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Sorbitol

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Definition: A polyhydric alcohol with about half the sweetness of sucrose. Sorbitol occurs naturally and is also produced synthetically from glucose. It was formerly used as a diuretic and may still be used as a laxative and in irrigating solutions for some surgical procedures. It is also used in many manufacturing processes, as a pharmaceutical aid, and in several research applications.     
Pharmacological Action Cathartics; Indicators and Reagents; Sweetening Agents
Examples Isosorbide; Meglumine
Other names Glucitol; Sorbitol Pfizer Brand; klysma Sorbit; Trommsdorff Brand of Sorbitol; Sorbilax; Pfizer Brand of Sorbitol; Medevac; Medefield Brand of Sorbitol; Baxter Brand of Sorbitol; YalDrugs* : SORBITOL-MANNITOL IN PLASTIC CONTAINER; SORBITOL-MANNITOL; SORBITOL 3.3% IN PLASTIC CONTAINER; SORBITOL 3% IN PLASTIC CONTAINER
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2-O-galloyl-1,5-anhydroglucitol  0   Sorbitol/*analogs & derivatives. J Enzyme Inhib Med Chem 2011 Apr;26(2):176-80
6-O-galloyl-1,5-anhydroglucitol  0   Sorbitol/*analogs & derivatives. J Enzyme Inhib Med Chem 2011 Apr;26(2):176-80
gentiobiitol  0   Sorbitol/*analogs & derivatives. Phytochemistry. 2010 May;71(7):736-41
1,5-anhydro-1-(5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl)-1-thioglucitol  0   Sorbitol/*analogs & derivatives. J Med Chem 2010 Apr 22;53(8):3247-61
2-deoxy-3-fluorosorbitol  0   Sorbitol/*analogs & derivatives Fluorine Radioisotopes. Mol Imaging Biol 2008 Mar-Apr;10(2):92-8
glucitol-1,6-bis-phosphate  0   *Sugar Phosphates Sorbitol/*analogs & derivatives. Bioorg Med Chem Lett 2008 Mar 1;18(5):1735-7
2,5-dideoxy-2,5-imino-D-glucitol  0   Sorbitol/*analogs & derivatives. Org Lett 2006 Jan 19;8(2):297-9
3-glucopyranosylglucitol  0   *Glucosides Sorbitol/*analogs & derivatives. Carbohydr Res 2004 Oct 4;339(14):2407-14
quinovitol (6-deoxy-glucitol)  0   Sorbitol/*analogs & derivatives. Phytochemistry 2001 Oct;58(4):641-4
2-deoxyglucitol 6-phosphate  0   *Sugar Phosphates Sorbitol/*analogs & derivatives Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing)/antagonists & inhibitors. J Biol Chem 2000 Jan 7;275(1):135-40
N-(glucitol)ethanolamine  0   Sorbitol/*analogs & derivatives. Anal Biochem 1999 Jul 15;272(1):48-55
1-amino-1-deoxy-glucitol  0   Sorbitol/*analogs & derivatives. Carbohydr Res 1998 Dec 21;314(1-2):47-63
2-deoxy-2-aminoglucitol-6-phosphate  0   *Sugar Phosphates Sorbitol/*analogs & derivatives. Structure 1995 Dec 15;3(12):1323-32
1,5-anhydro-2,3,6-tri-O-methylglucitol  0   Sorbitol/*analogs & derivatives. Carbohydr Res 1996 Jan 4;280(1):59-66
1,5-anhydro-2,3,4-tri-O-methylglucitol  0   Sorbitol/*analogs & derivatives. Carbohydr Res 1996 Jan 4;280(1):59-66
dibenzylidene sorbitol  32647-67-9   Sorbitol/*analogs & derivatives. Microsc Res Tech 1995 Aug 1;31(5):467-8
sibirate  152338-47-1 D-Glucitol, 1-(3-(4-hydroxy-3-methoxyphenyl)-2-propenoate), (E)  *Cinnamates Sorbitol/*analogs & derivatives. Yao Hsueh Hsueh Pao 1993;28(10):798-800
sorbitol permease  79955-98-9 Proteins, specific or class, sorbitol-transporting  *Membrane Transport Proteins Sorbitol. Am J Physiol 1994 Feb;266(2 Pt 1):C343-50
3-deoxy-3-fluorosorbitol  34339-82-7   Sorbitol/*analogs & derivatives. J Biol Chem 1994 Jan 28;269(4):2521-8
N-4-isopropylbenzylglucamine dithiocarbamate  111811-14-4   *Thiocarbamates Sorbitol/*analogs & derivatives. Toxicol Appl Pharmacol 1992 Sep;116(1):24-9
tyramine-deoxysorbitol  0   Sorbitol/*analogs & derivatives Tyramine/*analogs & derivatives. Int J Rad Appl Instrum B 1992 Aug;19(6):685-95
Profylin  0   *Sorbitol *Xylitol. Acta Odontol Scand 1991 Oct;49(5):267-72
4-O-acetyl-1,5-anhydro-O-(methoxycarbonylmethyl)di-O-methylglucitol  134121-14-5   Sorbitol/*analogs & derivatives. Carbohydr Res 1991;211(1):47
4-O-acetyl-1,5-anhydro-di-O-(methoxycarbonylmethyl)-O-methylglucitol  134121-16-7   Sorbitol/*analogs & derivatives. Carbohydr Res 1991;211(1):47
4-O-acetyl-1,5-anhydro-2,3,6-tri-O-(methoxycarbonylmethyl)glucitol  134121-19-0   Sorbitol/*analogs & derivatives. Carbohydr Res 1991;211(1):47
N-4-carboxybenzylglucamine dithiocarbamate  127531-18-4   *Thiocarbamates Sorbitol/*analogs & derivatives. Chem Pharm Bull (Tokyo) 1990;38(11):3136
N-4-hydroxymethylbenzylglucamine dithiocarbamate  127531-17-3   *Thiocarbamates Sorbitol/*analogs & derivatives. Chem Pharm Bull (Tokyo) 1990;38(11):3136
Addiphos  0   *Hydroxides *Phosphates *Sorbitol *Sodium Compounds *Potassium Compounds Infant Food. Arch Dis Child 1990;65(4 Spec No):352
MEGA 11  119772-49-5 D-Glucitol, 1-deoxy-1-(methyl(1-oxoundecyl)amino)  Sorbitol/*analogs & derivatives. Acta Crystallogr B 1989;45(Pt4):447
MEGA 8  85316-98-9   Sorbitol/*analogs & derivatives. Acta Crystallogr B 1989;45(Pt 4):447
N-(4-methoxybenzyl)glucamine dithiocarbamate  115459-35-3   *Thiocarbamates Sorbitol/*analogs & derivatives. Toxicology Lett 1989;48(1):105
4-O-acetyl-1,5-anhydro-2,3,6-tri-O-ethylglucitol  119554-98-2   *Ethyl Ethers Sorbitol/*analogs & derivatives. Carbohydr Res 1988;182(1):53
PAGGS-sorbitol solution  0   *Sorbitol Adenine Glucose Guanosine Phosphates Sodium Chloride Blood Preservation. Vox Sang 1987;52(4):301
permethylsorbitol  20746-36-5   Sorbitol/*analogs & derivatives. Anal Chem 1986;58(8):1670
emtobil  102524-60-7 D-Glucitol, mixt. with peanut oil  *Plant Oils *Sorbitol Drug Combinations. Scand J Gastroenterol 1986;21(2):235
N-benzylglucamine dithiocarbamate  110771-92-1   *Thiocarbamates Sorbitol/*analogs & derivatives.
Pharma Action Chelating Agents
Toxicol Appl Pharmacol 1986;83(3):516
6-deoxyglucitol  5624-40-8   Sorbitol/*analogs & derivatives. J Chromatogr 1984;336(2):345
Pluritene  0   *Amino Acids *Sorbitol. JPEN 1984;8(5):511
N-methyl-D-glucamine dithiocarbamate  91840-27-6 D-Glucitol, 1-deoxy-1-((dithiocarboxy)methylamino)-, monosodium salt  *Thiocarbamates Sorbitol/*analogs & derivatives Spin Labels.
Pharma Action Iron Chelating Agents
Acta Pharmacol Toxicol (Copenh) 1984;54(3):189
sorbamine  89964-48-7 L-Histidine, monohydrochloride, mixt. with L-arginine monohydrochloride, D-glucitol, L-lysine monohydrochloride and potassium chloride (KCl)  *Amino Acids *Sorbitol Drug Combinations Alkalosis/drug therapy. Biull Eksp Biol Med 1984;97(2):152
6-chloro-6-deoxyglucitol  76986-26-0   Sorbitol/*analogs & derivatives. J Reprod Fertil 1982;65(1):177
saliment  0   *Carboxymethylcellulose Sodium *Glycerol *Sorbitol Drug Combinations Saliva, Artificial. Scand J Dent Res 1982;90(2):157
Flatugel A  77321-51-8 Benzoic acid, 4-amino-, ethyl ester, mixt. with aluminum hydroxide (Al(OH)3), magnesium hydroxide (Mg(OH)2) and Me siloxanes  *Aluminum Hydroxide *Benzocaine *Magnesium Hydroxide *Siloxanes *Sorbitol Drug Combinations. Vutr Boles 1980;19(2):60
aluminum hydroxide, magnesium hydroxide, methylpolysiloxane, sorbitol drug combination  77321-50-7 Aluminum hydroxide, mixt. with magnesium hydroxide (Mg(OH)2) and Me siloxanes  *Aluminum Hydroxide *Magnesium Hydroxide *Siloxanes *Sorbitol Drug Combinations. Vutr Boles 1980;19(2):60
aluminum hydroxide, benzocaine, magnesium hydroxide, sorbitol drug combination  0   *Aluminum Hydroxide *Benzocaine *Magnesium Hydroxide *Sorbitol Drug Combinations. Vutr Boles 1980;19(2):60
aluminum hydroxide, magnesium hydroxide, sorbitol drug combination  0   *Aluminum Hydroxide *Magnesium Hydroxide *Sorbitol Drug Combinations. Vutr Boles 1980;19(2):60
Trodax  27917-82-4   *Nitrophenols *Sorbitol Drug Combinations. Indian Vet J 1979;56(10):834
2,4-monofurfurylidene-tetra-O-methylsorbitol  26691-06-5 2,4-O-(2-furanylmethylene)-1,3,5,6-tetra- O-methyl-D-glucitol  Sorbitol/*analogs & derivatives. Arzneim Forsch 29(3):527;1979; Arzneimforsch 1979;29(12):1885
sodium-potassium-magnesium-aspartate-sorbitol  0   *Aspartic Acid *Sorbitol Drug Combinations. Langenbecks Archiv Chir Suppl:30;1979
glycerosorbitol  54578-97-1 D-glucitol mixt. with 1,2,3-propanetriol  *Glycerol *Sorbitol Drug Combinations. Klin Oczna 48(12):659;1978
glucitol hexanicotinate  6184-06-1   *Nicotinic Acids Sorbitol/*analogs & derivatives. Farmaco (Prat) 33(4):162;1978; Pharmacol Res Commun 10(2):127;1978; Pharmacol Res Commun 9(6):599;1977
2-deoxy-2-fluoro-D-glucitol  34339-80-5 D-Glucitol, 2-deoxy-2-fluoro  Sorbitol/*analogs & derivatives. Folia Microbiol 22(4):295;1977
thiobiline  0   *Sorbitol *Thiazolidines Drug Combinations. Sem Hop Ther 52(2):93;1976
Lipofundin  11096-66-5   *Phospholipids *Sorbitol Drug Combinations Fat Emulsions, Intravenous. Probl Gematol Pereliv Krovi 17(9):27;1972
linolenoyl sorbitol  36250-94-9 D-Glucitol, mono-9,12,15-octadecatrienoate, (Z,Z,Z)  Sorbitol/*analogs & derivatives. Brit J Haematol 25(4):429;1973
iron sorbitex  1338-16-5 D-glucitol, iron salt, mixt. with 2-hydroxy- 1,2,3-propanetricarboxylic acid iron salt  *Ferric Compounds *Sorbitol *Citric Acid Drug Combinations. Bull Soc Med Afr Noire Lang Fr 19(2):121;1974
Cardioplegin  68245-15-8 Magnesate(2-), bis(L-aspartato(2-)-N,O1)-, (T-4)-, dihydrogen, mixt. with 2-(diethylamino)ethyl 4-aminobenzoate monohydrochloride  Aspartic Acid Procaine Sorbitol Cardioplegic Solutions. J Cardiovasc Surg 19(2):193;1978; Kard Pol 16(4):299;1973; Khirurgiia(Sofia) 1979;32(4):290; Langenbecks Arch Chir suppl 1979;p.29; Langenbecks Arch Chir:99;1978
1,5-anhydro-2-deoxy-D-glucitol  13035-11-5 D-arabino-Hexitol, 1,5-anhydro-2-deoxy  Sorbitol/*analogs & derivatives. Biochim Biophys Acta 373(3):397;1974
Solcoray  79215-55-7 Solcoray  *Pectins *Sorbitol *Uronic Acids Drug Combinations. Eur J Clin Pharmacol 4(1):38;1972

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

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