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Benzimidazoles

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Definition: Compounds with a BENZENE fused to IMIDAZOLES.     
See Also Imidazoles
Examples 2-Pyridinylmethylsulfinylbenzimidazoles; Albendazole; Astemizole; Benomyl; Bisbenzimidazole; Cambendazole; Domperidone; Droperidol; Fenbendazole; Mebendazole; Mibefradil; Nocodazole; Pimozide; Thiabendazole
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2-(2-benzimidazolyl)-5-(4-(2-imidazolino)phenyl)furan  0   *Benzimidazoles *Furans. Antivir Chem Chemother. 2012;22(4):171-9.
1,3-bis(1-methylbenzimidazol-2-yl)-2-oxapropane  0   *Benzimidazoles. J Photochem Photobiol B. 2011 Dec 2;105(3):190-7
2-chloromethyl-1H-benzimidazole hydrochloride  0   *Benzimidazoles. Spectrochim Acta A Mol Biomol Spectrosc. 2012 Feb;86():605-13
2-(4-((4-(acetylamino)-4'-chloro-(1,1'-biphenyl)-2-yl)methoxy)phenyl)-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid  0   *Acetamides *Benzimidazoles RNA Replicase/antagonists & inhibitors. Antiviral Res. 2012 Jan;93(1):30-8.
4-(1-(2-(4-((2-(4-chloro-1H-pyrazol-1-yl)ethyl)amino)-2-oxo-1,2-dihydropyridin-3-yl)-4-methyl-1H-benzo(d)imidazol-6-yl)piperidin-4-yl)piperazine-1-carboxylate  0   *Benzimidazoles *Piperazines Receptor, IGF Type 1/antagonists & inhibitors. J Pharmacol Exp Ther. 2012 Mar;340(3):688-97.
5-methyl-1-oxo-2,3,4,5-tetrahydro-1H-(1,4)diazepino(1,2-a)indole-8-carboxylic acid (1-(3-dimethylamino-propyl)-1H-benzoimidazol-2-yl)amide  0   *Azepines *Benzimidazoles Ribosomal Protein S6 Kinases/antagonists & inhibitors. J Pharmacol Exp Ther. 2012 Mar;340(3):492-500.
TOK-001  0   *Androstadienes *Benzimidazoles Prostatic Neoplasms/drug therapy. Nature. 2012 Feb 2;482(7383):116-9
5-(3-((3-(5-methoxybenzisoxazol-3-yl)benzimidazol-1-yl)methyl)phenyl)-5-methyloxazolidinedione  0   *Benzimidazoles Dimethadione/*analogs & derivatives PPAR gamma. J Med Chem. 2011 Dec 22;54(24):8541-54.
CPUYJ039  0   *Benzimidazoles Antimitotic Agents. Pharm Pharmacol. 2011 Nov;63(11):1462-9
2-((1H-benzimidazol-2-ylmethyl)amino)benzoic acid methyl ester  0   *Anthranilic Acids *Benzimidazoles. Spectrochim Acta A Mol Biomol Spectrosc. 2011 Oct 15;81(1):754-63.
1H-benzimidazol-2-ylmethyl-N-phenylamine  0   *Aniline Compounds *Benzimidazoles. Spectrochim Acta A Mol Biomol Spectrosc. 2011 Oct 15;81(1):529-43.
3-(4-(ethylthio)-1H-benzimidazol-2-yl)isoquinoline  0   *Benzimidazoles *Isoquinolines Adrenergic alpha-1 Receptor Antagonists. ChemMedChem. 2011 Oct 4;6(10):1909-18.
(N-methoxy-N-methyl)-4-(5-benzoylbenzimidazole-2-yl)-3,5-dimethylpyrrole-2-carboxamide hydrochloride  0   *Benzimidazoles *Pyrroles. Eur J Pharmacol. 2011 Sep 30;667(1-3):389-95
GSK 1034702  0   *Benzimidazoles Carbon Radioisotopes Receptor, Muscarinic M1/agonists. Appl Radiat Isot. 2011 Oct;69(10):1390-4.
GSK 1997132B  0   *Benzimidazoles. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5568-72.
2-(1-aminoisobutyl)-1-(3-chlorobenzyl)benzimidazole  0   *Benzimidazoles. J Med Chem. 2011 Oct 13;54(19):6993-7.
5-methyl-2(pyridine-3-yl)-1-(3,4,5-trimethoxybenzyl)benzimidazole  0   *Benzimidazoles Antineoplastic Agents. Mol Carcinog. 2011 Oct;50(10):791-803
5-(1H-benzoimidazol-2-ylmethylsulfanyl)-2-methyl(1,2,4)triazolo(1,5-c)quinazoline  0   *Benzimidazoles *Quinazolines. Bioorg Med Chem Lett 2011 Jun 15;21(12):3738-42
3-(7-trifluoromethyl-5-(2-trifluoromethylphenyl)-1H-benzimidazol-2-yl)-1-oxa-2-azaspiro(4.5)dec-2-ene  0   *Benzimidazoles *Isoxazoles TRPM Cation Channels/antagonists & inhibitors. J Med Chem 2011 Jan 13;54(1):233-47
GSK 461364  0   *Benzimidazoles *Thiophenes. Clin Cancer Res 2011 May 15;17(10):3420-30
2-(4-chloro-3-nitrophenyl)-5(6)-nitro-1H-benzimidazole  0   *Benzimidazoles *Nitrobenzenes. Arch Pharm Res. 2011 Feb;34(2):181-9
1-(benzimidazol-2-ylmethyl)-1,4, 8,11-tetraazacyclotetradecane  0   *Aza Compounds *Benzimidazoles. Inorg Chem. 2011 May 2;50(9):4029-38
1-(5-chloro-6-(trifluoromethoxy)-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid  0   *Benzimidazoles *Pyrazoles Procollagen-Proline Dioxygenase/antagonists & inhibitors. Mol Pharmacol 2011 Jun;79(6):910-20
ITP 79  0   *Benzimidazoles *Thiazolidines. Mol Cancer Ther 2011 Apr;10(4):626-36
ciliabrevin  0   *Benzimidazoles *Benzylamines. Cytoskeleton (Hoboken) 2011 Mar;68(3):188-203
4,5-bis(benzimidazol-2-yl)imidazole  0   *Benzimidazoles. J Phys Chem A. 2011 Mar 17;115(10):1985-91
4-(5-(1-methylpiperidin-4-yloxy)-1H-benzo(d)imidazol-1-yl)-2-(1-(2-(trifluoromethyl)phenyl)ethoxy)benzamide  0   *Benzamides *Benzimidazoles. J Med Chem 2011 Mar 24;54(6):1626-39
2-(2-(3-hydroxymorpholin-4-yl)ethylthio)-5-ethoxybenzimidazole  0   *Benzimidazoles *Morpholines. Bull Exp Biol Med 2010 Sep;149(3):318-9
1,1',3,3'-tetraethyl-5,5',6,6'-tetrachloro-benzimidazolocarbocyanine iodide  0   *Benzimidazoles *Carbocyanines. J Chem Phys. 2011 Feb 14;134(6):064325
4-(2-(2-(4-chlorophenyl)-5,6-difluorobenzoimidazol-1-yl)-2-cyclohexylacetylamino)-3-fluorobenzoic acid  0   *Benzimidazoles 4-Aminobenzoic Acid/*analogs & derivatives. Bioorg Med Chem Lett 2011 Feb 15;21(4):1134-40
2,6-bis(5,6-dihydrobenzo(4,5)imidazo(1,2-c)quinazolin-6-yl)-4-methylphenol  0   *Benzimidazoles *Quinazolines. Inorg Chem. 2011 Feb 21;50(4):1213-9
6-chloro-5-(1-naphthyloxy)-2-(trifluoromethyl)-1H-benzimidazole  0   *Benzimidazoles Trichinella/drug effects. Bioorg Med Chem. 2011 Jan 15;19(2):789-97
SB939 compound  0   *Benzimidazoles Histone Deacetylase Inhibitors. Br J Cancer. 2011 Mar 1;104(5):756-62
azilsartan medoxomil  0   *Benzimidazoles *Oxadiazoles Angiotensin II Type 1 Receptor Blockers. Hypertension 2011 Mar;57(3):413-20
BC76 compound  0   *Benzimidazoles *Pyrroles Cyclic Nucleotide Phosphodiesterases, Type 5. Cell Signal 2011 Mar;23(3):594-601
1,4-di(1H-imidazol-4-yl)benzene  0   *Benzimidazoles. Chem Commun (Camb). 2011 Jan 14;47(2):752-4
2-(4-bromophenyl)-1H-benzimidazole  0   *Benzimidazoles. Spectrochim Acta A Mol Biomol Spectrosc. 2011 Jan;78(1):319-26
2,2',2''-(benzene-1,3,5-triyl)-tri(1-phenyl-1H-benzimidazole)  0   *Benzimidazoles. Chemistry. 2011 Feb 25;17(9):2647-55
methyl 2-(4-bromophenyl)-1-(5-tert-butyl-1H-pyrazol-3-yl)-1H-benzimidazole-5-carboxylate  0   *Benzimidazoles *Pyrazoles. Acta Crystallogr C. 2011 Feb;67(Pt 2):o64-6
N-(4-fluorobenzyl)-4-furan-2-methyl-1,4-dihydrobenzo(4,5)imidazo(1,2-a)pyrimidine-3-carboxamide  0   *Benzimidazoles *Pyridines. Bioorg Med Chem 2010 Nov 15;18(22):8035-43
N-(4-methoxybenzyl)-4-furan-2-methyl-1,4-dihydrobenzo(4,5)imidazo(1,2-a)pyrimidine-3-carboxamide  0   *Benzimidazoles *Pyridines. Bioorg Med Chem 2010 Nov 15;18(22):8035-43
N-(1-(cyclohexylmethyl)-2-((5-ethoxypyridin-2-yl)methyl)-1H-benzo(d)imidazol-5-yl)-N-methylthiophene-2-sulfonamide  0   *Benzimidazoles *Sulfonamides Receptor, Cannabinoid, CB1/agonists. Pain 2010 Nov;151(2):337-44
(1-(4-(2-(hexahydropyrrolo(3,4-c)pyrrol-2(1H)-yl)-1H-benzimidazol-1-yl)piperidin-1-yl)cyclooctyl)methanol  0   *Benzimidazoles *Pyrroles. Bioorg Med Chem 2010 Nov 1;18(21):7675-99
N-(2-(4-(4-iodobenzyl)piperidin-1-ylmethyl)benzoimidazol-5-yl)-methanesulfonamide  0   *Benzimidazoles *Sulfonamides Iodine Radioisotopes. Bioorg Med Chem 2010 Nov 1;18(21):7497-506
2-((4-(4-iodobenzyl)piperidin-1-yl)methyl)benzimidazol-5-ol  0   *Benzimidazoles Iodine Radioisotopes. Bioorg Med Chem 2010 Nov 1;18(21):7497-506
5-(benzimidazolium-2-yl)salicylate  0   *Benzimidazoles *Salicylic Acids. Acta Crystallogr C. 2010 Dec;66(Pt 12):o596-9
4-(1-(naphthylmethyl)benzimidazol-2-ylthio)butanoic acid  0   *Benzimidazoles *Butyrates Chymases/antagonists & inhibitors. J Cardiovasc Pharmacol 2003 Jan;41 Suppl 1:S11-8
N-((2-(((4-(aminoiminomethyl)phenyl)amino)methyl)-1-methyl-1H-benzimidazol-5-yl)carbonyl)-N-2-pyridinyl-beta-alanine  0   *Benzimidazoles beta-Alanine/*analogs & derivatives. Drug Metab Dispos 2010 Sep;38(9):1567-75
TAS-203  223909-92-0   *Benzimidazoles *Triazoles. Arzneimittelforschung. 2010;60(9):564-70
benzimidazo(1,2-c)quinazolin-6(5h)-thione  0   *Benzimidazoles *Quinazolines *Thiones Anti-Infective Agents. Pak J Pharm Sci. 2010 Oct;23(4):459-62
2-phenyl-5-(pyrrolidin-1-yl)-1-(3,4,5-trimethoxybenzyl)-1H-benzimidazole  0   *Anisoles *Benzimidazoles. Br J Pharmacol 2010 Aug;160(7):1677-89
2,2'-(1,3-phenylene)-bis-(5-(4-(2-hydroxyethyl)-1-piperazinyl)-1H-benzimidazole)  0   *Benzimidazoles *Piperazines Telomerase/antagonists & inhibitors. Bioconjug Chem 2010 Jul 21;21(7):1148-59
2,2'-(1,4-phenylene)-bis-(5-(4-(2-hydroxyethyl)-1-piperazinyl)-1H-benzimidazole)  0   *Benzimidazoles *Piperazines Telomerase/antagonists & inhibitors. Bioconjug Chem 2010 Jul 21;21(7):1148-59
2-(1-thieno(3,2-d)pyrimidin-4-ylpiperidin-4-yl)thiazole-4-carboxylic acid (6-benzoyl-1H-benzoimidazol-2-yl)amide  0   *Benzimidazoles *Thiazoles. Mol Cancer Ther 2010 Feb;9(2):300-10
2-amino-N-(3-(biphenyl-4-yl)-1-(2-(5,6-dichloro-1H-benzimidazol-2-yl)pyrrolidin-1-yl)-1-oxobutan-2-yl)-2-methylpropanamide  0   *Benzimidazoles Phenylalanine/*analogs & derivatives. J Med Chem 2010 Oct 14;53(19):7251-63
2-amino-3-methylimidazo(1,2-d)naphthalene  0   *Benzimidazoles. Chem Res Toxicol 2010 Jun 21;23(6):1076-88
2-(4-(2,2-dimethyl-1,3-dioxan-5-yl)methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl-1H-benzimidazole  0   *Benzimidazoles *Sulfoxides. J Pharmacol Exp Ther 2010 Aug;334(2):395-401
1-(1-cyclooctylmethyl-5-(1-hydroxy-1-methylethyl)-1,2,3,6-tetrahydropyridin-4-yl)-3-ethyl-1,3-dihydrobenzoimidazol-2-one  0   *Benzimidazoles *Cyclooctanes Receptors, Opioid/antagonists & inhibitors. Peptides 2010 Jun;31(6):1194-204
5-methylbenzimidazole  0   *Benzimidazoles. J Biol Chem 2001 Oct 5;276(40):37612-20
1,1'-bis(N-benzimidazolylidene)ferrocene  0   *Benzimidazoles *Ferrous Compounds. Dalton Trans 2009 Sep 21;(35):7253-61
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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