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Autacoids
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Definition
: A chemically diverse group of substances produced by various tissues in the body that cause slow contraction of smooth muscle; they have other intense but varied pharmacologic activities.
slow-reacting substances: note X ref; GEN or unspecified; prefer specifics
Examples
Angiotensins
;
Eicosanoids
;
Histamine
;
Kinins
;
Platelet Activating Factor
;
Serotonin
Other names
Slow-
Reacting Substances; Substances, Slow-
Reacting; Slow Reacting Substances
Substance
CAS Registry & name
Categories
Source
Drugs
*
leukotriene D-
3
77165-74-3 Glycine, N-
(S-
(1-
(4-
carboxy-
1-
hydroxybutyl)-
2,4,6-
pentadecatrienyl)-
L-
cysteinyl)-
, (R-
(R*,S*-
(E,E,Z)))
SRS-A/*analogs & derivatives
Autacoids.
J Biol Chem 1981;256(5):2275
leukotriene C-
3
77209-77-9 Glycine, N-
(S-
(1-
(4-
carboxy-
1-
hydroxybutyl)-
2,4,6-
pentadecatrienyl)-
N-
L-
gamma-
glutamyl-
L-
cysteinyl)-
, (R-
(R*,S*-
(E,E,Z)))
SRS-A/*analogs & derivatives
Autacoids.
J Biol Chem 1981;256(5):2275
lysyl-
phenylalanyl-
isoleucyl-
glycyl-
leucyl-
methioninamide
2990-43-4
*Oligopeptides
Autacoids.
Acta Biol Med Ger 1980;39(1):141
leukotriene C-
5
75207-09-9 Glycine, N-
(S-
(1-
(4-
carboxy-
1-
hydroxybutyl)-
2,4,6,9,12-
pentadecapentaenyl)-
N-
L-
gamma-
glutamyl-
L-
cysteinyl)-
, (R-
(R*,S*-
(E,E,Z,Z,Z)))
SRS-A/*analogs & derivatives
Eicosapentaenoic Acid/*analogs & derivatives
Autacoids.
J Biol Chem 1980;255(15):7093
leukotriene C-
2
74841-69-3 Glycine, N-
(S-
(1-
(4-
carboxy-
1-
hydroxybutyl)-
2,4,6,9-
pentadecatetraenyl)-
N-
L-
gamma-
glutamyl-
L-
cysteinyl)-
, (R-
(R*,S*-
(E,E,E,Z)))
SRS-A/*analogs & derivatives
Autacoids.
Biochem Biophys Res Commun 1980;94(4):1133
substance P-
like peptides
0
*Peptides
Autacoids
Substance P.
Acta Physiol Pol 28(5):397;1977