Definition: The major metabolite in neutrophil polymorphonuclear leukocytes. It stimulates polymorphonuclear cell function (degranulation, formation of oxygen-centered free radicals, arachidonic acid release, and metabolism). (From Dictionary of Prostaglandins and Related Compounds, 1990)
/biosyn /physiol permitted; DF: note short X ref
Other names 5,12-diHETE; 5,12-HETE; LTB4; Leukotriene B 4; B-4, Leukotriene; 5,12 diHETE; Leukotrienes B; Leukotriene B-4; Leukotriene B; 5,12 HETE