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Polyethylene Glycols

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Definition: Polymers of ETHYLENE OXIDE and water, and their ethers. They vary in consistency from liquid to solid depending on the molecular weight indicated by a number following the name. They are used as SURFACTANTS, dispersing agents, solvents, ointment and suppository bases, vehicles, and tablet excipients. Some specific groups are NONOXYNOLS, OCTOXYNOLS, and POLOXAMERS.     
Pharmacological Action Drug Carriers; Solvents; Surface-Active Agents
Examples Cetomacrogol; Hydrogel; Nonoxynol; Octoxynol; Poloxalene; Poloxamer; Polyhydroxyethyl Methacrylate; Polysorbates 		Other names Tritons; Polyoxyethylenes; Macrogols; Polyoxyethylene; Polyethyleneoxides; Polyethylene Oxides; PEO 400; Oxides, Polyethylene; Oxide, Polyethylene; Miralaxs; Macrogol; Lauromacrogol; Glycols, Polyethylene; Glycol, Polyethylene; Glycol 6000, Polyethylene; Glycol 4000, Polyethylene; Glycol 400, Polyethylene; Glycol 2000, Polyethylene; Carbowax400; Carbowax 400Drugs* : PEG-LYTE; TRILYTE; COLYTE-FLAVORED; E-Z-EM PREP LYTE; GLYCOLAX; COLYTE WITH FLAVOR PACKS; POLYETHYLENE GLYCOL 3350; COLOVAGE
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
pentaethylenehexamine-end poly(ethylene glycol)  0   *Polyethylene Glycols. Colloids Surf B Biointerfaces. 2012 Apr 1;92:25-9.
(NP(PEG750)(GlyPheLeu)2Et)3  0   *Peptides *Polyethylene Glycols Drug Carriers. Int J Pharm. 2012 Jan 17;422(1-2):374-80.
poly(ethylene glycol)-poly(N'-(N-(2-aminoethyl)-2-aminoethyl)aspartamide) block copolymer  0   *Polyethylene Glycols *Proteins Gene Transfer Techniques. J Control Release. 2011 Oct 30;155(2):296-302.
PEG-IFN-SA  0   *Polyethylene Glycols *Interferon-alpha. Regul Pept. 2012 Jan 10;173(1-3):74-81.
monomethoxypolyethyleneglycol-cholesteryl ester  0   *Cholesterol Esters *Polyethylene Glycols Drug Carriers. AAPS PharmSciTech. 2011 Dec;12(4):1056-63.
DuraSeal spinal sealant  0   *Oligopeptides *Polyethylene Glycols Drug Combinations. Spine (Phila Pa 1976). 2011 Nov 1;36(23):1906-12.
PEG-poly(hexamethylene-urethane)  0   *Polyethylene Glycols *Polyurethanes. Molecules. 2011;16(10) (dup#14):8181-97
oligo(trimethylene carbonate)-block-poly(ethylene glycol)-block-oligo(trimethylene carbonate) diacrylate  0   *Polyesters *Polyethylene Glycols. Acta Biomater. 2011 Sep;7(9):3362-9.
poly(ethylene glycol)-block-poly(propylene sulfide)-block-poly(ethylene imine)  0   *Polyethylene Glycols *Sulfides Polyethyleneimine/*analogs & derivatives Drug Carriers Gene Transfer Techniques. Biomaterials. 2011 Dec;32(36):9839.
star poly(ethylene glycol)hydrazide-prednisolone-20-hydrazone  0   *Polyethylene Glycols Prednisolone/*analogs & derivatives Drug Carriers. Int J Pharm. 2011 Jul 29;414(1-2):42-7.
folate-poly(ethylene glycol)-grafted-trimethyl chitosan  0   *Polyethylene Glycols Chitosan/*analogs & derivatives Drug Carriers. J Drug Target. 2011 Sep;19(8):647-56.
methoxy poly(ethylene glycol)-b-poly(2-hydroxyethyl methacrylate)-co-histidine-poly(lactide)  0   *Polyethylene Glycols *Polymethacrylic Acids Drug Carriers. J Control Release. 2011 Aug 25;154(1):84-92.
polyethylene glycol-recombinant human growth hormone  0   *Polyethylene Glycols Human Growth Hormone/*analogs & derivatives. Yao Xue Xue Bao 2009 May;44(5):506-9
methoxy poly(ethylene glycol)-block-poly(lactic acid)  0   *Polyesters *Polyethylene Glycols Drug Carriers. Cancer Chemother Pharmacol 2011 Aug;68(2):431-44
octaoxyethylene-laurate ester  0   *Laurates *Polyethylene Glycols. Int J Pharm 2011 Jun 30;412(1-2):142-7
poly(ethylene glycol)-poly(N-acryloyl-2,2-dimethyl-1,3-oxazolidine) block copolymer  0   *Acrylic Resins *Polyethylene Glycols. J Phys Chem B. 2011 May 19;115(19):5913-22
poly(propylene oxide)-block-poly(ethylene oxide)-block-poly(propylene oxide)  0   *Polyethylene Glycols *Propylene Glycols. Macromol Biosci 2011 May 12;11(5):590-4
poly(ethylene glycol)-block-poly(2-methyl-2-benzoxycarbonyl-propylene carbonate)  0   *Polyethylene Glycols *Polypropylenes. J Pharm Sci. 2011 Jun;100(6):2418-29
poly(ethoxytriethyleneglycol acrylate)  0   *Acrylic Resins *Polyethylene Glycols Drug Carriers. J Control Release 2010 Nov 20;148(1):e81-2
polyoxyethylene(25)dodecyl ether  0   *Polyethylene Glycols. Int J Pharm 2011 Mar 15;406(1-2):173-8
methoxypolyethyleneglycol-poly(lactic-co-glycolic acid)  0   *Polyesters *Polyethylene Glycols Biocompatible Materials. Int Urogynecol J Pelvic Floor Dysfunct 2011 Feb;22(2):191-6
NNC126-0083  0   *Polyethylene Glycols Human Growth Hormone/*analogs & derivatives. J Clin Endocrinol Metab 2011 Mar;96(3):681-8
didecyl methyl polyoxyethyl ammonium  0   *Quaternary Ammonium Compounds *Polyethylene Glycols. Contact Dermatitis 2009 May;60(5):296-8
(poly(epsilon-benzyloxycarbonyllysine))2-block-poly(ethylene glycol)-block-(poly(epsilon-benzyloxycarbonyllysine))2  0   *Polyethylene Glycols Polylysine/*analogs & derivatives. Macromol Biosci 2011 Jan 10;11(1):65-71
alginate-polyethylene glycol acrylate  0   *Alginates *Polyethylene Glycols. Acta Biomater 2011 Feb;7(2):625-33
methoxypolyethylene glycol-succinimidyl-propionic acid ester  0   *Polyethylene Glycols. Int J Hematol 2010 Nov;92(4):609-16
poly(ethylene glycol)-block-poly(2-methyl-2-carboxylpropylene carbonate-graft-dodecanol)  0   *Polyesters *Polyethylene Glycols Drug Carriers. Biomacromolecules 2010 Oct 11;11(10):2610-20
NC 6300  0   *Proteins Epirubicin/*analogs & derivatives Polyethylene Glycols. Cancer Sci 2011 Jan;102(1):192-9
methoxy poly(ethylene glycol)-b-poly(caprolactone)-b-poly(2-dimethylaminoethyl methacrylate)  0   *Quaternary Ammonium Compounds *Polyethylene Glycols. Biomacromolecules 2010 Sep 13;11(9):2306-12
polysuccinimide-graft-polyethylenimine-graft-poly(ethylene glycol)  0   *Polyethylene Glycols *Polyethyleneimine. Acta Biomater 2010 Nov;6(11):4285-95
poly(citric acid)-block-poly(ethylene glycol)-block-poly(citric acid)  0   *Polyesters *Polyethylene Glycols. Nanomedicine 2010 Aug;6(4):556-62
poly(ethylene glycol)-b-poly(gamma-methyl-epsilon-caprolactone)  0   *Polyesters *Polyethylene Glycols. J Colloid Interface Sci 2010 Nov 1;351(1):140-50
octanoylchitosan-polyethylene glycol monomethyl ether  0   *Polyethylene Glycols Chitosan/*analogs & derivatives. J Phys Chem B 2010 Jun 17;114(23):7719-26
poly(ethylene glycol)-folate  0   *Polyethylene Glycols Folic Acid/*analogs & derivatives. J Colloid Interface Sci 2010 Aug 15;348(2):360-8
poly(ethylene oxide)-b-poly(alpha-cholesteryl carboxylate-epsilon-caprolactone) block copolymer  0   *Polyethylene Glycols *Polyesters. Biomacromolecules 2009 Mar 9;10(3):471-8
polyoxyethylene (23) dodecylether  0   *Polyethylene Glycols. Int J Pharm 2010 Jul 15;394(1-2):174-8
PEGylated tumor necrosis factor-related apoptosis-inducing ligand  0   *Polyethylene Glycols *Recombinant Fusion Proteins. Mol Cancer Ther 2010 Jun;9(6):1719-29
Mal-PL-sCT  0   *Calcitonin *Polyethylene Glycols. J Pharm Pharmacol. 2010 Mar;62(3):296-304
2PEG-Mal-sCT  0   *Polyethylene Glycols Calcitonin. J Pharm Pharmacol. 2010 Mar;62(3):296-304
poly(2-hydroxyethyl methacrylate)-g-(poly(ethylenimine)-b-poly(ethylene glycol))  0   *Polyethylene Glycols Polyhydroxyethyl Methacrylate/*analogs & derivatives Polyethyleneimine. Int J Pharm 2010 Jun 15;392(1-2):118-26
triton X-165  0   *Benzene Derivatives *Polyethylene Glycols. Langmuir 2010 Feb 2;26(3):1860-9
poly(ethylene oxide)-block-poly(gamma-methacryloxypropyltrimethoxysilane)  0   *Methacrylates *Polyethylene Glycols. Biomaterials 2010 Jul;31(20):5397-407
polyethylene glycol monooctylphenyl ether  0   *Polyethylene Glycols Polymers. Langmuir. 2010 May 18;26(10):6982-8
poly(monomethylnona(ethylene glycol) 1-methylene-3-(4-methylphenyl)-1H-indene-2-carboxylate)  0   *Indenes *Polyethylene Glycols. Int J Pharm 2010 May 10;390(2):183-90
polyethylene glycol-block-poly(aminoethyl methacrylate)  0   *Acrylic Resins *Polyethylene Glycols. J Control Release 2010 Mar 3;142(2):229-37
S-(2,3-bispalmitoyloxypropyl)-cysteinyl-amido-monomethoxyl polyethylene glycol  0   *Polyethylene Glycols *Lipopeptides. Eur J Immunol 2010 May;40(5):1272-83
mono-PEGylated Endostar  0   *Polyethylene Glycols *Endostatins. Int J Biol Macromol 2010 apr 1;46(3):331-6
poly(itaconic acid-graft-ethylene glycol)  0   *Polyethylene Glycols *Succinates. J Biomed Mater Res A 2010 Apr;93(1):175-88
poly(2-(2-methoxyethoxy)ethyl methacrylate-co-oligo(ethylene glycol) methacrylate)  0   *Methacrylates *Polyethylene Glycols. Langmuir. 2010 Mar 2;26(5):3462-7
poly(poly(ethylene glycol)methyl ether methacrylate)-block-poly(pentafluorostyrene)  0   *Polyethylene Glycols *Polystyrenes. Langmuir. 2010 Feb 16;26(4):2361-8
polyoxyethylene 32 distearate  0   *Polyethylene Glycols. J Pharm Sci 2010 Mar;99(3):1399-413
poly(ethylene oxide)-b-poly(methacrylic acid)  0   *Polyethylene Glycols *Polymethacrylic Acids. J Pharm Sci. 2010 Feb;99(2):782-93
1-(2-tryptanthrinylaminoacetoxy)-14-(1-pyrenecarboxy)-3,6,9,12-tetraoxatetradecane  0   *Polyethylene Glycols *Pyrenes. Anal Sci 2009 Dec;25(12):1385-6
four-arm poly(ethylene oxide)-b-poly(2-(diethylamino)ethyl methacrylate)  0   *Polyethylene Glycols *Polymethacrylic Acids. J Biomed Mater Res A 2009 Dec;91(3):708-18
poly(ethylene oxide)-b-poly(alpha-benzyl carboxylate epsilon-caprolactone)  0   *Polyesters *Polyethylene Glycols. Biomaterials 2010 Jan;31(2):345-57
poly(ethylene glycol)-block-poly(4-vinylpyridine)  0   *Polyethylene Glycols *Polyvinyls. Biomacromolecules 2009 Dec 14;10(12):3341-2
alpha-biotin polyethylene glycol-b-poly(pyridyldisulfide ethylmethacrylate)  0   *Polyethylene Glycols *Polymethacrylic Acids. Biomacromolecules 2009 Dec 14;10(12):3253-8
omega-amido-(Nalpha-palmitoyloxy-S-(2,3-bis(palmitoyloxy)propyl)cysteinyl)-alpha-amino poly(ethylene glycol)  0   *Polyethylene Glycols Cysteine/*analogs & derivatives Toll-Like Receptor 2/agonists. Int J Pharm 2009 Nov 3;381(2):97-105
poly(1,8-bis(4-carboxyphenoxy)-3,6-dioxaoctane)  0   *Polyethylene Glycols *Polyanhydrides. J Biomed Mater Res B Appl Biomater 2009 Nov;91(2):938-47
alpha-tocopherol succinyl dodecaethylene glycol  0   *Polyethylene Glycols alpha-Tocopherol/*analogs & derivatives. Biochem Pharmacol 2009 Dec 15;78(12):1464-74
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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