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Carbolines

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Definition: A group of pyrido-indole compounds. Included are any points of fusion of pyridine with the five-membered ring of indole and any derivatives of these compounds. These are similar to CARBAZOLES which are benzo-indoles.      Other names Beta Carbolines; Pyrido(4,3-b)Indoles; Beta-Carbolines
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
(2-benzyl-6-carboxy-1-thioxo-1,2,3,4-tetrahydro-beta-carbolin-9-yl)acetic acid  0   *Acetic Acids *Carbolines. Bioorg Med Chem. 2012 Jan 1;20(1):356-67
7-(2-aminopyrimidin-5-yl)-1-((1-cyclopropyl-2,2,2-trifluoroethyl)amino)-5H-pyrido(4,3-b)indole-4-carboxamide  0   *Carbolines *Pyrimidines Janus Kinase 2/antagonists & inhibitors. J Med Chem. 2011 Oct 27;54(20):7334-49.
PM 01183  0   *Carbolines *Heterocyclic Compounds with 4 or More Rings. Mol Cancer Ther. 2011 Aug;10(8):1481-9.
1-(1H-indol-3-yl)-9H-pyrido(3,4-b)indole  0   *Carbolines. Chem Biol Interact. 2011 Sep 5;193(2):119-28
GR30040X compound  0   *Carbolines. Med Chem. 2010 Nov 1;6(6):374-87
3-benzylamino-beta-carboline  0   *Carbolines. Eur J Med Chem. 2011 Feb;46(2):636-46
3,4,5-trimethyl-gamma-carboline  0   *Carbolines. Antiviral Res. 2010 Dec;88(3):263-8
((7R)-7-(((4-fluorophenyl)sulfonyl)(methyl)amino)-6,7,8,9-tetrahydropyrido(1,2-a)indol-10-yl)acetic acid  0   *Carbolines. Mol Pharmacol. 2011 Jan;79(1):69-76
eudistomidin G  0   *Carbolines. Bioorg Med Chem Lett 2010 Jul 15;20(14):4100-3
oppositinine B  0   *Carbolines. Chem Pharm Bull (Tokyo). 2010;58(8):1085-7
oppositinine A  0   *Carbolines. Chem Pharm Bull (Tokyo). 2010;58(8):1085-7
1-formyl-beta-carboline-3-carbxylic acid methyl ester  0   *Carbolines *Formates. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4416-9
6-methyl-1-(indol-3-yl)-2-butyryl-1,2,3,4-tetrahydro-beta-carboline  0   *Carbolines. Bioorg Med Chem 2010 Jun 15;18(12):4167-77
1-(3-hydroxyphenyl)-2-(4-aminobenzoyl)-6-chloro-1,2,3,4-tetrahydro-beta-carboline  0   *Carbolines. Bioorg Med Chem 2010 Jun 15;18(12):4167-77
1-(3-hydroxyphenyl)-2-(beta-aminopropionyl)-8-chloro-1,2,3,4-tetrahydro-beta-carboline  0   *Carbolines. Bioorg Med Chem 2010 Jun 15;18(12):4167-77
strictosidinic acid  0   *Carbolines *Glycosides. Phytomedicine 2010 Mar;17(3-4):289-91
5'-chloro-6,7-difluoro-3-methyl-2,3,4,9-tetrahydrospiro(beta-carboline-1,3'-indol)-2'(1'H)-one  0   *Carbolines. J Med Chem 2010 Jul 22;53(14):5155-64
phenylpropyl-1-methyl-7-methoxyl-9-(3-chlorophenyl)-beta-carboline  0   *Carbolines. Cancer Biol Ther 2009 Dec;8(24):2374-83
aminotadalafil  0   *Carbolines *Benzodioxoles. Rapid Commun Mass Spectrom 2006;20(15):2317-27
N,N-didesmethylgrossularine-1  0   *Carbolines. Mar Drugs 2009;7(4):589-99
N,N-bis-(3-(11H-indolo(3,2-c)quinolin-6-yl)aminopropyl)amine  0   *Carbolines. Bioorg Med Chem 2010 Mar 1;18(5):1948-57
ethyl 3-(8-fluoro-2-methyl-2,3,4,5-tetrahydropyrido(4,3-b)indol-5-yl)propionate dihydrochloride  0   *Carbolines. Eksp Klin Farmakol. 2010 Mar;73(3):28-30
10-hydroxy-11-methoxycanthin-6-one  0   *Carbolines. Nat Prod Commun. 2010 Jan;5(1):17-22
4,9-dimethoxycanthin-6-one  0   *Carbolines. Nat Prod Commun. 2010 Jan;5(1):17-22
hyrtiocarboline  0   *Carbolines. J Nat Prod. 2010 Feb 26;73(2):255-7
quassidine A  0   *Alkaloids *Carbolines. J Nat Prod. 2010 Feb 26;73(2):167-71
tabernine C  0   *Carbolines. J Nat Prod 2009 Jun;72(6):1147-50
tabernine B  0   *Carbolines. J Nat Prod 2009 Jun;72(6):1147-50
tabernine A  0   *Carbolines. J Nat Prod 2009 Jun;72(6):1147-50
5-bromo-8-methoxy-1-methyl-beta-carboline  0   *Alkaloids *Carbolines. J Nat Prod 2009 Apr;72(4):796-8
N2-(2-methylaminobenzoyl)tetrahydro-1H-pyrido(3,4-b)indol-1-one  0   *Carbolines Aldehyde Reductase/antagonists & inhibitors. Yakugaku Zasshi 1967 May;87(5):608-10
1-(3-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido(3,4-b)indole-3-carboxylic acid  0   *Carbolines *Piperazines. Nat Chem Biol 2009 Apr;5(4):220-6
N-octylnortadalafil  0   *Carbolines. Chem Pharm Bull (Tokyo) 2009 Feb;57(2):185-9
1-carboxy-6-hydroxy-3,4-dihydro-beta-carboline  0   *Carbolines. Bioorg Med Chem Lett 2009 Feb 15;19(4):1051-3
8,12-diacetoxymanzamine A  0   *Carbolines. J Nat Prod 2008 Jul;71(7):1218-21
8-methoxymanzamine A  0   *Carbolines. J Nat Prod 2008 Jul;71(7):1218-21
9-methyl-beta-carboline  0   *Carbolines. Neurochem Int 2008 Mar-Apr;52(4-5):688-700
1-styryl-9H-pyrido(3,4-b)indole  0   *Carbolines *Styrenes. J Biol Chem 2008 Mar 28;283(13):8624-33
naucleamide A-10-O-glucopyranoside  0   *Carbolines *Glucosides. Yao Xue Xue Bao 2006 Nov;41(11):1064-7
methoxy-annomontine  0   *Carbolines *Pyrimidines. Magn Reson Chem. 2008 Jan;46(1):69-74
eudistomin Y6  0   *Carbolines. J Nat Prod 2008 Feb;71(2):163-6
dichotomine C  0   *Carbolines. Chem Pharm Bull (Tokyo) 2008 Feb;56(2):237-8
bengacarboline  0   *Carbolines. Bioorg Med Chem Lett 2008 Feb 1;18(3):1212-6
DH334 compound  0   *Carbolines. Cancer Biol Ther 2007 Aug;6(8):1193-9
beta-carboline-3-carboxylic acid N-methylamide  0   *Carbolines. Photochem Photobiol 2007 Nov-Dec;83(6):1455-64
brunnein C  0   *Carbolines. J Nat Prod 2007 Sep;70(9):1529-31
brunnein B  0   *Carbolines. J Nat Prod 2007 Sep;70(9):1529-31
brunnein A  0   *Carbolines. J Nat Prod 2007 Sep;70(9):1529-31
6-bromo-2,3,4,9-tetrahydrocarbolin-1-one  0   *Carbolines. Cancer Sci 2007 Sep;98(9):1402-7
isocyclocapitelline  0   *Carbolines Alkaloids. Org Biomol Chem 2007 May 21;5(10):1519-21
isochrysotricine  0   *Carbolines Alkaloids. Org Biomol Chem 2007 May 21;5(10):1519-21
eudistomin D  0   *Carbolines Alkaloids. Bioorg Med Chem 2007 May 1;15(9):3235-40
brevicolline  0   *Carbolines. Org Lett 2006 Aug 3;8(16):3549-52
flazinamide  0   *Carbolines *Furans. Biochem Biophys Res Commun 2007 Apr 20;355(4):1091-5
N-(6-chloro-7-methoxy-9H-beta-carbolin-8-yl)-2-methylnicotinamide  0   *Carbolines Niacinamide/*analogs & derivatives. Arthritis Rheum. 2006 Oct;54(10):3163-73
2-butyl-5-(4-hydroxyphenyl)-5,6,11,11a-tetrahydro-1H-imidazo(1',5'-1,6)pyrido(3,4-b)indole-1,3(2H)-dione  0   *Carbolines Carbon Radioisotopes. Nucl Med Biol 2006 Jul;33(5):593-7
(6R,12aR)-2-amino-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydropyrazino(1',2'-1,6)pyrido(3,4-b)indole-1,4-dione  0   *Carbolines. Food Addit Contam 2006 May;23(5):446-51
N-hydroxyannomontine  0   *Carbolines *Pyrimidines. J Nat Prod 2006 Feb;69(2):292-4
annomontine  0   *Carbolines *Pyrimidines. J Nat Prod 2006 Feb;69(2):292-4
eudistomin C  0   *Carbolines. J Am Chem Soc. 2005 Nov 2;127(43):15038-9
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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