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Indicators and Reagents

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Definition: Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)  NIM; coord with specific substance (IM or NIM); D25-26 qualif except /diag use; REAGENT KITS, DIAGNOSTIC & REAGENT STRIPS are also available; DF: INDICATORS   
See Also Chelating Agents; Coloring Agents; Reagent Kits, Diagnostic
Examples Affinity Labels; Chromogenic Compounds; Cross-Linking Reagents; Intercalating Agents; Luminescent Agents; Neuronal Tract-Tracers; Radiopharmaceuticals; Reagent Kits, Diagnostic; Reducing Agents; Sulfhydryl Reagents; Thiobarbituric Acid Reactive Substances
Other names Reagents; Reagents and Indicators; Indicators
Substances having this pharmacologic action: bronopol; 4-N,N-dimethylaminoazobenzene-4'-sulfonyl chloride; 4-dimethylaminocinnamaldehyde; N-(7-dimethylamino-4-methylcoumarinyl)maleimide; Bolton-Hunter reagent; 2-toluidine; cellulose triacetate; 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid; sephadex; 2,3-naphthalenedicarboxaldehyde; bathocuproine sulfonate; 7-amino-4-methylcoumarin; chromium trioxide; 4-vinylpyridine; Folin's phenol reagent; potassium hydroxide; oxonol VI; perfluorobutyric acid; fluorescein dilaurate; tris(2,2'-bipyridine)ruthenium II; trimethylchlorosilane; 3-(2,4-dinitroanilino)-3'-amino-N-methyldipropylamine; Phenolphthalein; 1,2-epoxy-3-(p-nitrophenoxy)propane; morin; 4-(4-nitrobenzyl)pyridine; nitrophenylphosphate; 2-nitro-5-thiocyanobenzoic acid; fluorexon; glyoxal bis(2-hydroxyanil); heptafluorobutyric anhydride; indoleglycerol phosphate; benzoquinone; coomassie Brilliant Blue; safranine T; 4-(dimethylamino)benzaldehyde; 2,2-diphenyl-1-picrylhydrazyl; ferulic acid; acetylcellulose; sodium cyanoborohydride; bathophenanthroline; orcinol; ferroin; syringic acid; bathocuproine; 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid; 4-methylumbelliferyl phosphate; phenyltrimethylammonium; N-ethyl-5-phenylisoxazolium-3'-sulfonate; sulfamic acid; resazurin; picric acid; phosphomolybdic acid; methyl acetimidate; bentiromide; 3-chloroperbenzoic acid; diazobenzenesulfonic acid; Florox Reagent; Ampyrone; Phenylglyoxal; Phloroglucinol; Phosphothreonine; Digitonin; Fluorescamine; Amaranth Dye; Arsenazo III; Aurovertins; Potassium Permanganate; Murexide; 4-Chloro-7-nitrobenzofurazan; Neutral Red; Ninhydrin; Propidium; Rhodamines; Ruthenium Red; Sodium Cyanide; Sodium Nitrite; Sorbitol; Sulfobromophthalein; Tetramethylphenylenediamine; Tetranitromethane; Tetraphenylborate; Tetrathionic Acid; Tetrazolium Salts; Thiocholine; Thiourea; Thymolphthalein; Tuberculin; Nitroblue Tetrazolium; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Tomatine; 2-Hydroxy-5-nitrobenzyl Bromide; 2,2'-Dipyridyl; 2,6-Dichloroindophenol; Nitroprusside; Acetic Acid; Streptavidin; Sodium Azide; Luminol; o-Phthalaldehyde; p-Aminohippuric Acid; Formazans; Guaiac; Dimethyl Adipimidate; Dimethyl Suberimidate; Dimyristoylphosphatidylcholine; Dinitrochlorobenzene; Diphenylcarbazide; Coccidioidin; Cotinine; Coumarins; Biuret; Bromcresol Green; Hymecromone; Bromcresol Purple; Bromphenol Blue; Bromthymol Blue; Imidoesters; Ethidium; Dansyl Compounds; Ferrozine; Phenolphthaleins; Phenolsulfonphthalein; Aminacrine; N-(1-anilinonaphthalyl)-4-maleimide; NAP taurine; nitrocefin; dithiobis(succinimidylpropionate); thiocarbohydrazide; triphenylmethylphosphonium; 1,2-diamino-4-nitrobenzene; 1,3,4,6-tetrachloro-3 alpha,6 alpha-diphenylglycoluril; 4-(N,N-dimethylaminoazobenzene)-4'-isothiocyanate; 3-maleimidobenzoyl N-hydroxysuccinimide; tetraphenylphosphonium; oxonol V; ethyl acetimidate; chrome azurol S; copper phthalocyanine; antipyrylazo III; chloramine-T; (2-sulfonatoethyl)methanethiosulfonate; (2-(trimethylammonium)ethyl)methanethiosulfonate; 4,5-diaminofluorescein; 4,5-diaminofluorescein diacetate; calf thymus DNA; DTPA pentetreotide; chromic phosphate, 32P-labeled; methanethiosulfonate ethylammonium; 2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)acetamide; methyl orange; Capromab Pendetide; 1,2-dioxetane; 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate; tris(2-carboxyethyl)phosphine; brucine; Lipofectamine; digoxigenin-11-deoxyuridine triphosphate; methanethiosulfonate; 3-(2'-spiroadamantane)-4-methoxy-4-(3''-phosphoryloxy)phenyl-1,2-dioxetane; 1-(9-fluorenyl)methyl chloroformate; 2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-5-((phenylamino)carbonyl)-2H-tetrazolium hydroxide; Coomassie blue; fluorescein-dextran; Bolton Hunter-cholecystokinin octapeptide; bicinchoninic acid; N,N-bis(trimethylsilyl)-2,2,2-trifluoroacetamide
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
bis-(2-hydroxy-1-naphthaldimine)-N-diethylene-triamine  0   *Naphthalenes Indicators and Reagents. J AOAC Int. 2009 Jul-Aug;92(4):1203-7
3-methyl-2-benzothiazolinone hydrazine hydrochloride  0   *Hydrazines *Benzothiazoles Indicators and Reagents. Acta Pharm. 2008 Mar;58(1):111-8
hexylchloroformate  0   *Formic Acids Indicators and Reagents. Forensic Sci Int 2007 Sep 13;171(2-3):142-50
MoO2Cl2  0   *Oxides *Chlorine Compounds *Manganese Compounds Indicators and Reagents. Org Lett 2006 Nov 23;8(24):5633-6
1,1,1-triacetoxy-1,1-dihydro-1,2-benziodoxol-3(1H)-one  0   *Hydrocarbons, Iodinated Indicators and Reagents. Angew Chem Int Ed Engl 2005 Sep 19;44(37):5992-7
guaiol  0   *Sesquiterpenes Indicators and Reagents. Planta Med 2002 Oct;68(10):949-50
7-(N,N-dimethylaminosulfonyl)-5-N-(4-N-aminoethyl)piperazino-2,1,3-benzoxadiazole  0   *Oxadiazoles *Piperazines Indicators and Reagents. Analyst 2002 Jun;127(6):741-7
heptakis(2,3-diacetyl-6-sulfo)-cyclodextrin  0   *beta-Cyclodextrins Indicators and Reagents. Electrophoresis 2001 Sep;22(15):3178-84-
1-pentadecyl-4-(4-aminonaphthylazo)pyridinium  0   *Pyridinium Compounds Indicators and Reagents. Anal Sci 2001 Nov;17(11):1335-7
binor S  0   *Polycyclic Hydrocarbons, Aromatic Indicators and Reagents. J Org Chem 2001 Dec 28;66(26):9063-6
divinylbenzene-polystyrene copolymer  0   *Polystyrenes Indicators and Reagents. Org Lett 2001 Jan 25;3(2):307-9
n-fluoroacyl oxazaborolidine  0   *Boron Compounds Indicators and Reagents. Org Lett 2001 Mar 22;3(6):823-6
ethyl(methyl)dioxirane  0   Ethylene Oxide/*analogs & derivatives Indicators and Reagents. Org Lett 2001 Mar 22;3(6):815-8
N,N'-bis(glycine-2- benzimidazolyl)hexanediamide  0   *Amides *Benzimidazoles Indicators and Reagents. Inorg Chem 2001 Feb 26;40(5):878-85
4-(6,7-dihydro-5,8-dioxothiazolo(4,5-g)phthalazin-2-yl)benzoic acid N-hydroxysuccinimide ester  0   *Succinimides *Thiazoles Indicators and Reagents. J Chromatogr A 2001 Jan 12;907(1-2):39-46
4-O-(alpha-carboxy-2-nitrobenzyl)aspartic acid  0   *Phenylacetates Aspartic Acid/*analogs & derivatives Indicators and Reagents. Biochemistry 2001 Jan 9;40(1):232-40
trimethylsilyl iodide  0   *Trimethylsilyl Compounds Indicators and Reagents. Bioorg Med Chem Lett 2000 Oct 16;10(20):2311-3
pentafluorobenzaldehyde  0   *Benzaldehydes Indicators and Reagents. J Agric Food Chem 2000 Aug;48(8):3311-6
alpha,omega-bis(oxiranylmethoxy)poly(ethylene glycol)  0   *Polyethylene Glycols Indicators and Reagents. J Controlled Release 2000 Jul 3;67(2-3):129-39
2',4',6',-trinitrophenyl-2-deoxy-2,2-difluoro-alpha-glycoside  0   *Glycosides *Nitro Compounds Indicators and Reagents. Biochemistry 2000 Aug 15;39(32):9826-36
Lumi-Phos 530  146239-76-1   Organic Chemicals Indicators and Reagents Luminescent Measurements. Biotechniques 1992 Sep;13(3):339-40
kenacid blue  108066-47-3   Organic Chemicals Indicators and Reagents. J Chem Technol Biotechnol 1991;50(3):423
pirfotekh  52997-54-3   Organic Chemicals Indicators and Reagents. Vestn Dermatol Venerol 1989;(10):75
Romanowsky-Giemsa stain  0   *Azure Stains *Eosine Yellowish-(YS) Coloring Agents Indicators and Reagents Staining and Labeling. Histochem J 1985;17(3):263
May-Grunwald Giemsa  0   *Eosine Yellowish-(YS) *Methylene Blue Indicators and Reagents Staining and Labeling.
Pharma Action Coloring Agents
Basic Appl Histochem 1984;28(3):265
Chirasil-Val  0   Organic Chemicals Indicators and Reagents. J Chromatogr 1983;279:507
plastan  0   Organic Chemicals Indicators and Reagents. Clin Lab Haematol 1982;4(1):55
polyhistidine  26062-48-6   *Histidine Histidine Indicators and Reagents. Indian J Biochem Biophys 1981;18(3):233
lumatom  75757-40-3   Organic Chemicals Indicators and Reagents. Environ Anal Chem 1980;8(4):249
Thormahlen reaction  0   Organic Chemicals Indicators and Reagents. J Chromatogr 154(1):117;1978; J Chromatogr 154(1):122;1978
flomols  0   Organic Chemicals Fluorescence Indicators and Reagents Membranes. BBA 471:371;1977
hepaplastin  77536-29-9 Hepaplastin  Organic Chemicals Indicators and Reagents. Jap J Clin Pathol 24(3):229;1976
zaponin  80940-35-8 Zaponin  Organic Chemicals Indicators and Reagents. Prog Reprod Biol I Sperm Action W3 IN887K:36;1975
uriglox  0   Organic Chemicals Indicators and Reagents. Cesk Pediatr 30(5):243;1975; J Pediatr 85(4):514;1974
uricolor 400  0   Organic Chemicals Indicators and Reagents. Med Lab 26(11):264;1973
higonavis  0   Organic Chemicals Gonadotropins/immunology Indicators and Reagents. Clin Endocrinol (Tokyo) 22(4):553;1974; Clin Endocrinol (Tokyo) 23(2):165;1975
urintrol  0   Organic Chemicals Indicators and Reagents Urine/analysis. Am J Clin Pathol 59(2):185;1973
Muco-Lexx  0   Organic Chemicals Indicators and Reagents.
leuteonosticon  49760-92-1 L-Prolinamide, 5-oxo-L-prolyl-L-leucyl  Peptides Indicators and Reagents.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

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