encyclopedia of medical concepts
ψ 

Aromatase Inhibitors

More information in Books or onNLM PubMed
Definition: Compounds that inhibit AROMATASE in order to reduce production of estrogenic steroid hormones.      Other names Inhibitors, Aromatase
Substances having this pharmacologic action: intraovarian peptides; plomestane; anastrozole; Fadrozole; Aminoglutethimide; formestane; letrozole; vorozole; exemestane
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
7-(3,4-difluorophenoxy)-4-(1H-imidazol-1-ylmethyl)-2H-chromen-2-one  0   *Coumarins *Imidazoles Aromatase Inhibitors. J Med Chem 2011 Mar 24;54(6):1613-25
5alpha-androst-3-en-17-one oxime  0   *Oximes *17-Ketosteroids Aromatase Inhibitors. Acta Crystallogr C. 2008 Sep;64(Pt 9):o508-10
4,5-epoxyandrostenedione  0   Androstenedione/*analogs & derivatives Aromatase Inhibitors. Steroids 2002 Mar;67(3-4):185-93
2',4'-dihydroxy-2''-(1-hydroxy-1-methylethyl)dihydrofuro(2,3-h)flavanone  0   *Flavanones Aromatase Inhibitors. J Nat Prod 2001 Oct;64(10):1286-93
demethylmoracin I  0   *Benzofurans Aromatase Inhibitors. J Nat Prod 2001 Oct;64(10):1286-93
3'-hydroxymethylmethylallyl-2,4,2',4'-tetrahydroxychalcone 11'-O-coumarate  0   *Terpenes *Chalcones Aromatase Inhibitors. J Nat Prod 2001 Oct;64(10):1286-93
isogemichalcone C  0   *Terpenes *Chalcones Aromatase Inhibitors. J Nat Prod 2001 Oct;64(10):1286-93
5,7,2',4'-tetrahydroxy-3-geranylflavone  0   *Flavonoids Aromatase Inhibitors. J Nat Prod 2001 Oct;64(10):1286-93
MEN 11066  0   *Benzofurans *Triazoles Aromatase Inhibitors. Eur J Pharmacol 2000 Dec 8;409(2):93-101
TZA 2237  0   *Androstadienes Aromatase Inhibitors. Eur J Endocrinol 2000 Oct;143(4):543-54
3'-demethoxysecoisolariciresinol  0   *Phenols *Lignans Aromatase Inhibitors. Steroids 2000 Aug;65(8):437-41
3-demethoxy-3'-O-demethylmatairesinol  0   *Catechols 4-Butyrolactone/*analogs & derivatives Aromatase Inhibitors. Steroids 2000 Aug;65(8):437-41
androst-4-ene-6,17-dione  0   Androstenedione/*analogs & derivatives Aromatase Inhibitors. Biol Pharm Bull 1999 Oct;22(10):1134-6
androst-5-ene-4,17-dione  0   Androstenedione/*analogs & derivatives Aromatase Inhibitors. Biol Pharm Bull 1999 Oct;22(10):1134-6
MR 20494  0   *Indolizines *Pyridines Aromatase Inhibitors. J Steroid Biochem Mol Biol 1999 Jul-Aug;70(1-3):59-71
19-hydroxyandrost-5-ene-4,17-dione  0   Androstenedione/*analogs & derivatives Aromatase Inhibitors. Steroids 1999 May;64(5):320-7
androst-5-ene-4,17,19-trione  0   Androstenedione/*analogs & derivatives Aromatase Inhibitors. Steroids 1999 May;64(5):320-7
6-oxoandrostenedione  0   Androstenedione/*analogs & derivatives Aromatase Inhibitors. Yakugaku Zasshi 1998 Dec;118(12):539-53
MR 20492  0   *Indolizines *Pyridines Aromatase Inhibitors. Bioorg Med Chem Lett 1998 May 5;8(9):1041-4
1,4,6-androstatrien-3,17-dione  0   *Androstatrienes Aromatase Inhibitors. Mol Cell Biochem 1998 Oct;187(1-2):133-9
dexaminoglutethimide  0   *Glutethimide Aromatase Inhibitors. J Clin Endocrinol Metab 1998 Aug;83(8):2687-93
finrozole  0   *Nitriles *Triazoles Aromatase Inhibitors. Br J Clin Pharmacol 1998 Feb;45(2):141-6
6-ethylandrosta-1,4,6-triene-3,17-dione  0   *Androstatrienes Aromatase Inhibitors. Steroids 1997 Aug-Sep;62(8-9):595-602
YM 553  0   *Pyrimidines Aromatase Inhibitors. Chem Pharm Bull (Tokyo) 1997 Aug;45(8):1293-9
5,6-epoxyandrosta-7,17,19-trione  0   *Androstanes Aromatase Inhibitors. Steroids 1997 Jul;62(7):516-22
androst-5-ene-7,17-dione  0   Androstenedione/*analogs & derivatives Aromatase Inhibitors. Steroids 1997 Jul;62(7):516-22
2-(imidazol-1-yl)-4,6-dimorpholino-1,3,5-triazine  0   *Imidazoles *Triazines Aromatase Inhibitors. Endocr Res 1997 Feb-May;23(1-2):1-13
19-(cyclopropylamino)androst-4-en-3,17-dione  0   Androstenedione/*analogs & derivatives Aromatase Inhibitors. J Enzym Inhib 1996;10(1):47-56
4,5-epoxyandrosta-3,6,17,19-tetraone  0   Androstenedione/*analogs & derivatives Aromatase Inhibitors. Biochem Pharmacol 1996 Oct 25;52(8):1253-9
TZA 2209  0   Testolactone/*analogs & derivatives Aromatase Inhibitors. Prostate 1996 May;28(5):328-37
FR 901537  161162-21-6   Pantetheine/*analogs & derivatives Aromatase Inhibitors. J Antibiot (Tokyo) 1995 Aug;48(8):757-62
YM 511  0   *Triazoles Aromatase Inhibitors. J Steroid Biochem Mol Biol 1995 Sep;54(5-6):265-71
MFT 279  0   *Pyridazines Aromatase Inhibitors. Arzneimittelforschung 1995 Aug;45(8):897-900
4-phenoxy-7-phenylthio-4-androstene-3,17-dione  0   Androstenedione/*analogs & derivatives Aromatase Inhibitors. J Med Chem 1995 Sep 29;38(20):4135-8
4-phenylthio-1,4-androstadiene-3,17-dione  164080-14-2   Androstenedione/*analogs & derivatives Aromatase Inhibitors. Steroids 1995 May;60(5):423-7
4-phenylthio-1,4,6-androstatriene-3,17-dione  0   *Androstatrienes *Sulfides Aromatase Inhibitors. Steroids 1995 May;60(5):423-7
4-phenylthioandrosta-4,6-diene-3,17-dione  0   *Sulfides Androstenedione/*analogs & derivatives Aromatase Inhibitors. Steroids 1995 May;60(5):423-7
FCE 27993  0   *Androstadienes Aromatase Inhibitors. J Steroid Biochem Mol Biol 1994 Jun;49(4-6):289-94
MDL 102253  142645-70-3   Androstenedione/*analogs & derivatives Aromatase Inhibitors. J Biol Chem 1994 Jul 29;269(30):19501-8
6-ethylandrost-4-ene-3,17-dione  156264-67-4   Androstenedione/*analogs & derivatives Aromatase Inhibitors. J Med Chem 1994 Apr 29;37(9):1312-9
1-pentyl-3-(4-aminophenyl)pyrrolidine-2,5-dione  0   *Pyrrolidinones Aromatase Inhibitors. J Enzym Inhib 1993;7(2):137-45
LY 43578  26766-35-8 5-Pyrimidinemethanol, alpha,alpha-bis(4-chlorophenyl)  *Pyrimidines Aromatase Inhibitors. Pharmacol Biochem Behav 1994 Jan;47(1):183-6
N-(4-hydroxyundecanoyl)anabasine  133201-45-3 Piperidine, 1-(4-hydroxy-1-oxoundecyl)-2-(3-pyridinyl)  Anabasine/*analogs & derivatives Aromatase Inhibitors. Cancer Lett 1993 Dec 20;75(3):175-82
3-(4'-aminophenyl)pyrrolidine-2,5-dione  32856-49-8   *Aniline Compounds *Succinimides Aromatase Inhibitors. J Enzym Inhib 1993;6(4):317-30
2-N,N-dimethylamino-4,6-bis(1-H-imidazol-1-yl)-1,3,5-triazine  153429-75-5   Altretamine/*analogs & derivatives Aromatase Inhibitors. Anticancer Res 1993 May-Jun;13(3):623-6
Org 33201  148714-92-5 1H-Imidazole, 1-((3a-ethyl-9-(ethylthio)-2,3,3a,4,5,6-hexahydro-1H-phenalen-2-yl)methyl)-, monohydrochloride, (2S-trans)  *Imidazoles *Phenalenes Aromatase Inhibitors. J Steroids Biochem Mol Biol 1993 Mar;44(4-6):681-2
CGP 45688  134520-88-0 Benzonitrile, 4,4'-(2H-tetrazol-2-ylmethylene)bis  *Nitriles *Tetrazoles Aromatase Inhibitors. J Steroid Biochem Mol Biol 1993 Mar;44(4-6):633-6
CGP 47645  143030-47-1 Benzonitrile, 4,4'-(fluoro-1H-1,2,4-triazol-1-ylmethylene)bis  *Nitriles *Triazoles Aromatase Inhibitors. J Steroid Biochem Mol Biol 1993 Mar;44(4-6):421-8
LY 183648  102993-90-8   *Chlorobenzenes *Pyrimidines Aromatase Inhibitors. Cancer Res 1992 Sep 1;52(17):4663-71
2,19-(methyleneoxy)androst-4-ene-3,17-dione  136182-63-3   Androstenedione/*analogs & derivatives Aromatase Inhibitors. J Med Chem 1992 Aug 21;35(17):3303-6
minamestane  105051-87-4   *Androstatrienes Aromatase Inhibitors. J Chromatogr 1992 Feb 28;593(1-2):25-8
3-(4-aminophenyl)-3-cyclohexylpiperidine-2,6-dione  137548-41-5   *Piperidones Aromatase Inhibitors. J Med Chem 1992 Jun 12;35(12):2210-4
N-octanoylnornicotine  38854-10-3   Nicotine/*analogs & derivatives Aromatase Inhibitors. Endocr Res 1991;17(3-4):409-19
10-methylthioethyl estra-4,9(11)-diene 3,17-dione  137437-16-2 Estra-4,9(11)-diene-3,17-dione, 10-(2-(methylthio)ethyl)  *Estrenes Aromatase Inhibitors. J Steroid Biochem Mol Biol 1992 Mar;41(3-8):773-7
19-ethynyl-19-hydroxyandrost-4-en-17-one  135144-30-8   *Androstenols Aromatase Inhibitors. J Med Chem 1991;34(8):2496
19,19-difluoroandrost-4-en-17-one  129400-04-0 Androst-4-en-17-one, 19,19-difluoro  *Androstenes Aromatase Inhibitors. J Med Chem 1991;34(8):2496
4-(2,6-dihydroxybenzoyl)-3-formyl-5-hydroxybenzoic acid  0 Benzoic acid, 4-(2,6-dihydroxybenzoyl)-3-formyl-5-hydroxy  *Hydroxybenzoic Acids Aromatase Inhibitors. J Antibiot (Tokyo) 1991;44(6):589
2,2-dimethyl-4-hydroxy-4-androstene-3,17-dione  132609-68-8   Androstenedione/*analogs & derivatives Aromatase Inhibitors. J Enzym Inhib 1990;4(2):131
3-(cyclohexylmethyl)-1-(4-aminophenyl)-3-azabicyclo(3.1.0)hexane-2,4-dione  133986-32-0   *Aniline Compounds *Bicyclo Compounds, Heterocyclic Aromatase Inhibitors. J Med Chem 1991;34(4):1329
19-(ethyldithio)androst-4-ene-3,17-dione  99957-90-1   Androstenedione/*analogs & derivatives Aromatase Inhibitors. J Steroid Biochem Mol Biol 1991;38(2):181
more...

To share this definition, click "text" (Facebook, Twitter) or "link" (blog, mail) then paste text link
Ads by Google

Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
This website is accredited by Health On the Net Foundation. Click to verify. We comply with the HONcode standard for trustworthy health information: verify here.
About Reference.MD Privacy