methyl 7-caffeoyloxymethyl-2-hydroxy-3-feruloyloxy-6,8-dioxabicyclo(3.2.1)octane-5-carboxylate  0   *Phenylpropionates *Bicyclo Compounds, Heterocyclic. J Nat Prod. 2010 Feb 26;73(2):270-4
rel-(1R,2R,3R,5S,7R)-methyl 7-feruloyloxymethyl-2-feruloyloxy-3-hydroxy-6,8-dioxabicyclo(3.2.1)octane-5-carboxylate  0   *Phenylpropionates *Bicyclo Compounds, Heterocyclic. J Nat Prod. 2010 Feb 26;73(2):270-4
rel-(1S,2R,3R,5S,7R)-methyl 7-feruloyloxymethyl-2-hydroxy-3-feruloyloxy-6,8-dioxabicyclo(3.2.1)octane-5-carboxylate  0   *Phenylpropionates *Bicyclo Compounds, Heterocyclic. J Nat Prod. 2010 Feb 26;73(2):270-4
N-(3-(7-nitro-3-oxobenzo(d)(1,2)selenazol-2(3H)-yl)benzylidene)propan-2-amine oxide  0   *Organoselenium Compounds *Bicyclo Compounds, Heterocyclic. Biochem Biophys Res Commun 2010 Jan 15;391(3):1500-5
1-aza-bicyclo(2.2.2)oct-2-en-3-ylmethyl acetate  0   *Bicyclo Compounds, Heterocyclic. Chem Pharm Bull (Tokyo). 2009 Nov;57(11):1300-2
1-azabicyclo(3.1.0)hexane  0   *Hexanes *Bicyclo Compounds, Heterocyclic. Chem Pharm Bull (Tokyo). 2009 Oct;57(10):1142-6
2-hydroxy-exo-brevicomin  0   *Bicyclo Compounds, Heterocyclic. Org Lett. 2009 Aug 20;11(16):3678-81
colomitide B  0   *Bicyclo Compounds, Heterocyclic. Chem Biodivers 2009 Aug;6(8):1216-23
colomitide A  0   *Bicyclo Compounds, Heterocyclic. Chem Biodivers 2009 Aug;6(8):1216-23
N,N-dipropyl-(2-(8-(2-aminoacetamido)-2-(4-chlorophenyl)imidazo(1,2-a)pyridin-3-yl))acetamide  0   *Acetamides *Bicyclo Compounds, Heterocyclic Ligands. J Control Release 2009 Aug 4;137(3):185-95
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