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Niacinamide

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Definition: An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and PELLAGRA. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake.  /defic: consider also PELLAGRA; /ther use: coordinate disease with /drug ther, not /diet ther   
Pharmacological Action Vitamin B Complex
Examples 6-Aminonicotinamide; Nicorandil; Nikethamide 		Other names Vitamin PP; Vitamin B 3; Nicotinamide; Jenapharm Brand of Niacinamide; Enduramide; Astra Brand of Niacinamide; 3-Pyridinecarboxamide; Niacinamide Pharmagenix Brand; Niacinamide Merck Brand; Niacinamide Jenapharm Brand; Niacinamide Astra Brand; Jenapharm, Nicotins+ņureamid; B3, Vitamin; B 3, Vitamin; 3 Pyridinecarboxamide; Vitamin B3; Pharmagenix Brand of Niacinamide; Papulex; Nicotins+ņureamid Jenapharm; Nicobion
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2-(1-benzylpiperidin-4-yl)amino-N-(3-chlorophenyl)nicotinamide  0   *Piperidines Niacinamide/*analogs & derivatives. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6236-41
4,4'-(1,6-hexamethylenedithio)bis(1-octylpyridinium)  0   *Pyridinium Compounds Niacinamide/*analogs & derivatives. Bioorg Med Chem 2003 Nov 17;11(23):5035-43
3-chloro-N-((1-methylpiperidin-2-yl)(thiophen-3-yl)methyl)-4-(trifluoromethyl)picolinamide  0   *Thiophenes Niacinamide/*analogs & derivatives Glycine Plasma Membrane Transport Proteins/antagonists & inhibitors. PLoS One 2011;6(6):e21322
LS 081  0   *Hydrazones Niacinamide/*analogs & derivatives. J Exp Clin Cancer Res 2011;30:34
2-(nicotinamide)-1,3,4-thiadiazole  0   *Thiadiazoles Niacinamide/*analogs & derivatives Aquaporin 4/antagonists & inhibitors. Neurol Sci 2011 Feb;32(1):113-6
N-(2-(((1-phenyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)carbonyl)amino)ethyl)-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxamide  0   *Pyrazoles Niacinamide/*analogs & derivatives Diacylglycerol O-Acyltransferase/antagonists & inhibitors. Eur J Pharmacol 2011 Jan 15;650(2-3):663-72
1-(1-nicotinoylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea  0   Niacinamide/*analogs & derivatives Phenylurea Compounds Epoxide Hydrolases/antagonists & inhibitors. Eur J Pharmacol 2011 Mar 1;654(1):68-74
5-(4-butoxy-3-chlorophenyl)-N-((2-morpholinopyridin-3-yl)methyl)nicotinamide  0   *Morpholines Niacinamide/*analogs & derivatives. Neuropharmacology 2010 Sep;59(3):201-7
N-(1-amino-1-oxo-3-phenylpropan-2-yl)-6-(thiophen-2-yl)nicotinamide  0   *Thiophenes Niacinamide/*analogs & derivatives. J Med Chem 2010 Aug 12;53(15):5536-48
N'-cyano-N-(3-(4-(pyridin-2-yl)piperazin-1-yl)propyl)isonicotinamidine  0   *Amidines Niacinamide/*analogs & derivatives Ligands Receptor, Serotonin, 5-HT1A. Bioorg Med Chem Lett 2010 May 1;20(9):2978-82
N-(2,3-dihydroxypropyl)-1-((2-fluoro-4-iodophenyl)amino)isonicotinamide  0   Niacinamide/*analogs & derivatives. Br J Haematol 2010 May;149(4):537-49
2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide  0   *Biphenyl Compounds Niacinamide/*analogs & derivatives. Pest Manag Sci 2004 Jan;60(1):8-16
N',N-bis(2-pyridinecarboxamide)-1,2-ethane  0   Niacinamide/*analogs & derivatives. Guang Pu Xue Yu Guang Pu Fen Xi. 2007 Jun;27(6):1176-80
6-methyl-N-(3-((3-(1-methylethoxy)propyl)carbamoyl)-1H-pyrazol-4-yl)pyridine-3-carboxamide  0   *Pyrazoles Niacinamide/*analogs & derivatives Glycogen Synthase Kinase 3/antagonists & inhibitors. Brain Res 2009 Nov 3;1236:148-63
N-(2-(diethylamino)ethyl)-6-fluoronicotinamide  0   Niacinamide/*analogs & derivatives Fluorine Radioisotopes. J Med Chem 2009 Sep 10;52(17):5299-302
N-(N-((3-cyanophenyl)sulfonyl)-4-cyclobutylaminoprolyl)-4-((3',5'-dichloroisonicotinoyl)amino)phenylalanine  0   Niacinamide/*analogs & derivatives Phenylalanine/*analogs & derivatives. J Med Chem 2009 Jun 11;52(11):3499-52
N-(2-(4-(2,3-dihydrobenzo(1,4)dioxin-2-ylmethyl)-(1,4)diazepan-2-yl)ethyl)-2-phenoxynicotinamide  0   *Azepines Niacinamide/*analogs & derivatives Receptors, Adrenergic, alpha-2/antagonists & inhibitors. Bioorg Med Chem Lett 2008 Oct 15;18(20):5689-93
6-(4-fluorophenyl)-2-methyl-N-(2-methylbenzothiazol-5-yl)nicotinamide  0   *Benzothiazoles Niacinamide/*analogs & derivatives. Bioorg Med Chem Lett 2008 Oct 15;18(20):5609-13
hydrazinonictinamide  0   Niacinamide/*analogs & derivatives. World J Gastroenterol. 2008 Apr 14;14(14):2235-40
N-(2-(3,5-di-tert-butyl-4-hydroxyphenyl)-4-oxothiazolidin-3-yl)nicotinamide  0   Niacinamide/*analogs & derivatives. Chem Biol Interact 2008 Feb 15;171(3):363-8
N-(2-(4-methoxyphenyl)-4-oxothiazolidin-3-yl)nicotinamide  0   Niacinamide/*analogs & derivatives. Chem Biol Interact 2008 Feb 15;171(3):363-8
flonicamid  0   Niacinamide/*analogs & derivatives. J Agric Food Chem 2007 Oct 3;55(20):8033-9
N-(2-(3,5-di-tert-butyl-4-hydroxyphenyl)-4-oxo-thiazolidin-3-yl)-nicotinamide  0   Niacinamide/*analogs & derivatives. Arzneimittelforschung. 2007;57(9):616-22
N-(1-(4-methoxybenzenesulfonyl)-2,3-dihydro-1H-indol-7-yl)isonicotinamide  0   *Sulfonamides Niacinamide/*analogs & derivatives. J Pharmacol Exp Ther 2007 Oct;323(1):398-405
AD 101  0   *Piperazines Niacinamide/*analogs & derivatives Receptors, CCR5/antagonists & inhibitors. Proc Natl Acad Sci U S A 2002 Jan 8;99(1):395-400
6-((3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy)-N-methyl-3-pyridinecarboxamide  0   *Benzazepines Niacinamide/*analogs & derivatives Receptors, Histamine H3. J Pharmacol Exp Ther 2007 Jun;321(3):1032-45
tetraaqua-di(nicotinamide) Zn(II)-saccharinate  0   *Organometallic Compounds Niacinamide/*analogs & derivatives Zinc. Spectrochim Acta A Mol Biomol Spectrosc 2007 Apr;66(4-5):1288-90
motesanib diphosphate  857876-30-3   *Indoles Niacinamide/*analogs & derivatives Proto-Oncogene Proteins c-kit. Clin Colorectal Cancer 2006 Nov;6 Suppl 1:S30-4
N-(3-aminobenzyl)-6-(4-((3-fluorobenzyl)oxy)phenoxy)nicotinamide  0   Niacinamide/*analogs & derivatives Sodium-Calcium Exchanger/antagonists & inhibitors. Mol Pharmacol 2006 Dec;70(6):2075-83
N-(6-chloro-7-methoxy-9H-beta-carbolin-8-yl)-2-methylnicotinamide  0   *Carbolines Niacinamide/*analogs & derivatives. Arthritis Rheum. 2006 Oct;54(10):3163-73
1-methyl-N'-(hydroxymethyl)nicotinamide  0   Niacinamide/*analogs & derivatives. Pharmacol Rep. 2006 Mar-Apr;58(2):246-9
nicomide  0   *Zinc Drug Combinations Niacinamide/*analogs & derivatives. Cutis 2006 Jan;77(1 Suppl):5-10
N-(4-pyridyl)isonicotinamide  0   Niacinamide/*analogs & derivatives. Langmuir. 2004 Nov 23;20(24):10413-8
S(2) complex  0   *Ascorbic Acid *Copper *Niacinamide. Exp Parasitol 2006 Feb;112(2):85-91
cytoflavin  0   *Flavin Mononucleotide *Inosine Diphosphate *Niacinamide *Succinates Drug Combinations. Biull Eksp Biol Med 2000 Feb;129(2):149-51
6-(4-((3-fluorobenzyl)oxy)phenoxy)nicotinamide  0   Niacinamide/*analogs & derivatives. Bioorg Med Chem. 2005 Feb 1;13(3):717-24
2-(7-(3,4-dimethoxyphenyl)imidazo(1,2-c)pyrimidin-5-ylamino)nicotinamide  0   *Pyrimidines Niacinamide/*analogs & derivatives. J Pharmacol Exp Ther 2003 Sep;306(3):1174-81
N-cyanomethyl-2-chloroisonicotinamide  0   Niacinamide/*analogs & derivatives. Plant Cell Physiol 2002 Jul;43(7):823-759-67
1-benzylnicotinamide  0   Niacinamide/*analogs & derivatives. Inorg Chem 2002 Feb 25;41(4):625-7
1-benzylnicotinamide triflate  0   Niacinamide/*analogs & derivatives. Inorg Chem 2001 Dec 17;40(26):6705
nicotinamide ribose-5'-methyl phosphate  0   Niacinamide/*analogs & derivatives Ribose/*analogs & derivatives. Inorg Chem 2001 Dec 17;40(26):6705
PFC-Kyoto solution  0   Fluorocarbons Glutamine Hetastarch Magnesium Sulfate Niacinamide Epoprostenol Trehalose. Transplant Proc 2000 Nov;32(7):1660-1
1-benzyl-1,4-dihydronicotinamide dimer  0   Niacinamide/*analogs & derivatives. Inorg Chem 2001 Mar 12;40(6):1213-9
CI 1044  0   *Azepines Niacinamide/*analogs & derivatives. J Med Chem 2000 Dec 14;43(25):4850-67
LY 362884  0   *Benzimidazoles Niacinamide/*analogs & derivatives. J Pharmacol Exp Ther 2000 Sep;294(3):923-32
1-(4'-(4''-acetamido-2''-sulphoanilino)-2'-sulphoanilino)-3-(3'-carboxamidopyridino)-2,4,6-sym-triazine-3-amine  0   Niacinamide/*analogs & derivatives Triazines Coenzymes. J Mol Recognit 1999 Jan-Feb;12(1):45-56
T 86  0   *Organometallic Compounds Niacinamide/*analogs & derivatives Cobalt. Gig Sanit 1999 Sep-Oct;(5):31-3
nicotinamido-4-bis(2-chloroethyl)aminobenzaldimine  0   Niacinamide/*analogs & derivatives. J Inorg Biochem 1999 Apr;73(4):195-202
1,4-dihydro-N-methylnicotinamide  0   Niacinamide/*analogs & derivatives. Biochem Pharmacol 1999 Mar 15;57(6);681-4
hydrazino nicotinamide  0   *Hydrazines Niacinamide/*analogs & derivatives. J Nucl Med 1999 Jan;40(1):192-7
V 3703  0   *Chlorhexidine *Niacinamide Drug Combinations. J Vet Dent 1995 Sep;12(3):87-91
FR 146801  0   Niacinamide/*analogs & derivatives. J Cardiovasc Pharmacol 1997 Aug;30(2):223-8
2-((2,4-dimethoxybenzyl)sulfinyl)-N-(4-pyridyl)nicotinamide  0   Niacinamide/*analogs & derivatives Sodium-Potassium-Exchanging ATPase/antagonists & inhibitors. J Med Chem 1997 Jan 31;40(3):313-21
N,N'-hexamethylenebis(3-pyridinecarboxamide)  73041-73-3   Niacinamide/*analogs & derivatives. Acta Crystallogr C 1996 Sep 15;52( Pt 9):2260-61
6-methylnicotinamide  6960-22-1   Niacinamide/*analogs & derivatives. Biochem Soc Trans 1996 Feb;24(1):61S
L 735286  0   Niacinamide/*analogs & derivatives Iodine Radioisotopes. Life Sci 1995 Jan 13;56(8):629-35
1,4-dimethylnicotinamide  126077-63-2   Niacinamide/*analogs & derivatives. Biol Pharm Bull 1993 Mar;16(3):304-6
CD 832  0   Niacinamide/*analogs & derivatives Nifedipine/*analogs & derivatives. Cardiovasc Drugs Ther 1993 Apr;7(2):265-71
menadione nicotinamide bisulfite  73581-79-0   Niacinamide/*analogs & derivatives Vitamin K 3/*analogs & derivatives. J Nutr 1993 Apr;123(4):737-43
succinimidyl 6-hydrazinonicotinate  133081-27-3   *Succinimides Niacinamide/*analogs & derivatives. Bioconjug Chem 1991 Sep-Oct;2(5):333-6
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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