encyclopedia of medical concepts
ψ
ψ
ψ
PPAR gamma
More information
in Books
or on
Definition
: A nuclear transcription factor. Heterodimerization with RETINOID X RECEPTOR ALPHA is important in regulation of GLUCOSE metabolism and CELL GROWTH PROCESSES. It is a target of THIAZOLIDINEDIONES for control of DIABETES MELLITUS.
Other names
PPARgamma; Receptor, Thiazolidinedione; Peroxisome Proliferator Activated Receptor gamma; mPPARgamma2; mPPARgamma1; Thiazolidinedione Receptor; Peroxisome Proliferator-
Activated Receptor gamma; PPARgamma3; PPARgamma2
Substance
CAS Registry & name
Categories
Source
Drugs
*
2-
(2,4-
hexadienoyl)-
7-
(2-
(5-
methyl-
2-
(5-
methylhexen-
1-
yl)oxazol-
4-
yl)ethoxy)-
1,2,3,4-
tetrahydroisoquinoline-
3-
carboxylic acid
0
*Isoquinolines
*Oxazoles
PPAR gamma/agonists.
Bioorg Med Chem. 2012 Jan 15;20(2):1060-75.
5-
(3-
((3-
(5-
methoxybenzisoxazol-
3-
yl)benzimidazol-
1-
yl)methyl)phenyl)-
5-
methyloxazolidinedione
0
*Benzimidazoles
Dimethadione/*analogs & derivatives
PPAR gamma.
J Med Chem. 2011 Dec 22;54(24):8541-54.
(S)-
2-
(2,4-
hexadienoyl)-
7-
(2-
(5-
methyl-
2-
phenyloxazol-
4-
yl)ethoxy)-
1,2,3,4-
tetrahydroisoquinoline-
3-
carboxylic acid
0
*Tetrahydroisoquinolines
PPAR alpha/agonists
PPAR gamma/agonists.
Chem Pharm Bull (Tokyo). 2011;59(7):876-9
3-
(5-
(2-
(1H-
tetrazol-
5-
yl)phenyl)-
2,3-
dihydro-
1H-
inden-
1-
yl)-
2-
ethyl-
5-
isobutyl-
7-
methyl-
3H-
imidazo(4,5-
b)pyridine
0
*Imidazoles
*Pyridines
Angiotensin II Type 1 Receptor Blockers
PPAR gamma/agonists.
J Med Chem 2011 Jun 23;54(12):4219-33
5-
(5-
(3-
chloro-
5-
ethoxy-
4-
hydroxybenzylidene)-
3-
methyl-
4-
oxothiazolidin-
2-
ylideneamino)-
2-
chlorobenzoic acid
0
*Aminobenzoic Acids
*Thiazolidines
PPAR gamma/antagonists & inhibitors.
J Steroid Biochem Mol Biol 2011 Apr;124(3-5):112-20
2-
(((4-
methoxyphenoxy)carbonyl)(1-
(4-
(2-
(5-
methyl-
2-
phenyloxazol-
4-
yl)ethoxy)phenyl)ethyl)amino)acetic acid
0
*Oxazoles
Glycine/*analogs & derivatives
PPAR alpha/agonists
PPAR gamma/agonists.
Drug Metab Dispos 2011 Feb;39(2):228-38
CG 301269
0
*Oxazoles
*Thiazolidines
PPAR alpha/agonists
PPAR gamma/agonists.
Diabetes 2011 Feb;60(2):496-506
2-
ethoxy-
3-
(4-
(3-
methyl-
5-
(4-
(3-
methylisoxazol-
5-
yl)phenyl)thiophen-
2-
ylmethoxy)phenyl)propionic acid
0
*Phenylpropionates
*Thiophenes
PPAR gamma/agonists.
Arch Pharm Res 2010 Sep;33(9):1389-94
(E)-
12-
nitrooctadec-
12-
enoic acid
0
*Linoleic Acids
*Nitro Compounds
PPAR gamma/agonists.
J Org Chem. 2010 Dec 3;75(23):8311-4
(5-
(3-
(4-
(biphenyl-
4-
ylcarbonyl)phenoxy)propoxy)-
1H-
indol-
1-
yl)acetic acid
0
*Benzophenones
*Indoleacetic Acids
PPAR gamma/agonists.
ChemMedChem 2010 Oct 4;5(10):1707-16
1-
(4-
(2-
(5-
methyl-
2-
p-
tolyloxazol-
4-
yl)ethoxy)benzyl)piperidine-
2-
carboxylic acid
0
*Oxazoles
*Pipecolic Acids
PPAR alpha/agonists
PPAR gamma/agonists.
Mol Pharmacol 2010 Nov;78(5):877-85
lobeglitazone
0
*Pyrimidines
*Thiazolidinediones
PPAR alpha/agonists
PPAR gamma/agonists.
J Pharm Biomed Anal 2009 Dec 5;50(5):872-7
2-
(4-
(2-
Fluoro-
benzenesulphonyl)-
piperazin-
1-
yl)-
3-
(4-
(2-
(5-
methyl-
2-
phenyl-
oxazol-
4-
yl)-
ethoxy)phenyl)propionic acid
0
*Phenylpropionates
*Sulfonamides
PPAR alpha/agonists
PPAR gamma/agonists.
Br J Pharmacol 2009 Jul;157(5):724-35
1-
0-
hexadecyl-
2-
azelaoyl-
sn-
glycero-
3-
phosphocoline
0
Phosphorylcholine/*analogs & derivatives
PPAR gamma/agonists.
Cerebellum. 2009 Jun;8(2):98-103
INT 131
0
*Quinolines
*Sulfonamides
PPAR gamma/agonists.
Curr Opin Investig Drugs 2009 Apr;10(4):381-7
2-
(1-
(3-
(4-
(biphenyl-
4-
carbonyl)-
2-
propylphenoxy)propyl)-
1,2,3,4-
tetrahydroquinolin-
5-
yloxy)-
2-
methylpropionic acid
0
*Hydroxybutyrates
*Quinolines
PPAR gamma/agonists.
J Med Chem 2009 Apr 23;52(8):2618-22
KR 62776
0
*Indans
*Oximes
PPAR gamma/agonists.
Biochem Biophys Res Commun 2009 Jan 16;378(3):645-9
KV-
5070
0
*Tetrahydroisoquinolines
PPAR gamma/agonists.
Naunyn Schmiedebergs Arch Pharmacol 2008 Jun;377(4-6):401-10
2-
methyl-
2-
((1-
(3-
phenyl-
7-
propylbenzo(d)isoxazol-
6-
yl)oxy)propyl)-
1H-
4-
indolyloxypropanoic acid
0
*Indoles
*Propionic Acids
DNA Topoisomerases, Type II/antagonists & inhibitors
PPAR alpha/agonists
PPAR gamma/agonists.
Anticancer Drugs 2008 Feb;19(2):151-8
4-
hydroxydocasahexaenoic acid
0
*Fatty Acids, Unsaturated
PPAR gamma/agonists.
Biochem Biophys Res Commun 2008 Mar 14;367(3):566-72
2-
cyanolup-
1-
en-
3-
oxo-
20-
oic acid
0
*Triterpenes
PPAR gamma/agonists.
Carcinogenesis 2007 Nov;28(11):2337-46
methyl 7-
(2-
(5-
methyl-
2-
phenyloxazol-
4-
yl)ethoxy)coumarin-
7-
carboxylate
0
*Coumarins
*Oxazoles
PPAR alpha/agonists
PPAR gamma/agonists.
Bioorg Med Chem Lett 2003 Oct 20;13(20):3437-40
naveglitazar
0
*Phenylpropionates
PPAR alpha/agonists
PPAR gamma/agonists.
Drug Metab Dispos 2007 Jan;35(1):51-61
2-
bromo-
5-
nitro-
N-
phenylbenzamide
0
*Anilides
*Benzamides
Bromine Radioisotopes
PPAR gamma/antagonists & inhibitors.
Nucl Med Biol 2006 Oct;33(7):847-54
3-
(4-
(2-
(5-
methyl-
2-
phenyloxazol-
4-