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Fluorine Radioisotopes

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Definition: Unstable isotopes of fluorine that decay or disintegrate emitting radiation. F atoms with atomic weights 17, 18, and 20-22 are radioactive fluorine isotopes.  F-17, 18, 20-22; /blood-csf-urine /metab permitted but not for tracer studies (    Other names Radioisotopes, FluorineDrugs* : FLUORINE F-18; SODIUM FLUORIDE F 18
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
GE-180  0   *Carbazoles Fluorine Radioisotopes. Bioorg Med Chem Lett. 2012 Feb 1;22(3):1308-13.
1-O-(4-(2-fluoroethylcarbamoyloxymethyl)-2-nitrophenyl)-O-glucopyronuronate  0   *Glucuronates Fluorine Radioisotopes. J Nucl Med. 2012 Mar;53(3):451-8.
(18F)azadibenzocyclooctyne  0   *Aza Compounds *Cyclooctanes Fluorine Radioisotopes. Bioorg Med Chem Lett. 2011 Dec 1;21(23):6987-91
(18)F-ICMT11  0   *Azides *Indoles Fluorine Radioisotopes. Bioorg Med Chem Lett. 2011 Dec 1;21(23):6945-9
3-(2-azetidinylmethoxy)-5-(3'-fluoropropyl)pyridine  0   *Azetidines *Pyridines Fluorine Radioisotopes Nicotinic Antagonists. Nucl Med Biol. 2011 Nov;38(8):1183-92.
1-(2'-deoxy-2'-fluoro-arabinofuranosyl)cytosine  0   Cytarabine/*analogs & derivatives Fluorine Radioisotopes. J Nucl Med. 2012 Feb;53(2):275-80.
2-(6-fluoro-2,3'-bipyridin-5'-yl)-7-methyl-7-azabicyclo(2.2.1)heptane  0   *Azabicyclo Compounds 2,2'-Dipyridyl/*analogs & derivatives Fluorine Radioisotopes Ligands. J Nucl Med. 2012 Jan;53(1):106-12.
N-2-(4-fluorobenzamido)ethylmaleimide-EM 3106B  0   *Maleimides Glucagon-Like Peptide 1/*analogs & derivatives Fluorine Radioisotopes. Mol Pharm. 2011 Oct 3;8(5):1775-82.
4-fluoroglutamine  0   Glutamine/*analogs & derivatives Fluorine Radioisotopes. J Nucl Med. 2011 Dec;52(12):1947-55.
N-(1-fluoro-3-phenylpropan-2-yl)-N-methylprop-2-yn-1-amine  0   Selegiline/*analogs & derivatives Fluorine Radioisotopes Monoamine Oxidase Inhibitors. J Med Chem. 2011 Oct 27;54(20):7023-9.
7-(3-(4-(2-fluoroethoxy)phenyl)propyl)-2-(furan-2-yl)-7H-pyrazolo(4,3-e)(1,2,4)triazolo(1,5-c)pyrimidin-5-amine  0   *Pyrazoles *Pyrimidines Fluorine Radioisotopes. Nucl Med Biol. 2011 Aug;38(6):897-906.
2-deoxy-2-fluoroacetamidoglucopyranose  0   Acetylglucosamine/*analogs & derivatives Fluorine Radioisotopes. Nucl Med Biol. 2011 Aug;38(6):807-17.
N-(6-fluoro-4-phenoxypyridin-3-yl)-N-(2-methoxybenzyl)acetamide  0   *Acetamides *Aminopyridines Fluorine Radioisotopes. Bioorg Med Chem Lett. 2011 Aug 15;21(16):4819-22.
NS 10743  0   *Oxadiazoles *Azabicyclo Compounds Fluorine Radioisotopes. Eur J Nucl Med Mol Imaging 2011 Aug;38(8):1541-9
N1-(4-(2-fluoroethyl)phenyl)-N8-hydroxyoctanediamide  0   *Anilides *Hydroxamic Acids Fluorine Radioisotopes. Nucl Med Biol 2011 Jul;38(5):683-96
N-(3-bromo-4-(3-(18F)fluoro-propoxy)benzyl)guanidine  0   *Fluorobenzenes *Guanidines Fluorine Radioisotopes Radiopharmaceuticals. Circ Cardiovasc Imaging. 2011 Jul;4(4):435-43
ethyl galactopyranosyl-(1-4)-2'-deoxy-2'-fluoroglucopyranoside  0   *Disaccharides Fluorine Radioisotopes Ligands. Mol Imaging Biol 2011 Jun;13(3):536-46
4-fluoro-N-(4-(6-(isopropylamino)pyrimidin-4-yl)-1,3-thiazol-2-yl)-N-methylbenzamide  0   *Benzamides *Thiazoles Fluorine Radioisotopes. Bioorg Med Chem Lett 2011 May 15;21(10):2998-3001
4-fluorobenzoyl-phenylalanyl-alanyl-leucyl-glycyl-glutamyl-alaninamide  0   *Oligopeptides Fluorine Radioisotopes. Nucl Med Biol 2011 May;38(4):509-15
S-(3-fluoropropyl)homocysteine  0   Homocysteine/*analogs & derivatives Fluorine Radioisotopes. J Med Chem 2011 Mar 24;54(6):1860-70
1-(2'-deoxy-2'-fluoro-1-arabinofuranosyl)-5-uracil  0   Arabinofuranosyluracil/*analogs & derivatives Fluorine Radioisotopes. Eur J Nucl Med Mol Imaging 2009 Dec;36(12):1987-93
2-amino-3-(1-(2-fluoroethyl)-1H-(1,2,3)triazol-4-yl)propanoic acid  0   *Triazoles Alanine/*analogs & derivatives Fluorine Radioisotopes. Mol Imaging 2010 Dec;9(6):329-42
N-(4-fluorobenzoyl)-N'-(2-(5-(4-fluorobenzyl)-1-(4-methoxybenzyl)-4,6-dioxo-1,4,5,6-tetrahydro(1,3,5)triazin-2-ylamino)ethyl)guanidine  0   *Guanidines *Triazines Fluorine Radioisotopes. J Nucl Med 2011 Apr;52(4):600-7
1'-benzyl-3-(2-fluoroethyl)-3H-spiro((2)benzofuran-1,4'-piperidine)  0   *Piperidines *Benzofurans Fluorine Radioisotopes Ligands. Eur J Nucl Med Mol Imaging 2011 Mar;38(3):540-51
6-(1-(2-fluoro-3-pyridyl)-5-methyl-1H-1,2,3-triazol-4-yl)quinoline  0   *Quinolines *Triazoles Fluorine Radioisotopes. Bioorg Med Chem 2011 Jan 1;19(1):102-10
BAY 86-4367  0   Bombesin/*analogs & derivatives Fluorine Radioisotopes. J Nucl Med 2011 Feb;52(2):270-8
5-fluoro-3-(4-phenylpiperidin-1-yl)-1,2,3,4-tetrahydronaphthalen-2-ol  0   *Naphthols *Piperidines Fluorine Radioisotopes. Bioorg Med Chem 2010 Nov 1;18(21):7659-67
methyl-8-((2-(fluoromethyl)cyclopropyl)methyl)-3-phenyl-8-azabicyclo(3.2.1)octane-2-carboxylate  0   Cocaine/*analogs & derivatives Fluorine Radioisotopes. ChemMedChem 2010 Oct 4;5(10):1686-8
methyl-4-fluoro-4-deoxyglucose  0   *Glucosides Fluorine Radioisotopes. Am J Physiol Cell Physiol 2010 Dec;299(6):C1277-84
4-fluoro-4-deoxyglucose  0   Deoxyglucose/*analogs & derivatives Fluorine Radioisotopes. Am J Physiol Cell Physiol 2010 Dec;299(6):C1277-84
5-((3-fluoromethoxy)phenyl)-3-(1-phenylethylamino)-1-(4-trifluoromethylphenyl)pyrrolidin-2-one  0   *Pyrrolidinones Fluorine Radioisotopes Ligands. Eur J Nucl Med Mol Imaging 2010 Aug;37(8):1499-506
3-fluoro-2-(4-((2-nitro-1H-imidazol-1-yl)methyl)-1H-1,2,3-triazol-1-yl)propan-1-ol  0   *Nitroimidazoles *Triazoles Fluorine Radioisotopes. Eur J Nucl Med Mol Imag 2010 Aug;37(9):1663-8
1-(2,4-difluorophenethyl)-4-(4-fluorophenylsulfinyl)piperidine  0   *Piperidines *Sulfoxides Fluorine Radioisotopes Receptor, Serotonin, 5-HT2A. Nucl Med Biol 2010 Jul;37(5):605-14
1-(2,4-difluorophenethyl)-4-(4-fluorophenylsulfonyl)piperidine  0   *Piperidines *Sulfones Fluorine Radioisotopes Receptor, Serotonin, 5-HT2A. Nucl Med Biol 2010 Jul;37(5):605-14
1-amino-2-fluorocyclopentyl-1-carboxylic acid  0   Cycloleucine/*analogs & derivatives Fluorine Radioisotopes. J Med Chem 2010 Sep 23;53(18):6603-7
5-fluoro-6-((2-iminopyrrolidin-1-yl)methyl)uracil  0   *Pyrrolidines Uracil/*analogs & derivatives Fluorine Radioisotopes Thymidine Phosphorylase/antagonists & inhibitors. Nucleosides Nucleotides Nucleic Acids 2010 Jan;29(1):49-54
N-(4-fluorobut-2-en-1-yl)-2-carbomethoxy-3-(4'-fluorophenyl)nortropane  0   *Nortropanes Fluorine Radioisotopes. J Med Chem 2010 Aug 12;53(15):5549-57
18-fluoro-4-thiaoleic acid  0   *Oleic Acids *Sulfides Fluorine Radioisotopes. J Nucl Med 2010 Aug;51(8):1310-7
9-fluoroethyldihydrotetrabenazine  0   Tetrabenazine/*analogs & derivatives Fluorine Radioisotopes. Nucl Med Biol 2010 Apr;37(3):357-63
6-methyl-2-(4'-fluorophenyl)-1,3-benzothiazole  0   *Benzothiazoles Fluorine Radioisotopes. J Med Chem 2009 Mar 12;52(5):1428-37
2-hydroxy-3-(4-(4-fluorobenzoyl)piperidino)tetralin  0   *Piperidines *Tetrahydronaphthalenes Fluorine Radioisotopes. J Med Chem 2009 Mar 12;52(5):1358-69
2-(4'-(methylamino)phenyl)-6-(2-fluoroethoxy)benzothiazole  0   *Benzothiazoles Fluorine Radioisotopes. Appl Radiat Isot 2010 Jun;68(6):1066-72
3-(pyridin-2-ylethynyl)cyclohex-2-enone-O-2-(2-fluoroethoxy)ethyloxime  0   *Oximes *Pyridines Fluorine Radioisotopes Ligands. J Med Chem 2010 May 27;53(10):4009-17
9-fluoropropyldihydrotetrabenazine  0   Tetrabenazine/*analogs & derivatives Fluorine Radioisotopes. Nucl Med Biol 2010 Feb;37(2):133-41
O-galactopyranosyl-(1-4')-2'-deoxy-2'-fluoroethylglucopyranose  0   Lactose/*analogs & derivatives Fluorine Radioisotopes. PLoS One 2009;4(11):e7977
6-fluoronicotinic acid 2,3,5,6-tetrafluorophenyl ester  0   *Nicotinic Acids Fluorine Radioisotopes. J Med Chem 2010 Feb 25;53(4):1732-40
5-(2-fluoroethoxy)tryptophan  0   Tryptophan/*analogs & derivatives Fluorine Radioisotopes. Appl Radiat Isot 2010 Feb;68(2):303-8
5-(fluoromethoxy)-N-methyl-3-oxo-N-(2-piperidin-1-ylethyl)-3H-spiro(2-benzofuran-1,1'-cyclohexane)-4'-carboxamide  0   *Benzofurans *Piperidines Deuterium Fluorine Radioisotopes Receptors, Histamine H3. Synapse 2009 Dec;63(121):1122-32
3-(4'-fluorobenzylidene)indolin-2-one  0   *Indoles Fluorine Radioisotopes. Bioorg Med Chem 2009 Nov 15;17(22):7732-42
18-fluoro-17-estradiol  0   Estradiol/*analogs & derivatives Fluorine Radioisotopes. Bull Cancer 2009 Nov;96(11):1053-70
4-(2-(6-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)-N-methylbenzamide  0   *Aniline Compounds *Ethylene Glycols Fluorine Radioisotopes. J Nucl Med 2009 Nov;50(11):1887-94AMYVID
3-((6-Fluoropyridin-2-yl)ethynyl)cyclohex-2-enone O-methyl oxime  0   *Oximes *Pyridines Fluorine Radioisotopes. Nucl Med Biol 2009 Aug;36(6):613-22
2-18F-fluoropropionic acid  0   *Fluorocarbons Fluorine Radioisotopes. J Nucl Med. 2009 Oct;50(10):1709-14
N-(2-(diethylamino)ethyl)-6-fluoronicotinamide  0   Niacinamide/*analogs & derivatives Fluorine Radioisotopes. J Med Chem 2009 Sep 10;52(17):5299-302
17-(4-(2-fluoroethyl)-1H-1,2,3-triazol-1-yl)-6-thia-heptadecanoic Acid  0   *Fatty Acids *Triazoles Fluorine Radioisotopes. Bioconjug Chem 2009 Jun;20(6):1139-45
6-(fluoroacetamido)-1-hexanoicanilide  0   *Anilides Fluorine Radioisotopes. Nucl Med Biol 2009 Apr;36(3):247-58
N-(4-fluorobenzyl)-4-(3-(piperidin-1-yl)indole-1-sulfonyl)benzamide  0   *Benzamides *Indoles *Piperidines Carbon Radioisotopes Fluorine Radioisotopes. Synapse. 2009 Jan;63(1):22-30
1-(3-(2-fluoropyridin-3-yloxy)propyl)pyrrole-2,5-dione  0   *Pyridines *Succinimides Fluorine Radioisotopes. Adv Exp Med Biol 2009;611:405-6
6-(2-fluoropropyl)-4-methylpyridin-2-amine  0   *Aminopyridines Fluorine Radioisotopes Nitric Oxide Synthase Type II/antagonists & inhibitors. J Med Chem 2009 Apr 23;52(8):2443-53
4-fluorobenzaldehyde-O-(2-(2-(2-(pyrrol-2,5-dione-1-yl)ethoxy)ethoxy)ethyl)oxime  0   *Maleimides *Oximes Fluorine Radioisotopes. Amino Acids 2009 Feb;36(2):283-95
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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