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Coumarins

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Definition: Synthetic or naturally occurring substances related to coumarin, the delta-lactone of coumarinic acid. The various coumarins have a wide range of proposed actions and uses including as ANTICOAGULANTS, pharmaceutical aids, indicators and reagents, photoreactive substances, and ANTINEOPLASTIC AGENTS.     
Pharmacological Action Anticoagulants; Antineoplastic Agents; Indicators and Reagents
See Also Anticoagulants; Indicators and Reagents; Pharmaceutic Aids; Pyrones
Examples Aminocoumarins; Chromonar; Coumestrol; Esculin; 4-Hydroxycoumarins; Isocoumarins; Psoralens; Pyranocoumarins; Umbelliferones 		Other names 1,2-Benzopyrones; Benzopyran 2 ones; 1,2 Benzopyrones; 1,2 Benzo Pyrones; Coumarines; Benzopyran-2-ones; 1,2-Benzo-Pyrones
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
trans-avicennol  0   *Coumarins *Pyrones Antineoplastic Agents, Phytogenic. J Nat Prod. 2012 Feb 24;75(2):257-61
7((2E)-4(4,5-dihydro-3-methylene-2-oxo-5-furanyl)-3-methylbut-2-enyloxy)  0   *Coumarins. Fitoterapia. 2012 Jan;83(1):230-3
8-hydroxy-4-methyl-benzo(g)chromen-2-one  0   *Coumarins Casein Kinase II/antagonists & inhibitors. Cell Mol Life Sci. 2012 Feb;69(3):449-60.
8-hydroxy-4-methyl-9-nitrobenzo(g)chromen-2-one  0   *Coumarins Casein Kinase II/antagonists & inhibitors. Cell Mol Life Sci. 2012 Feb;69(3):449-60.
bicoumol-7-O-beta-glucopyranoside  0   *Coumarins *Glucosides. J Asian Nat Prod Res. 2011 Dec;13(12):1074-80
bicoumol-7'-O-beta-glucopyranoside  0   *Coumarins *Glucosides. J Asian Nat Prod Res. 2011 Dec;13(12):1074-80
6-methoxy-3-(4-methylphenyl)coumarin  0   *Coumarins Monoamine Oxidase Inhibitors. J Med Chem. 2011 Oct 27;54(20):7127-37.
4-(4-fluorophenyl)-7-(((5-(1-hydroxy-1-(trifluoromethyl)propyl)-1,3,4-oxadiazol-2-yl)amino)methyl)-2H-1-benzopyran-2-one  0   *Coumarins *Oxadiazoles Lipoxygenase Inhibitors. Drug Metab Dispos. 2011 May;39(5):763-70.
katimborine  0   *Coumarins *Glycosides Antimalarials. J Nat Prod. 2011 Oct 28;74(10):2286-9
omubioside  0   *Coumarins *Glycosides Antimalarials. J Nat Prod. 2011 Oct 28;74(10):2286-9
beccamarin  0   *Coumarins. Molecules. 2011;16(9) (dup#20):7249-55
(1'S,2'R)-8-(2,3-epoxy-1-hydroxy-3-methylbutyl)-7-methoxycoumarin  0   *Coumarins. Fitoterapia. 2011 Jul;82(5):767-71
7-azido-4-(bromomethyl)coumarin  0   *Azides *Coumarins. Nucleic Acids Res 2011 Sep 1;39(16):7348-60
nothospondin  0   *Coumarins *Phenanthrenes. Bioorg Med Chem Lett 2011 Aug 1;21(15):4397-9
3-acetyl-7-(4-hydroxyphenyl)-2H-chromen-2-one  0   *Coumarins 17-Hydroxysteroid Dehydrogenases/antagonists & inhibitors. J Med Chem 2011 Jan 13;54(1):248-61
astrotricoumarin  0   *Coumarins Antineoplastic Agents, Phytogenic. Nat Prod Commun. 2011 Sep;6(9):1259-62
BNS 22  0   *Coumarins *Quinolines DNA Topoisomerases, Type II Topoisomerase Inhibitors. Chem Biol 2011 Jun 24;18(6):
6-bromo-8-methoxy-3-(4'-methoxyphenyl)coumarin  0   *Coumarins Monoamine Oxidase Inhibitors. Bioorg Med Chem Lett 2011 Jul 15;21(14):4224-7
7-(3',7'-dimethyl-6'-oxo-2',7'-octadienyl)oxycoumarin  0   *Coumarins. Arch Pharm Res 2011 May;34(5):723-6
IMMLG5521  0   *Coumarins. Eur J Pharmacol. 2011 Jul 1;661(1-3):118-23
paniculacin  0   *Coumarins. J Asian Nat Prod Res. 2011 Aug;13(8):724-7
lucidafuranocoumarin A  0   *Furans *Coumarins. J Asian Nat Prod Res. 2011 Jun;13(6):556-60
3,5-dimethyl-7H-furo(3,2-g)chromen-7-one  0   *Benzofurans *Coumarins. Chemotherapy 2011;57(2):162-72
flemicoumestan A  0   *Coumarins. Fitoterapia. 2011 Jun;82(4):615-9
monapinone B  0   *Coumarins. J Antibiot (Tokyo). 2011 Jul;64(7):503-8
monapinone A  0   *Coumarins. J Antibiot (Tokyo). 2011 Jul;64(7):503-8
dinapinone A  0   *Coumarins. J Antibiot (Tokyo). 2011 Jul;64(7):489-94
isoarnottinin 4'-glucoside  0   *Coumarins *Glucosides. Bioorg Khim. 2011 Mar-Apr;37(2):269-72
fusariumin  0   *Coumarins. Bioorg Med Chem Lett 2011 Mar 15;21(6):1887-9
vipirinin  0   *Carbamates *Coumarins. J Biol Chem 2011 Apr 22;286(16):14049-56
8-deshydroxyajudazol B  0   *Coumarins. Org Lett. 2011 Apr 15;13(8):1964-7
7-(3,4-difluorophenoxy)-4-(1H-imidazol-1-ylmethyl)-2H-chromen-2-one  0   *Coumarins *Imidazoles Aromatase Inhibitors. J Med Chem 2011 Mar 24;54(6):1613-25
3-O-(E)-p-coumaroyl tormentic acid  0   *Coumarins *Triterpenes. Chem Pharm Bull (Tokyo). 2011;59(3):378-81
3-aminohexahydrocoumarin  0   *Coumarins. Eur J Med Chem. 2011 Mar;46(3):953-60
asimafoetidnol  0   *Coumarins *Sesquiterpenes. Nat Prod Commun. 2011 Feb;6(2):209-12
4-((4'-methoxyphenyl)amino)-7,8,9,10-tetrahydro-2H-benzo(h)chromen-2-one  0   *Aniline Compounds *Coumarins. Bioorg Med Chem Lett 2011 Jan 1;21(1):546-9
diosfeboside B  0   *Coumarins *Glycosides. Fitoterapia. 2010 Oct;81(7):873-7
diosfeboside A  0   *Coumarins *Glycosides. Fitoterapia. 2010 Oct;81(7):873-7
RKS 262  0   *Coumarins *Cyclic S-Oxides. Invest New Drugs 2011 Feb;29(1):63-72
(7-diethylaminocoumarin-4-yl)methyl phosphate  0   *Coumarins. J Phys Chem A. 2010 Dec 16;114(49):12795-803
5,6-benzo-4-azidomethyl coumarin  0   *Coumarins. J Fluoresc. 2010 Nov;20(6):1175-80
Tral-1 compound  0   *Coumarins. J Enzyme Inhib Med Chem. 2010 Dec;25(6):854-62
stellatin  0   *Coumarins. J Asian Nat Prod Res. 2011 Feb;13(2):97-104
mesuagenin B  0   *Coumarins Cholinesterase Inhibitors. Bioorg Med Chem 2010 Nov 15;18(22):7873-7
6,7-dihydroxy-4-phenylcoumarin  0   *Coumarins. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5630-3
poly(styrene-alt-maleic anhydride)-co-poly(7-(4-vinylbenzyloxyl)-4-methylcoumarin-alt-malic anhydride)  0   *Coumarins *Polystyrenes. J Colloid Interface Sci 2010 Nov 15;351(2):315-22
Mammea E/BB compound  0   *Coumarins. J Nat Prod. 2010 Nov 29;73(11):1868-72
(Cu((7-hydroxy-4-methyl-8-coumarinyl)leucine)phen(H2O))ClO4  0   *Coumarins *Organometallic Compounds Leucine/*analogs & derivatives Copper. Chem Pharm Bull (Tokyo). 2010;58(8):1003-8
(Cu((7-hydroxy-4-methyl-8-coumarinyl)valine)phen(H2O))ClO4  0   *Coumarins *Organometallic Compounds Valine/*analogs & derivatives Copper. Chem Pharm Bull (Tokyo). 2010;58(8):1003-8
7-((2'E,6'E)-7'-carboxy-5'(zeta)-hydroxy-3'-methylocta-2',6'-dienyloxy)-coumarin  0   *Coumarins. Fitoterapia. 2010 Sep;81(6):656-8
flabellilobin B  0   *Coumarins *Sesquiterpenes. Pharm Biol. 2010 Feb;48(2):217-20
flabellilobin A  0   *Coumarins *Sesquiterpenes. Pharm Biol. 2010 Feb;48(2):217-20
farnesiferone B  0   *Coumarins *Sesquiterpenes. Pharm Biol. 2010 Feb;48(2):217-20
sarcandracoumarin  0   *Coumarins. Fitoterapia. 2010 Sep;81(6):472-4
farnesiferol C  0   *Coumarins Receptors, Vascular Endothelial Growth Factor/antagonists & inhibitors. Mol Cancer Ther 2010 Feb;9(2):389-99
7,8-dipropoxy-4-methylcoumarin  0   *Coumarins. J Biochem 2010 May;147(5):625-32
coumarin 343  0   *Coumarins. J Phys Chem A. 2010 Jul 15;114(27):7326-30
6-hydroxy-7-methoxy-4-(4-methoxyphenyl)-2H-1-benzopyran-2-one  0   *Coumarins. Phytochemistry 2010 Jul;71(10):1122-31
O-methylnotopterol  0   *Coumarins. Zhongguo Zhong Yao Za Zhi. 2010 May;35(9):1134-6
6,6',7,7'-tetramethoxyl-8,8'-biscoumarin  0   *Coumarins. J Asian Nat Prod Res. 2010 Aug;12(8):707-13
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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