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Eicosapentaenoic Acid

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Definition: Important polyunsaturated fatty acid found in fish oils. It serves as the precursor for the prostaglandin-3 and thromboxane-3 families. A diet rich in eicosapentaenoic acid lowers serum lipid concentration, reduces incidence of cardiovascular disorders, prevents platelet aggregation, and inhibits arachidonic acid conversion into the thromboxane-2 and prostaglandin-2 families.      Other names 5,8,11,14,17-Eicosapentaenoic Acid; omega 3 Eicosapentaenoic Acid; Acid, Eicosapentanoic; omega-3-Eicosapentaenoic Acid; Timnodonic Acid; Eicosapentanoic Acid; 5,8,11,14,17-Icosapentaenoic Acid
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
18(R)-hydroxyeicosapentaenoic acid  0   Eicosapentaenoic Acid/*analogs & derivatives. J Org Chem. 2011 Jul 1;76(13):5433-7
EFF1009  0   *Eicosapentaenoic Acid *gamma-Linolenic Acid Asthma/diet therapy Food, Fortified. Curr Med Res Opin. 2009 Dec;25(12):2865-75
resolvin E2  0   Eicosapentaenoic Acid/*analogs & derivatives. Chem Biol 2006 Nov;13(11):1193-202
meglumine-eicosapentaenoic acid formulation  0   *Meglumine *Eicosapentaenoic Acid Drug Combinations. Prostaglandins Leukot Essent Fatty Acids 2006 Dec;75(6):367-73
8,12-iso-iPF3alpha-VI  0   *Isoprostanes Eicosapentaenoic Acid/*analogs & derivatives. J Org Chem. 2006 Feb 17;71(4):1370-9
8,13-dihydroxyeicosapentaenoic acid  0   Eicosapentaenoic Acid/*analogs & derivatives. J Exp Biol 2006 Feb;209(Pt 3):558-66
eicosapentaenoic acid ethanolamide  0   Eicosapentaenoic Acid/*analogs & derivatives.
5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-eicosapentaenoic acid  0   Eicosapentaenoic Acid/*analogs & derivatives. J Exp Med. 2005 Mar 7;201(5):713-22
ethyl eicosapentaenoic acid  0   Eicosapentaenoic Acid/*analogs & derivatives. Mol Psychiatry 2004 Jun;9(6):630-8
eicosapentaenoate-lipoate  0   Thioctic Acid/*analogs & derivatives Eicosapentaenoic Acid/*analogs & derivatives. Prostaglandins Leukot Essent Fatty Acids 2001 Nov-dec;65(5-6):265-70
eicosapentaenoic acid diester  0   Eicosapentaenoic Acid/*analogs & derivatives. J Drug Target. 2000;8(4):247-56
Omacor  0   *Docosahexaenoic Acids *Eicosapentaenoic Acid Drug Combinations. Atherosclerosis 1999 Feb;148(2):387-96OMACOR; LOVAZA
purepa  0   *Docosahexaenoic Acids *Eicosapentaenoic Acid Drug Combinations. Drugs R D 1999 Mar;1(3):268-9
gamma-linolenoyl-3-eicosapentaenoylpropanediol  0   Eicosapentaenoic Acid/*analogs & derivatives gamma-Linolenic Acid/*analogs & derivatives. Anticancer Res 1999 May-Jun;19(3A):2041-8
EPACOCF3  0   Eicosapentaenoic Acid/*analogs & derivatives Phospholipases A/antagonists & inhibitors. J Immunol 1998 Oct 1;161(7):3421-30
LSL 90202  0   Eicosapentaenoic Acid/*analogs & derivatives. Nephron 1995;69(3):318-22
So 1129  0   *Linoleic Acids *Eicosapentaenoic Acid. Cell Prolif 1995 Feb;28(2):73-84
So 5407  160500-36-7 So 5407  *Linoleic Acids *Eicosapentaenoic Acid *gamma-Linolenic Acid. Int J Radiat Oncol Biol Phys 1994 Dec 1;30(5):1119-25
Angiosan  132698-06-7   *Docosahexaenoic Acids Drug Combinations Eicosapentaenoic Acid/*analogs & derivatives. J Int Med Res 1990;18(1):68
12,13-dihydroxyeicosa-5,8,10,14,17-pentaenoic acid  121979-38-2   Eicosapentaenoic Acid/*analogs & derivatives. Lipids 1989;24(4):256
15-hydroxy-5,8,11,13,17-eicosapentaenoic acid  97850-14-1   Eicosapentaenoic Acid/*analogs & derivatives. Biomed Environ Mass Spectrom 1988;17(6):459
5-hydroxy-6,8,11,14,17-eicosapentaenoic acid  83952-40-3   Eicosapentaenoic Acid/*analogs & derivatives. Am J Pathol 1989;134(3):671
5,8,11,14,19-eicosapentaenoic acid  111219-92-2   Eicosapentaenoic Acid/*analogs & derivatives. Prostaglandins 1987;34(1):3
5,7,9,14,17-eicosapentaenoic acid  108526-93-8   Eicosapentaenoic Acid/*analogs & derivatives. Lipids 1987;22(3):190
12-hydroperoxy-5,8,11,14,17-eicosapentaenoic acid  101973-23-3   Eicosapentaenoic Acid/*analogs & derivatives. Thromb Res 1986;41(3):373
Maxepa  0   *Docosahexaenoic Acids *Eicosapentaenoic Acid Drug Combinations Dietary Fats, Unsaturated Fish Oils. Atherosclerosis 1985;54(1):75
15-hydroperoxy-5,8,11,14,17-eicosapentaenoic acid  99901-15-2 5,8,11,14,17-Eicosapentaenoic acid, 15-hydroperoxy-, (E,Z,Z,Z,Z)  Eicosapentaenoic Acid/*analogs & derivatives. Biochem Biophys Res Commun 1985;126(2):763
leukotriene B5  80445-66-5   Leukotriene B4/*analogs & derivatives Eicosapentaenoic Acid/*analogs & derivatives. Biochem Biophys Res Commun 1983;117(1):282
eicosapentaenoic acid ethyl ester  73310-10-8   Eicosapentaenoic Acid/*analogs & derivatives.
Pharma Action Platelet Aggregation Inhibitors 		Prostaglandins 1982;23(4):557
12-hydroxy-5,8,10,14,17-eicospentaenoic acid  74838-73-6 5,8,10,14,17-Eicosapentaenoic acid, 12-hydroxy  Eicosapentaenoic Acid/*analogs & derivatives. Biochim Biophys Acta 1980;618(3):389
leukotriene C-5  75207-09-9 Glycine, N-(S-(1-(4-carboxy-1-hydroxybutyl)-2,4,6,9,12-pentadecapentaenyl)-N-L-gamma-glutamyl-L-cysteinyl)-, (R-(R*,S*-(E,E,Z,Z,Z)))  SRS-A/*analogs & derivatives Eicosapentaenoic Acid/*analogs & derivatives Autacoids. J Biol Chem 1980;255(15):7093

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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