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Epoprostenol

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Definition: A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from PROSTAGLANDIN ENDOPEROXIDES in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension (HYPERTENSION, PULMONARY).  /chem syn permitted: do not convert to PROSTAGLANDINS, SYNTHETIC; DF: PGX   
Pharmacological Action Antihypertensive Agents; Platelet Aggregation Inhibitors 		Other names Prostaglandin I2; Prostacyclin; PGX; PGI2; Prostaglandin I(2); Epoprostenol Sodium Salt, (5Z,9alpha,11alpha,13E,1; Epoprostenol Sodium; Epoprostanol; FlolanDrugs* : EPOPROSTENOL SODIUM; FLOLAN
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
carbaprostacyclin  0   Epoprostenol/*analogs & derivatives. Dtsch Med Wochenschr 1984 Sep 21;109(38):1433-8
3-oxacarbacyclin  0   Epoprostenol/*analogs & derivatives. J Org Chem. 2006 Jun 9;71(12):4642-50
dehydro-15-cyclohexylcarbaprostacyclin  0   *Epoprostenol. Am J Physiol Lung Cell Mol Physiol 2002 Aug;283(2):L428-32
13,14-dinor-inter-p-phenylene carbacyclin  0   Epoprostenol/*analogs & derivatives. J Am Chem Soc 2002 Apr 24;124(16):4321-8
15-deoxy-(16-m-tolyl)-17,18,19,20-tetranorisocarbacyclin methylester  0   Epoprostenol/*analogs & derivatives. Brain Res 2002 Jan 25;925(2):176-82
PFC-Kyoto solution  0   Fluorocarbons Glutamine Hetastarch Magnesium Sulfate Niacinamide Epoprostenol Trehalose. Transplant Proc 2000 Nov;32(7):1660-1
treprostinil  0   Epoprostenol/*analogs & derivatives.
Pharma Action Antihypertensive Agents 		Vasc Med 2000;5(4):231-7REMODULIN; TYVASO
15-deoxy-16-m-tolyl-17,18,19,20-tetranorisocarbacyclin  0   Epoprostenol/*analogs & derivatives. Biochem Biophys Res Commun 1999 Nov 19;265(2):301-4
16-tolyl-17,18,19,20-tetranorisocarbacyclin  0   Epoprostenol/*analogs & derivatives. J Neurochem 1999 Jun;72(6):2583-92
benzodioxane prostacyclin  0   Epoprostenol/*analogs & derivatives. J Cardiovasc Pharmacol 1997 Apr;29(4):525-35
AFP 07  0   Epoprostenol/*analogs & derivatives. Prostaglandins 1997 Feb;53(2):83-90
AFP 06  0   Epoprostenol/*analogs & derivatives. Prostaglandins 1997 Feb;53(2):83-90
AFP 03  0   Epoprostenol/*analogs & derivatives. Prostaglandins 1997 Feb;53(2):83-90
TEI 4343  0   Epoprostenol/*analogs & derivatives Receptors, Prostaglandin E/agonists. Biochem J 1997 Mar 1;322(Pt 2):597-601
tilsuprost  80225-28-1   Epoprostenol/*analogs & derivatives. Life Sci 1996;59(16):1297-306
TFC 132  0   Epoprostenol/*analogs & derivatives. Prostaglandins Leukot Essent Fatty Acids 1994 Oct;51(4):245
SM 10906  0   Epoprostenol/*analogs & derivatives. Biol Pharm Bull 1994 Jan;17(1):74-7
SM 10902  139403-31-9 Acetic acid, (2-(octahydro-5-hydroxy-4-(3-hydroxy-5-methyl-1-nonenyl)-2-pentalenyl)ethoxy)-, methyl ester, (2R-(2alpha,3aalpha,4alpha(1E,3S*,5S*),5beta,6aalpha))  Epoprostenol/*analogs & derivatives. Biol Pharm Bull 1994 Jan;17(1):74-7
Osaka University cocktail  0   Epoprostenol/analogs & derivatives Verapamil Organ Preservation Solutions. Transplant Proc 1993 Dec;25(6):3093-4
MM 706  149639-79-2   Epoprostenol/*analogs & derivatives. Eksp Klin Farmakol 1992 Sep-Oct;55(5):36-9
19-(3-azidophenyl)-20-norisocarbacyclin  140900-65-8   *Azides Epoprostenol/*analogs & derivatives. J Biol Chem 1992 Oct 5;267(28):20326-30
TEI 1324  106396-38-7 2-Pentalenepentanoic acid, 1,3a,4,5,6,6a-hexahydro-5-hydroxy-6-(3-hydroxy-5-methyl-1-nonenyl)-, methyl ester, (3aS-(3aalpha,5beta,6alpha(1E,3R*,5R*),6aalpha))  Epoprostenol/*analogs & derivatives. Prostaglandins Leukot Essent Fatty Acids 1991 Dec 44(4):237-9
TEI 3356  133906-74-8 2-Pentalenepentanoic acid, 1,3a,4,5,6,6a-hexahydro-5-hydroxy-6-(4-hydroxy-4-methyl-1-octenyl)-, (3aS-(3aalpha,5beta,6alpha(1E,4R*),6aalpha))  Epoprostenol/*analogs & derivatives Receptors, Prostaglandin E/agonists. Prostaglandins Leukot Essent Fatty Acids 1991 Dec;44(4):237-9
TY 11223  140694-43-5   Epoprostenol/*analogs & derivatives. Chem Pharm Bull (Tokyo) 1992 Jan;40(1):279-81
TRY 200  136626-78-3 TRY 200  Epoprostenol/*analogs & derivatives. J Clin Gastroenterol 1991;13 Suppl 1:S54
TTC 909  0   Epoprostenol/*analogs & derivatives. Acta Neurochir Suppl (Wien) 1990;51:242
KP 10614  130273-99-3   Epoprostenol/*analogs & derivatives. J Pharmacol Exp Ther 1990;255(3):1210
4,5-didehydroisocarbacyclin  98676-80-3   Epoprostenol/*analogs & derivatives. Chem Pharm Bull (Tokyo) 1990;38(6):1769
TY 10957  117028-28-1 Acetic acid, (2-(2,3,3a,6,7,7a-hexahydro-2-hydroxy-1-(3-hydroxy-4-methyl-4-phenoxy-1-pentenyl)-1H-inden-5-yl)ethoxy)-, (1alpha(1E,3R*),2beta,3aalpha,7aalpha)  Epoprostenol/*analogs & derivatives. Digestion 1990;45(2):61
bicyclo(4.3.0)non-2-ene homoisocarbacyclin  0   Epoprostenol/*analogs & derivatives. Chem Pharm Bull (Tokyo) 1989;37(6):1647
3-oxahomoisocarbacyclin  127127-92-8   Epoprostenol/*analogs & derivatives. Chem Pharm Bull (Tokyo) 1989;37(6):1647
homoisocarbacyclin  130377-59-2   Epoprostenol/*analogs & derivatives. Chem Pharm Bull (Tokyo) 1989;37(6):1647
CL 115999  122744-25-6 Prost-13-en-1-oic acid, 6,9-epoxy-16-ethenyl-11,16-dihydroxy-5-iodo-, methyl ester, (9alpha,11alpha,13E)  Epoprostenol/*analogs & derivatives. Adv Prostaglandin Thromboxane Leukotriene Res 1989;19:331
Chinoin 7384  119330-63-1 Chinoin 7384  Epoprostenol/*analogs & derivatives. Biomed Biochim Acta 1988;47(10-11):S113
Chinoin 7284  119330-62-0 Chinoin 7284  Epoprostenol/*analogs & derivatives. Biomed Biochim Acta 1988;47(10-11):S113
15-fluoro-13,14-dehydrocarbacyclin  120593-19-3   Epoprostenol/*analogs & derivatives Prostaglandins, Synthetic. Bioorg Khim 1988;14(6):834
17,20-dimethylisocarbacyclin  122168-74-5   Epoprostenol/*analogs & derivatives Prostaglandins, Synthetic. Transplantation 1988;46(4):626
CG 4303  109010-68-6   Epoprostenol/*analogs & derivatives Prostaglandins, Synthetic. Biol Chem Hoppe Seyler 1988;369(5):329
dihomo-prostaglandin I(2)  99286-22-3   Epoprostenol/*analogs & derivatives. Biochim Biophys Acta 1988;958(3):460
7-oxo-cyclopentyl-prostaglandin I2  111319-88-1 Pentanoic acid, 5-(hexahydro-5-hydroxy-6-(3-hydroxy-1-octenyl)-1-oxo-2(1H)-pentalenylidene)-, (3aS-(2Z,3aalpha,5beta,6alpha(1E,3R*),6aalpha))  Epoprostenol/*analogs & derivatives. Prog Clin Biol Res 1987;242:113
15-cyclopentyl-7-oxo-prostaglandin I2-ephedrine  100992-40-3   Ephedrine/*analogs & derivatives Epoprostenol/*analogs & derivatives. Thromb Res 1987;47(1):117
7-oxo-prostaglandin I2-ephedrine  108590-75-6   Ephedrine/*analogs & derivatives Epoprostenol/*analogs & derivatives. Thromb Res 1987;47(1):117
3-oxa-9(O)-methano-delta(6,9)prostaglandin I(1)  106402-09-9   Epoprostenol/*analogs & derivatives. Chem Pharm Bull (Tokyo) 1987;35(3):948
2,2,10,10-tetrafluoro-13-dehydroprostacyclin  118916-24-8   Epoprostenol/*analogs & derivatives. Adv Prostaglandin Thromboxane Leukotriene Res 1987;17B:775
TEI 9090  88931-51-5 2-Pentalenepentanoic acid, 1,3a,4,5,6,6a-hexahydro-5-hydroxy-6-(3-hydroxy-1-octenyl)-, methyl ester, (3aS-(3aalpha,5beta,6alpha(1E,3R*),6aalpha))  Epoprostenol/*analogs & derivatives Prostaglandins, Synthetic. Prostaglandins 1987;33(2):161
5-methyleneisocarbacyclin  109838-17-7   Epoprostenol/*analogs & derivatives Prostaglandins, Synthetic. Chem Pharm Bull (Tokyo) 1986;34(10):4403
U 72382  101691-66-1   Epoprostenol/*analogs & derivatives. Prostaglandins 1986;32(5):647
OP 41483-alpha-cyclodextrin  108866-14-4   *alpha-Cyclodextrins Epoprostenol/*analogs & derivatives Prostaglandins, Synthetic. Transplant Proc 1987;19(1 Pt 3):2115
naxaprostene  89955-40-8   Epoprostenol/*analogs & derivatives Prostaglandins, Synthetic. Arzneimittelforschung 1986;36(8):1180
RS 93427-007  105284-21-7   *Bridged Compounds Epoprostenol Prostaglandins, Synthetic. Lancet 1986;2(8508):682
OP 2507  72520-05-9   Epoprostenol/*analogs & derivatives. Eur J Pharmacol 1986;123(3):335
SC 39902  101641-82-1 Prosta-6,13-dien-1-oic acid, 6,9-epoxy-5-fluoro-11,15-dihydroxy-, monosodium salt, (5S,9alpha,11alpha,13E,15S)  Epoprostenol/*analogs & derivatives. Drugs Exp Clin Res 1986;12(5):371
beraprost  88430-50-6 1H-Cyclopenta(b)benzofuran-5-butanoic acid, 2,3,3a,8b-tetrahydro-2-hydroxy-1-(3-hydroxy-4-methyl-1-octen-6-ynyl)-, monosodium salt  Epoprostenol/*analogs & derivatives Cryoprotective Agents.
Pharma Action Platelet Aggregation Inhibitors ; Vasodilator Agents 		Arzneimittelforschung 1985;35(12):1816
U 68215  99464-90-1   Epoprostenol/*analogs & derivatives. Prostaglandins 1985;30(4):619
6a-carbaprostaglandin I3  96244-85-8   Epoprostenol/*analogs & derivatives Prostaglandins, Synthetic. Chem Pharm Bull (Tokyo) 1984;32(12):4746
ciprostene  81845-44-5 Pentanoic acid, 5-(hexahydro-5-hydroxy-6-(3-hydroxy-1-octenyl)-3a-methyl-2(1H)-pentalenylidene)-, (3aS-(2Z,3aalpha,5beta,6alpha(1E,3R*),6aalpha))  Epoprostenol/*analogs & derivatives Prostaglandins, Synthetic. J Chromatogr 1985;321(1):209
5-nitroprostaglandin I2  86022-39-1   Epoprostenol/*analogs & derivatives. Adv Myocardiol 1985;6:607
20-methyl-13,14-didehydro-2,4-inter-3-phenylene prostaglandin I2  96744-62-6   Epoprostenol/*analogs & derivatives Prostaglandins, Synthetic. Exp Mol Pathol 1985:42(2):163
7a-homo-2-norprostacyclin  100307-96-8 Prosta-4,13-dien-1-oic acid, 5,9-epoxy-11,15-dihydroxy-, (4Z,9alpha,11alpha,13E,15S)  Epoprostenol/*analogs & derivatives. Med Res Rev 1985;5(1):1
APS 306  90880-59-4   Epoprostenol/*analogs & derivatives Prostaglandins, Synthetic. Trans Am Soc Artif Intern Organs 1984;30:44
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