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Surface-Active Agents

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Definition: Agents that modify interfacial tension of water; usually substances that have one lipophilic and one hydrophilic group in the molecule; includes soaps, detergents, emulsifiers, dispersing and wetting agents, and several groups of antiseptics.     
See Also Pulmonary Surfactants
Examples Antifoaming Agents; Detergents; Emulsifying Agents; Immunosorbents; Wetting Agents 		Other names Surfactants; Agents, Surface-Active; Agents, Surface Active; Agents, Amphiphilic; Active Agents, Surface; Tensides; Surface Active Agents; Amphiphilic Agents
Substances having this pharmacologic action: sorbitan monooleate; monolaurin; dodecyltrimethylammonium; polyethoxylated castor oil; dodecyl sulfate; alkylbenzyl sulfonic acid; dodecylamine; cetrimonium; NPG-GMA; dodecylbenzenesulfonic acid; polyornithine; Poloxamer; Ethonium; tetradecyltrimethylammonium; Lecithins; cremophor EL; Poloxalene; Polyethylene Glycols; Cetomacrogol; Polysorbates; Sodium Dodecyl Sulfate; Sodium Tetradecyl Sulfate; Nonoxynol; Octoxynol; Dioctyl Sulfosuccinic Acid; Iodophors; cetalkonium chloride; tetronic 701; cethexonium; decyltrimethylammonium; dodecyldimethylamine oxide; dimethyldioctadecylammonium; tyloxapol; 4-tert-octylphenol; cocamidopropyl betaine; MF59 oil emulsion; delmopinol
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
lacmoid  0   *Oxazines Surface-Active Agents.
octylododecyl xyloside  0   *Glycosides Allergens Surface-Active Agents. Contact Dermatitis. 2011 Nov;65(5):302-4
butanediyl-1,4-bis(dimethylcetylammonium bromide)  0   *Quaternary Ammonium Compounds Surface-Active Agents. J Colloid Interface Sci. 2011 Jul 15;359(2):467-73
cocamidopropylamine oxide  0   *Oxides *Propylamines Surface-Active Agents. Int J Toxicol. 2008;27 Suppl 1():55-62
peg-8 distearate  0   *Polyethylene Glycols *Stearates Surface-Active Agents. J Pharm Sci 2007 Sep;96(9):2436-45
1,3,5-tris(10-carboxydecyloxy-benzene)  0   *Benzene Derivatives Surface-Active Agents. J Am Chem Soc 2007 Aug 1;129(30):9268-9
annulene gemini surfactant A  0   *Alkenes *Pyridinium Compounds Surface-Active Agents. Angew Chem Int Ed Engl 2007;46(31):5889-91
annulene gemini surfactant C  0   *Alkenes *Pyridinium Compounds Surface-Active Agents. Angew Chem Int Ed Engl 2007;46(31):5889-91
annulene gemini surfactant B  0   *Alkenes *Pyridinium Compounds Surface-Active Agents. Angew Chem Int Ed Engl. 2007;46(31):5889-91
Sanonic SS-90  0   *Polyethylene Glycols Surface-Active Agents. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2004;39(11-12):2867-81
polyethylene glycol-6 sorbitan beeswax  0   *Waxes *Polyethylene Glycols Cosmetics Surface-Active Agents. Int J Toxicol 2001;20 Suppl 4:27-38
polyethylene glycol-8 sorbitan beeswax  0   *Waxes *Polyethylene Glycols Cosmetics Surface-Active Agents. Int J Toxicol 2001;20 Suppl 4:27038
polyethylene glycol-20 sorbitan beeswax  0   *Waxes *Polyethylene Glycols Cosmetics Surface-Active Agents. Int J Toxicol 2001;20 Suppl 4:27-38
2,3-dimethoxy-1,4-bis(N-hexadecyl-N,N-dimethylammonium)butane  0   *Quaternary Ammonium Compounds Surface-Active Agents. Biophys J 2001 Oct;81(4):2135-43
Abil WE 09  0   *Siloxanes Surface-Active Agents. Farmaco 2000 Sep-Oct;55(9-10):583-9
Abil B 8843  0   *Siloxanes Surface-Active Agents. Farmaco 2000 Sep-Oct;55(9-10):583-9
fluorad FC134  0   *Hydrocarbons, Fluorinated Surface-Active Agents. Electrophoresis 2001;22(4):660-5
3-(N-dodecanoyl-L-valylamino)-propyltrimethylammonium bromide  0   *Quaternary Ammonium Compounds *Lipids Surface-Active Agents. Electrophoresis 2001 Jan;22(1):88-96
3-(N-10-undecenoyl-L-valyl)aminopropyl trimethylammonium bromide  0   *Lipids *Quaternary Ammonium Compounds Surface-Active Agents. Electrophoresis 2001 Jan;22(1):88-96
6-(N-nonanoyl-L-valylamino)-propyltrimethylammonium bromide  0   *Quaternary Ammonium Compounds *Lipids Surface-Active Agents. Electrophoresis 2001 Jan;22(1):88-96
cyclohexyl-pentyl-maltoside  0   *Glucosides Surface-Active Agents. Electrophoresis 1999 Sep;20(13):2766-71
poly(undecanoylvalinate)  0   *Biopolymers *Peptides Surface-Active Agents. Anal Chem 1999 Sep 15;71(18):3992-9
F108-NTA, pluronic  0   Nitrilotriacetic Acid/*analogs & derivatives Surface-Active Agents. Biochemistry 1999 Apr 20;38(16):5076-81
Persil  0   Lipids *Peptide Hydrolases *Polyphosphates Surface-Active Agents. Int Endod J 1993 Nov;26(6):334-43
diproxamine  39289-02-6   *Lipids Surface-Active Agents. Vrach Delo 1992 Jul;(7):71-4
Zonyl  67479-85-0   Organic Chemicals Surface-Active Agents. Caries Res 1983;17(4):304
BP 1100X  39403-84-4   *Lipids Surface-Active Agents. Bull Environ Contam Toxicol 1980;25(2):234
novosept  37209-47-5   *Lipids Surface-Active Agents. Vestn Khir 1980;124(2):90
corexit 9527  60617-06-3   *Lipids Surface-Active Agents. Bull Environ Contam Toxicol 23(5-6):661;1979
fabric softeners  0   Organic Chemicals Surface-Active Agents. Int J Dermatol 15(4):297;1976; Jap J Hyg 30(1):234;1975
surfactin peptide  24730-31-2   *Peptides, Cyclic *Lipopeptides Phospholipases A/antagonists & inhibitors Surface-Active Agents.
Pharma Action Antibiotics, Antineoplastic ; Antiviral Agents ; Enzyme Inhibitors 		Chem Pharm Bull (Tokyo) 22(4):938;1974

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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