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Ligands

More information in Books or onNLM PubMed
Definition: A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)  IM for general only; usually NIM with specific cpd IM; no qualif   
See Also Radioligand Assay; Receptors, Cell Surface
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
6-(4-nitrobenzyl)-1-oxa-4,7,10-triazacyclododecane-N,N'',N'''-triacetic acid  0   *Acetic Acids *Heterocyclic Compounds, 1-Ring Ligands. Bioorg Med Chem. 2012 Jan 15;20(2):978-84.
1-oxa-4,7,10-triazacyclododecane-N,N'',N'''-triacetic acid  0   *Acetic Acids *Heterocyclic Compounds, 1-Ring Ligands. Bioorg Med Chem. 2012 Jan 15;20(2):978-84.
20-oxo-5-pregnan-3-yl-glutamyl 1-ester  0   *Glutamates Pregnanolone/*analogs & derivatives Ligands. Neuropharmacology. 2011 Jul-Aug;61(1-2):61-8.
Sysu-00692  0   Berberine/*analogs & derivatives Ligands. Biochem Biophys Res Commun. 2012 Mar 16;419(3):567-72.
1-pentanoyl-N-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)pyrrolidine-2-carboxamide  0   Losartan/*analogs & derivatives Ligands Receptor, Angiotensin, Type 1. ChemMedChem. 2007 Sep;2(9):1298-310.
tetrabi  0   *Biphenyl Compounds *Organophosphorus Compounds Ligands. Chemistry. 2011 Dec 16;17(51):14559-63
cholecystokinin (26-32) phenylethyl ester, tyrosyl-glycyl-(norleucyl(28.31)-tryptophyl(30))  0   *Peptide Fragments Cholecystokinin/*analogs & derivatives Ligands. Am J Physiol Cell Physiol. 2012 Feb;302(3):C615-27.
ligand of Numb protein X2, human  0   *Carrier Proteins Ligands. J Cell Sci. 2011 Nov 1;124(Pt 21):3545-56.
urotensin II-related peptide, 2-amino-3-(1,1'-bipheny-4-yl)propanoic acid(4)  0   *Peptide Hormones Ligands. Biochem Pharmacol. 2012 Mar 1;83(5):608-15.
1-(4-benzylpiperidin-1-yl)-2-(6-hydroxy-1H-indol-3-yl)ethane-1,2-dione  0   *Indoles *Piperidines Ligands. J Med Chem. 2011 Dec 22;54(24):8702-6.
2-(4-benzylpiperidin-1-yl)-1-(6-hydroxy-1H-indol-3-yl)ethanone  0   *Indoles *Piperidines Ligands. J Med Chem. 2011 Dec 22;54(24):8702-6.
1-(2,3-dihydrobenzo(b)(1,4)dioxin-6-yl)-4-((6-fluoropyridin-3-yl)methyl)piperazine  0   *Dioxanes *Piperazines Ligands Receptors, Dopamine D4. J Med Chem. 2011 Dec 22;54(24):8343-52.
1,3-dihydroxypropan-2-yl 11-(3-hydroxy-5-(2-methyloctan-2-yl)phenoxy)undecanoate  0   *Monoglycerides Ligands Receptor, Cannabinoid, CB1. J Med Chem. 2011 Dec 22;54(24):8278-88.
1,3-dihydroxypropan-2-yl 11-(2-hexyl-5-hydroxyphenoxy)undecanoate  0   *Phenols *Monoglycerides Ligands Receptor, Cannabinoid, CB1. J Med Chem. 2011 Dec 22;54(24):8278-88.
4'-(4-(4,5-diphenyl-1H-imidazol-2-yl)phenyl)-(2,2'-6',2'')terpyridine  0   *Imidazoles *Pyridines Ligands. Dalton Trans. 2011 Nov 28;40(44):11795-808.
3-(2-nitrophenyl)-1H-1,2,4-triazole-5(4H)-thione  0   *Thiones *Triazoles Ligands. J Agric Food Chem. 2011 Oct 26;59(20):11352-8.
2-(6-fluoro-2,3'-bipyridin-5'-yl)-7-methyl-7-azabicyclo(2.2.1)heptane  0   *Azabicyclo Compounds 2,2'-Dipyridyl/*analogs & derivatives Fluorine Radioisotopes Ligands. J Nucl Med. 2012 Jan;53(1):106-12.
Nalpha-(2,2-diphenylacetyl)-N-(4-hydroxybenzyl)-Nomega-(4-propanoylaminobutyl)aminocarbonylargininamide  0   *Diphenylacetic Acids Arginine/*analogs & derivatives Ligands Tritium. ChemMedChem. 2011 Sep 5;6(9):1566-71.
N-(2-(triphenylmethyl)thioethyl)-3-aza-19-ethyloxycarbonyl-3-(2-(triphenylmethyl)thioethyl)octadecanoate  0   *Palmitic Acids Glycine/*analogs & derivatives Ligands. Nucl Med Biol. 2011 Oct;38(7):1043-52.
N,N'-bis(1-naphthaldimine)-o-phenylenediamine  0   *Imines *Phenylenediamines Ligands. Spectrochim Acta A Mol Biomol Spectrosc. 2011 Oct 15;81(1):570-7.
pentafluorophenyldipyrrinphenol  0   *Phenols *Pyrroles Ligands. Dalton Trans. 2011 Sep 28;40(36):9090-3
N-(3-hydroxy-1-(naphthalen-1-yl)-1,8,11-trioxa-5-azatridecan-13-yl)-6-(2-(2-(4,4-difluoro-4,4a-dihydro-5-(thiophen-2-yl)-4-bora-3a,4a-diaza-s-indacene-3-yl)vinyl)phenoxyacetamido)hexanamide  0   *Boron Compounds Fluorescent Dyes Ligands. J Med Chem. 2011 Oct 13;54(19):6874-87.
CG14871 protein, Drosophila  0   *Carrier Proteins *Drosophila Proteins Ligands. Biochem Biophys Res Commun. 2011 Oct 14;414(1):44-8.
3-(2'-fluoro-6',7'-dihydrospiro(piperidine-4,4'-thieno(3,2-c)pyran)-1-yl)-2-(2-fluorobenzyl)-N-methylpropanamide  0   *Spiro Compounds *Bicyclo Compounds, Heterocyclic Carbon Radioisotopes Ligands. J Nucl Med 2011 Oct;52(10):1638-45
pyridostatin  0   *Aminoquinolines *Picolinic Acids Ligands. Nat Chem 2011 Oct;3(10):782-7
N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide  0   *Aminoquinolines *Picolinic Acids Ligands. Nat Chem 2011 Oct;3(10):782-7
N1-benzenesulfonyl-3-(4-chloro-1-methyl-2,5-dihydro-1H-pyrrol-3-yl)-1H-indole  0   *Indoles *Sulfonamides Ligands. Bioorg Med Chem Lett 2011 Aug 1;21(15):4577-80
N,N-di-n-propyl-(N1-methyl-2-(4'-nitrophenyl)indol-3-yl)glyoxylamide  0   *Amides *Indoles Ligands. J Med Chem 2011 Jan 13;54(1):366-73
4-(5-(1-methyl-1H-pyrrol-2-yl)-1,3,4-oxadiazol-2-yl)-1,4-diazabicyclo(3.2.2)nonane  0   *Oxadiazoles *Azabicyclo Compounds Carbon Radioisotopes Ligands. J Nucl Med 2011 Sep;52(9):1449-56
GSK 931145  0   *Benzamides Ligands. Brain Res 2010 May 17;1331:105-13
(4-(dimethylamino)phenyl)(5-iodobenzofuran-2-yl)methanone  0   *Aniline Compounds *Benzofurans Ligands. Bioorg Med Chem 2011 Jul 1;19(13):4148-53
(4,7-bis-carboxymethyl-10-(1-(2-(5-(2-oxohexahydrothieno(3,4-d)imidazol-6-yl)-pentanoylamino)ethyl)-1H-(1,2,3)triazol-4-ylmethyl)-1,4,7,10-tetraazacyclododec-1-yl)acetic acid  0   *Heterocyclic Compounds, 1-Ring Biotin/*analogs & derivatives Ligands. J Drug Target 2011 Jul;19(6):418-26
glucocorticoid-induced tumor necrosis factor receptor ligand, rat  0   *Carrier Proteins Ligands. Transplant Proc 2011 Jun;43(5):1971-5
N-(adamantan-1-yl)-8-methoxy-4-oxo-1-pentyl-1,4-dihydroquinoline-3-carboxamide  0   *Quinolones Adamantane/*analogs & derivatives Ligands Receptor, Cannabinoid, CB2. J Med Chem 2011 Aug 11;54(15):5444-53
N-(2-(2-ethyl-8,9-dihydrofuro(3,2-c)pyrazolo(1,5-a)pyridin-1-yl)ethyl)acetamide  0   *Heterocyclic Compounds, 3-Ring Ligands. J Med Chem 2011 Jun 23;54(12):4207-18
NIR-mbc94  0   *Norbornanes *Pyrazoles Ligands. Chem Biol 2011 May 27;18(5):563-8
methylterephthalamide  0   *Amides *Phthalic Acids Ligands. Chem Commun (Camb). 2011 Jun 14;47(22):6392-4
phenylpyridyldiazomethane  0   *Azo Compounds *Pyridines Ligands. Inorg Chem. 2011 Jun 6;50(11):5186-95
N,N',N',N-tetrakis((N-(arginyl-arginyl-prolyl-tyrosyl-isoleucyl-leucine)aminocarbonyl)ethyl)-1,4,8,11-tetraazacyclotetradecane  0   *Heterocyclic Compounds, 1-Ring *Peptide Fragments Neurotensin/*analogs & derivatives Ligands. J Inorg Biochem 2011 Jun;105(6):821-32
chemerin protein, rat  0   *Adipokines Ligands. Acta Pharmacol Sin 2011 May;32(5):573-80
ethyl galactopyranosyl-(1-4)-2'-deoxy-2'-fluoroglucopyranoside  0   *Disaccharides Fluorine Radioisotopes Ligands. Mol Imaging Biol 2011 Jun;13(3):536-46
folate-glutathione-polyethyleneglycol-distearoyl phosphatidylethanolamine  0   *Phosphatidylethanolamines Folic Acid/*analogs & derivatives Ligands. Anticancer Res 2011 May;31(5):1521-5
Pam2CSK4 lipopeptide  0   *Lipopeptides Ligands. Arthritis Rheum 2011 Jun;63(6):1527-33
2,2-bis(3,5-dimethylpyrazol-1-yl)propionate  0   *Propionates *Pyrazoles Ligands. Dalton Trans. 2011 May 7;40(17):4678-86
17-(4'-ethynyldimethylbenzylamine)-17-testosterone  0   Ethisterone/*analogs & derivatives Ligands. J Inorg Biochem 2011 Apr;105(4):525-31
9-benzyl-2-butoxy-8-hydroxyadenine  0   Adenine/*analogs & derivatives Ligands. J Immunol 2011 Apr 15;186(8):4707-15
11-(3-(4-((4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-1H-1,2,3-triazol-1-yl)propoxy)-N-propylnoraporphine  0   *Aporphines *Piperazines Ligands Receptors, Dopamine D3. Bioorg Med Chem 2011 Mar 15;19(6):1999-2008
11-((1-(3-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)-1H-1,2,3-triazol-4-yl)methoxy)-N-propylnoraporphine  0   *Aporphines *Piperazines Ligands Receptors, Dopamine D3. Bioorg Med Chem 2011 Mar 15;19(6):1999-2008
5-bromo-N-(4-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)butyl)-2,3-dimethoxybenzamide  0   *Benzamides *Isoquinolines Ligands. Bioorg Med Chem 2011 Mar 15;19(6):1852-9
diphosphin 4,6-bis(3-diisopropylphosphinophenyl)dibenzofuran  0   *Benzofurans Ligands. Inorg Chem. 2011 Mar 21;50(6):2545-52
norfloxacin dithiocarbamate  0   Norfloxacin/*analogs & derivatives Ligands. Bioconjug Chem 2011 Mar 16;22(3):369-75
1-phenyl-3-methyl-4-benzoyl-5-pyrazolone  0   *Pyrazoles Ligands. Dalton Trans. 2011 Mar 7;40(9):1969-76
1'-benzyl-3-(2-fluoroethyl)-3H-spiro((2)benzofuran-1,4'-piperidine)  0   *Piperidines *Benzofurans Fluorine Radioisotopes Ligands. Eur J Nucl Med Mol Imaging 2011 Mar;38(3):540-51
2-(4-(methylsulfonyl)phenyl)-3-(3(R)-oxocyclopentyl)propanoic acid  0   *Propionic Acids *Sulfhydryl Compounds Ligands. Chirality. 2011 Mar;23(3):277-80
3-(2'-thienyl)-5-(trifluoromethyl)pyrazolate  0   *Hydrocarbons, Fluorinated *Pyrazoles Ligands. Dalton Trans. 2011 Feb 21;40(7):1601-9
xanthohumol D  0   *Flavonoids Ligands. Anal Chem. 2011 Feb 1;83(3):1048-52
3-(2-(azepan-1-yl)ethyl)-6-propylbenzo(d)thiazol-2(3H)-one  0   *Azepines *Benzothiazoles Ligands Tritium. Eur J Pharmacol 2011 Feb 25;653(1-3):1-7
TSIZ01 compound  0   *Imidazoles Ligands. Bioorg Med Chem Lett 2011 Feb 1;21(3):1004-9
2-(N-cyclopropylmethyl-4,5-epoxy-6,14-ethano-3-hydroxy-6-methoxymorphinan-7-yl)-3,3-dimethylpentan-2-ol  0   Buprenorphine/*analogs & derivatives Ligands Receptors, Opioid. J Pharmacol Exp Ther 2011 Mar;336(3):952-61
PANP protein, human  0   *Nerve Tissue Proteins Ligands. Biochem Biophys Res Commun 2011 Feb 18;405(3):428-33
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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