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Phospholipases A

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Definition: Phospholipases that hydrolyze one of the acyl groups of phosphoglycerides or glycerophosphatidates.  general; prefer specifics   
Examples Phospholipases A1; Phospholipases A2 		Other names A, Phospholipases
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Ldh1 protein, S cerevisiae  EC 3.1.1.-   *Phospholipases A *Saccharomyces cerevisiae Proteins. Eukaryot Cell. 2011 Jun;10(6):770-5
DONGLE protein, Arabidopsis  EC 3.1.1.-   *Phospholipases A *Arabidopsis Proteins. Plant Physiol 2010 May;153(1):114-27
petrosaspongiolide R  0   Oleanolic Acid/*analogs & derivatives Phospholipases A/antagonists & inhibitors. Bioorg Chem 2009 Feb;37(1):6-10
Lpx1 protein, S cerevisiae  EC 3.1.1.-   *Phospholipases A *Saccharomyces cerevisiae Proteins. FEBS J 2008 Feb;275(3):504-14
Cdr-13 protein, Crotalus durissus ruruima  EC 3.1.1.4   *Crotalid Venoms *Phospholipases A. Protein J 2007 Jan;26(1):39-49
Cdr-12 protein, Crotalus durissus ruruima  EC 3.1.1.4   *Crotalid Venoms *Phospholipases A. Protein J 2007 Jan;26(1):39-49
ecopladib  0   *Sulfonamides *Benzoic Acids Phospholipases A/antagonists & inhibitors. J Med Chem 2007 Mar 22;50(6):1380-400
Api m 1 allergen, Apis mellifera  EC 3.1.1.4   *Allergens *Phospholipases A *Insect Proteins Bee Venoms. J Allergy Clin Immunol 2005 Feb;115(2):323-9
6-methyl-4-((2-oxopentadecanoyl)amino)heptanoic acid  0   *Amides *Heptanoic Acids Phospholipases A/antagonists & inhibitors. J Med Chem 2004 Jul 1;47(14):3615-28
4-((2-oxododecanoyl)amino)octanoic acid  0   *Amides *Octanoic Acids Phospholipases A/antagonists & inhibitors. J Med Chem 2004 Jul 1;47(14):3615-28
4-((2-oxohexadecanoyl)amino)butanoic acid  0   *Amides *Butyric Acids Phospholipases A/antagonists & inhibitors. J Med Chem 2004 Jul 1;47(14):3615-28
AT1G67750 protein, Arabidopsis  EC 4.2.2.2   *Phospholipases A *Polysaccharide-Lyases *Arabidopsis Proteins. Plant Physiol 2002 Sep;130(1):90-101
P-PB.III peptide  0   *Oligopeptides Phospholipases A/antagonists & inhibitors. Eur J Biochem 2002 Jan;269(2):719-27
euplexide G  0   *Glycosides *Hydroquinones Phospholipases A/antagonists & inhibitors. Nat Prod Lett 2001;15(2):81-7
euplexide F  0   *Glycosides *Hydroquinones Phospholipases A/antagonists & inhibitors. Nat Prod Lett 2001;15(2):81-7
3-dodecanoylindole-2-carboxylic acid  0   *Indoles Phospholipases A. Bioorg Med Chem Lett 2001 Oct 8;11(19):2569-72
dysidenone B  0   *Sesquiterpenes Phospholipases A/antagonists & inhibitors. J Nat Prod 2001 May;64(5):612-5
dysidine  0   *Sesquiterpenes Phospholipases A/antagonists & inhibitors. J Nat Prod 2001 May;64(5):612-5
dysidenone A  0   *Sesquiterpenes Phospholipases A/antagonists & inhibitors. J Nat Prod 2001 May;64(5):612-5
BMS 229724  0   *Chlorobenzenes *Sulfones Phospholipases A/antagonists & inhibitors. J Pharmacol Exp Ther 2001 Jul;298(1):376-85
2-nitrobenzenesulfonyl fluoride  0   *Nitrobenzenes Phospholipases A. Arch Biochem Biophys 2001 Mar 15;387(2):188-96
MiPLA-4 protein, Micropechis ikaheka  EC 3.1.1.-   *Elapid Venoms *Phospholipases A. Biochim Biophys Acta 2001 Feb 9;1545(1-2):30-40
ceratospongamide  0   *Peptides, Cyclic Phospholipases A/antagonists & inhibitors. J Org Chem 2000 Jan 28;65(2):419-25
12-deacetyl-23-acetoxy-20-methylscalaradial  0   *Sterols Phospholipases A/antagonists & inhibitors. J Nat Prod 2000 Apr;63(4):527-30
MIP-II protein, Cerrophidion godmani  0   *Glycoproteins Phospholipases A/antagonists & inhibitors. Biochem J 2000 Mar 15;346( Pt 3):631-9
MIP-I protein, Cerrophidion godmani  0   *Glycoproteins Phospholipases A/antagonists & inhibitors. Biochem J 2000 Mar 15;346( Pt 3):631-9
BM 16.2266  0   *Acetic Acids *Benzopyrans Phospholipases A/antagonists & inhibitors. Adv Exp Med Biol 1999;469:199-207
NaI protein, Notechis ater  0   *Glycoproteins *Snake Venoms Phospholipases A/antagonists & inhibitors. J Biol Chem 2000 Jan 14;275(2):983-91
bilobetin  0   *Flavonoids Phospholipases A/antagonists & inhibitors Ginkgo biloba. Shock 1999 Dec;12(6):473-8
PLIalpha  0   *Blood Proteins Glycoproteins Phospholipases A/antagonists & inhibitors. Biochim Biophys Acta 1999 Oct 18;1441(1):51-60
indoxam  0   *Carbamates *Indolizines Phospholipases A/antagonists & inhibitors. Biochim Biophys Acta 1999 May 18;1438(2):213-22
LsPLIgamma-B protein, Laticauda semifasciata  0   *Glycoproteins Phospholipases A/antagonists & inhibitors. J Biochem (Tokyo) 1999 Feb;125(2):375-82
LsPLIgamma-A protein, Laticauda semifasciata  0   *Glycoproteins Phospholipases A/antagonists & inhibitors. J Biochem (Tokyo) 1999 Feb;125(2):375-82
1-nitrophenyl-octylphosphonate-2-tridecylcarbamoyl-3-ethanesulfonylamino-3-deoxyglycerol  0   *Phospholipids Phospholipases A/antagonists & inhibitors. Eur J Biochem 1999 Mar;260(3):794-800
SB 222657  0   *Azetidines *Sulfoxides Phospholipases A/antagonists & inhibitors. Biochem J 1999 Mar 1;338( Pt 2):479-87
petrosaspongiolide m  0   Oleanolic Acid/*analogs & derivatives Phospholipases A/antagonists & inhibitors. J Pharmacol Exp Ther 1999 Apr;289(1):166-72
varespladib  0   *Acetic Acids *Indoles Phospholipases A/antagonists & inhibitors. J Pharm Exp Ther 1999 Mar;288(3):1117-24
1-decyl 2-octyl-glycerophosphocholine  0   Glycerylphosphorylcholine/*analogs & derivatives Phospholipases A/antagonists & inhibitors. Fundam Clin Pharmacol 1998;12(4):433-41
EPACOCF3  0   Eicosapentaenoic Acid/*analogs & derivatives Phospholipases A/antagonists & inhibitors. J Immunol 1998 Oct 1;161(7):3421-30
myotoxin II, Bothrops moojeni  EC 3.1.1.-   *Phospholipases A Crotalid Venoms. Toxicon 1998 Mar;36(3):503-14
PLIbeta protein, Agkistrodon blomhoffii siniticus  0   *Blood Proteins Phospholipases A/antagonists & inhibitors. J Biol Chem 1998 Jul 31;273(31):19469-75
SB-216477  0   *Azetidines *Lactams Phospholipases A/antagonists & inhibitors. Biochemistry 1998 Jul 14;37(28):10087-93
indolizine inhibitor 120-1032  0   *Indolizines Phospholipases A/antagonists & inhibitors. J Biochem (Tokyo) 1998 Apr;123(4):619-23
penidiamide  0   *Anthranilic Acids Glycine/*analogs & derivatives Phospholipases A/antagonists & inhibitors. Z Naturforsch (C) 1998 Jan-Feb;53(1-2):60-4
zanhasaponin B  0   *Saponins *Triterpenes Phospholipases A/antagonists & inhibitors. J Nat Prod 1997 Nov;60(11):1158-60
zanhasaponin A  0   *Saponins *Triterpenes Phospholipases A/antagonists & inhibitors. J Nat Prod 1997 Nov;60(11):1158-60
1-dodecyl-2-octanamido-sn-2-deoxyglycero-3-phosphocholine  0   *Phospholipid Ethers Phospholipases A/antagonists & inhibitors. J Enzyme Inhib 1997 Aug;12(3):227-40
GPLI-I protein, Trimeresurus flavoviridis  0   *Blood Proteins Phospholipases A/antagonists & inhibitors. Eur J Biochem 1997 Nov;249(3):838-45
palmitoyl trifluoromethyl ketone  0   *Ketones Phospholipases A/antagonists & inhibitors. Adv Exp Med Biol 1997;407:99-103
6-(1-bromoethylene)tetrahydro-3-(1-naphthenyl)-2H-pyran-2-one  0   *Naphthalenes *Pyrones Phospholipases A/antagonists & inhibitors. Adv Exp Med Biol 1997;407:99-103
6-bromo-2-(1-naphthyl)-5-oxohexanoic acid  0   *Hexanoic Acids *Naphthalenes Phospholipases A/antagonists & inhibitors. Adv Exp Med Biol 1997;407:99-103
6-(2-(2-carboxyethyl)-4--dodecanoyl-3,5-dimethylpyrrol-1-yl)nonanoic acid  0   *Fatty Acids *Pyrroles Phospholipases A/antagonists & inhibitors. J Med Chem 1997 Oct 10;40(21):3381-92
6-(2-(2-carboxyethyl)-4-dodecanoyl-3,5-dimethylpyrrol-1-yl)hexanoic acid  0   *Hexanoic Acids *Pyrroles Phospholipases A/antagonists & inhibitors. J Med Chem 1997 Oct 10;40(21):3381-92
1-(4'-methoxybenzoyl)-2-n-tridecylpiperazine  0   *Piperazines Phospholipases A/antagonists & inhibitors. J Lipid Mediat Cell Signal 1997 Jul;16(3):171-87
PX 13  0   *Alkanesulfonates Phospholipases A/antagonists & inhibitors. Dig Dis Sci 1997 May;42(5):972-81
morelloflavone  16851-21-1   *Biflavonoids Phospholipases A/antagonists & inhibitors. Biochem Pharmacol 1997 Mar 7;53(5):733-40
methyl arachidonylfluorophosphonate  0   *Arachidonic Acids *Phosphonic Acids Phospholipases A/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors 		J Biol Chem 1997 Feb 7;272(6):3231-7
dehydrotumulosic acid  6754-16-1   *Triterpenes Phospholipases A/antagonists & inhibitors. J Nat Prod 1996 Oct;59(10):977-9
pachymic acid  29070-92-6   *Triterpenes Phospholipases A/antagonists & inhibitors. J Nat Prod 1996 Oct;59(10):977-9
BM 16.2224  0   *Dibenzoxepins Phospholipases A/antagonists & inhibitors. Biochim Biophys Acta 1996 May 20;1300(3):197-202
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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