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Indoles
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Definition
: Benzopyrroles with the nitrogen at the number one carbon adjacent to the benzyl portion, in contrast to ISOINDOLES which have the nitrogen away from the six-membered ring.
Examples
Adrenochrome
;
Alcian Blue
;
Carbazoles
;
Carbolines
;
Cytochalasins
;
Delavirdine
;
Gliotoxin
;
Hydroxytryptophol
;
Ibogaine
;
Indapamide
;
Indican
;
Indigo Carmine
;
Indocyanine Green
;
Indole Alkaloids
;
Indoleacetic Acids
;
Indolequinones
;
Indomethacin
;
Indoramin
;
Iprindole
;
Isatin
;
Methisazone
;
Molindone
;
Oxyphenisatin Acetate
;
Perindopril
;
Skatole
;
Sporidesmins
;
Tryptamines
Substance
CAS Registry & name
Categories
Source
Drugs
*
dimethylindole red
0
*Carbocyanines
*Indoles
Fluorescent Dyes.
Biochemistry. 2012 Mar 27;51(12):2471-85.
3-
ethynyl-
5-
nitroindolyl-
2'-
deoxyriboside triphosphate
0
*Indoles
*Nucleotides.
Nucleic Acids Res. 2012 Mar;40(5):2357-67.
1-
(2-
(18F)fluoro-
3-
pyridyl)-
4-
(2-
isopropyl-
1-
oxo-
isoindoline-
5-
yl)-
5-
methyl-
1H-
1,2,3-
triazole
0
*Indoles
*Triazoles.
J Neurochem. 2012 Apr;121(1):115-24
(1H-
indol-
2-
yl)(4-
(phenylamino)thieno(2,3-
d)pyrimidin-
6-
yl)methanone
0
*Indoles
*Pyrimidines.
Bioorg Med Chem. 2012 Jan 1;20(1):125-36
N-
(2-
(5-
hydroxy-
1H-
indol-
3-
yl)ethyl)-
2-
oxopiperidine-
3-
carboxamide
0
*Indoles
*Piperidines.
Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3540-5.
ethyl-
6-
bromo-
5-
hydroxy-
4-
(imidazol-
1-
yl)-
methyl-
1-
methyl-
2-
(phenylsulfinylmethyl)-
1H-
indole-
3-
carboxylate
0
*Indoles
*Sulfoxides.
Biomed Chromatogr. 2012 Apr;26(4):458-63.
3-
(4-
bromobenzyl)-
5-
(1H-
indol-
3-
yl-
methylene)-
2-
thioxoimidazolidin-
4-
one
0
*Indoles
*Imidazolidines.
Int Immunopharmacol. 2011 Nov;11(11):1816-22.
5-
(1H-
indol-
3-
yl-
methylene)-
2-
thioxo-
imidazolidin-
4-
one
0
*Indoles
*Imidazolidines.
Int Immunopharmacol. 2011 Nov;11(11):1816-22.
(4-
(3-
chloro-
4-
fluorophenylamino)thieno(2,3-
d)pyrimidin-
6-
yl)(5-
hydroxy-
1H-
indol-
2-
yl)methanone
0
*Indoles
*Pyrimidines.
Bioorg Med Chem. 2012 Jan 1;20(1):125-36
(4-
(3-
chlorophenylamino)thieno(2,3-
d)pyrimidin-
6-
yl)(1H-
indol-
2-
yl)methanone
0
*Indoles
*Pyrimidines.
Bioorg Med Chem. 2012 Jan 1;20(1):125-36
N-
(4-
methoxy-
3-
(4-
methylpiperazin-
1-
yl)phenyl)-
1,2-
dihydro-
3-
H-
benzo(e)indole-
3-
carboxamide
0
*Indoles
*Piperazines
Adrenergic alpha-2 Receptor Antagonists.
J Pharmacol Exp Ther. 2012 Mar;340(3):750-64.
(18)F-
ICMT11
0
*Azides
*Indoles
Fluorine Radioisotopes.
Bioorg Med Chem Lett. 2011 Dec 1;21(23):6945-9
methyl 5-
methoxy-
4,5-
dihydroindolo(4,3-
f,g)quinoline-
9-
carboxylate
0
*Indoles
*Quinolines.
Org Lett. 2012 Jan 6;14(1):296-8
6-
hydroxyindole
0
*Indoles.
Org Biomol Chem. 2012 Jan 14;10(2):267-72
5-
(4-
bromobenzyloxy)-
2-
(2-
(5-
methoxyindolyl)ethyl-
1-
carbonyl)-
4H-
chromen-
4-
one
0
*Chromones
*Indoles.
J Med Chem. 2012 Jan 26;55(2):966-70.
N-
(1-
(4-
(methylamino)cyclohexyl)indolin-
6-
yl)thiophene-
2-
carboximidamide
0
*Indoles
*Thiophenes
Nitric Oxide Synthase Type I/antagonists & inhibitors.
J Med Chem. 2012 Jan 26;55(2):943-55.
N-
(cyclopropylsulfonyl)-
1-
((2,5-
difluorophenyl)methyl)-
3-
(1,2-
dihydro-
2-
oxo-
3-
pyridinyl)-
6-
fluoro-
5-
(methyl)-
1H-
indole-
2-
carboxamide
0
*Indoles
*Sulfonamides.
J Med Chem. 2012 Jan 26;55(2):754-65.
3-
(5-
carboxypentanoyl)-
1-
(3-
(4-
octylphenoxy)-
2-
oxopropyl)indole-
5-
carboxylic acid
0
*Indoles
Group IV Phospholipases A2/antagonists & inhibitors.
Br J Dermatol. 2012 Feb;166(2):306-16
N-
((4-
fluorophenyl)(1-
methyl-
1H-
imidazol-
2-
yl)methyl)-
2-
methyl-
3-
(1,2,4-
thiadiazol-
5-
yl)-
1H-
indole-
6-
carboxamide
0
*Indoles
*Thiadiazoles
IMP Dehydrogenase/antagonists & inhibitors.
Eur J Pharmacol. 2012 Jan 5;674(1):58-63.
neosidomycin
0
*Indoles
Deoxyglucose/*analogs & derivatives.
J Org Chem. 2011 Dec 2;76(23):9687-98
6-
(4-
chlorophenyl)-
7H-
(1,3)dioxolo(4,5-
f)indol-
7-
one-
5-
oxide
0
*Indoles.
J Antimicrob Chemother. 2011 Nov;66(11):2566-72
2-
oxocyclopiazonic acid
0
*Indoles.
Biosci Biotechnol Biochem. 2011;75(11):2249-52
N-
(benzoylphenyl)-
5-
chloro-
1H-
indole-
2-
carboxamide
0