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Receptors, Dopamine D4

More information in Books or onNLM PubMed
Definition: A subtype of dopamine D2 receptors that has high affinity for the antipsychotic CLOZAPINE.  see SCR for organism-specific terms    Other names D4 Receptors, Dopamine; D4 Receptor, Dopamine; Receptor, Dopamine D4; Dopamine D4 Receptor; Dopamine D4 Receptors
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
1-(2,3-dihydrobenzo(b)(1,4)dioxin-6-yl)-4-((6-fluoropyridin-3-yl)methyl)piperazine  0   *Dioxanes *Piperazines Ligands Receptors, Dopamine D4. J Med Chem. 2011 Dec 22;54(24):8343-52.
N-(2-(4-(3-cyanopyridin-2-yl)piperazin-1-yl)ethyl)-3-methoxybenzamide  0   *Benzamides *Piperazines Receptors, Dopamine D4. J Med Chem 2010 Oct 28;53(20):7344-55
2'-(2-hydroxy-3'-(4-(4-hydroxy-2-methoxyphenyl)-1-piperazinyl)propoxy)acetanilide  0   *Acetanilides *Piperazines Receptors, Dopamine D4/antagonists & inhibitors. J Pharmacol Exp ther 2010 Jun;333(3):682-95
5-(4-(4-chlorophenyl)piperazin-1-ylmethyl)-1H-indole  0   *Indoles *Piperazines Receptors, Dopamine D4/antagonists & inhibitors. Eur J Pharmacol 2007 Nov 14;573(1-3):148-60
3-(1-(2-(1-acetyl-2,3-dihydro-1H-indol-3-yl)ethyl)-3,6-dihydro-2H-pyridin-4-yl)-6-chloro-1H-indole  0   *Dihydropyridines *Indoles Receptors, Dopamine D4/antagonists & inhibitors. Eur J Pharmacol 2007 Nov 14;573(1-3):148-60
3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-(2,4'-bipyridine)-1'-ylmethyl)benzamide  0   *Benzamides *Cyclic N-Oxides Receptors, Dopamine D4. J Med Chem 2006 Dec 14;49(25):7450-65
2-(4-(2-methoxyphenyl)piperazin-1-ylmethyl)imidazo(1,2-a)pyridine  0   *Imidazoles *Pyridines Receptors, Dopamine D4/agonists. J Med Chem 2006 Jun 29;49(13):3938-47
2-(4-(3,4-dimethylphenyl)piperazin-1-ylmethyl)-1H-benzimidazole  0   *Benzimidazoles *Piperazines Receptors, Dopamine D4/antagonists & inhibitors. Neuropharmacology 2005 Jul;49(1):112-21
Drd4 protein, rat  0   *Receptors, Dopamine D4.
Drd4 protein, mouse  0   *Receptors, Dopamine D4.
DRD4 protein, human  0   *Receptors, Dopamine D4.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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