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Crotalid Venoms

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Definition: Venoms from snakes of the subfamily Crotalinae or pit vipers, found mostly in the Americas. They include the rattlesnake, cottonmouth, fer-de-lance, bushmaster, and American copperhead. Their venoms contain nontoxic proteins, cardio-, hemo-, cyto-, and neurotoxins, and many enzymes, especially phospholipases A. Many of the toxins have been characterized.  from pit vipers (rattlesnake, cottonmouth, etc.); /antag permitted but consider also ANTIVENINS; /enzymology permitted; TN 241: common & scientific names of various crotalids   
Examples Ancrod; Batroxobin; Crotoxin 		Other names Rattlesnake Venoms; Pit Viper Venoms; Viper Venom, Pit; Venoms, Rattlesnake; Venoms, Pit Viper; Venoms, Crotalid; Venom, Rattlesnake; Venom, Pit Viper; Venom, Crotaline Snake; Venom, Crotalid; Snake Venom, Crotaline; Rattlesnake Venom; Pit Viper Venom; Crotamin; Crotalotoxin; Crotaline Snake Venom; Crotalin; Crotalid Venom; Crotactin
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
porthidin-1, Porthidium lansbergii hutmanni  EC 3.4.-   *Crotalid Venoms *Metalloproteases. Toxicon. 2011 Mar 15;57(4):608-18
insularin, Bothrops insularis  0   *Crotalid Venoms *Disintegrins. Toxicon. 2011 Jan;57(1):125-33
jerdonuxin, Trimeresurus jerdoni  0   *Crotalid Venoms *Lectins, C-Type. Toxicon. 2011 Jan;57(1):109-16
Batx-I, Bothrops atrox  EC 3.4.-   *Crotalid Venoms *Metalloproteases. Toxicon. 2010 Nov;56(6):936-43
acurhagin-C protein, Agkistrodon acutus  0   *Peptide Fragments *Disintegrins Crotalid Venoms. Br J Pharmacol 2010 Jul;160(6):1338-51
purpurase protein, Cryptelytrops purpureomaculatus  EC 3.4.-   *Crotalid Venoms *Endopeptidases. Comp Biochem Physiol C Toxicol Pharmacol 2010 Jan;151(1):131-6
CDC-10 protein, Crotalus durissus  EC 3.1.1.4   *Crotalid Venoms *Phospholipases A2. Comp Biochem Physiol C Toxicol Pharmacol 2010 Jan;151(1):66-74
CDC-9 protein, Crotalus durissus  EC 3.1.1.4   *Crotalid Venoms *Phospholipases A2. Comp Biochem Physiol C Toxicol Pharmacol 2010 Jan;151(1):66-74
brazilitoxin III, Bothrops brazili  EC 3.1.1.4   *Crotalid Venoms *Phospholipases A2. Toxicon 2009 Nov;54(6):818-27
brazilitoxin II, Bothrops brazili  EC 3.1.1.4   *Crotalid Venoms *Phospholipases A2. Toxicon 2009 Nov;54(6):818-27
Lys49-phospholipase A2, Bothrops lternatus  EC 3.1.1.-   *Crotalid Venoms *Phospholipases A2. Comp Biochem Physiol C Toxicol Pharmacol. 2009 Aug;150(2):291-7
HF3 protein, Bothrops jararaca  EC 3.4.24.-   *Crotalid Venoms *Metalloproteases. Toxicon. 2009 Jun;53(7-8):797-801
chitribrisin, Trimeresurus albolabris  EC 3.4.21.5   *Crotalid Venoms *Thrombin. Protein Expr Purif 2009 Sep;67(1):48-52
hellerase, Crotalus oreganus helleri  EC 3.4.-   *Crotalid Venoms *Metalloproteases. Comp Biochem Physiol C Toxicol Pharmacol 2009 Apr;149(3):307-16
cumanastatin 1, Crotalus durissus cumanensis  0   *Crotalid Venoms *Disintegrins. Thromb Res 2009 Mar;123(5):731-9
thrombin-like protein, Agkistrodon acutus  EC 3.4.21.5   *Crotalid Venoms *Thrombin. Zhongguo Shi Yan Xue Ye Xue Za Zhi 2005 Aug;13(4):542-7
Cr-IV 1 myotoxin, Calloselasma rhodostoma  EC 3.1.1.4   *Crotalid Venoms *Phospholipases A2. Biologicals 2008 May;36(3):168-76
trowaglerix protein, Tropidolaemus wagleri  0   *Crotalid Venoms *Lectins, C-Type. J Thromb Haemost 2008 Apr;6(4):669-76
albolatin, Trimeresurus albolabris  EC 3.4.-   *Crotalid Venoms *Metalloproteases. Toxicon 2007 Dec 15;50(8):1192-200
crotarhagin, Crotalus horridus horridus  EC 3.4.24.-   *Crotalid Venoms *Metalloproteases. Thromb Haemost 2007 Dec;98(6):1285-90
ACTX-6 protein, Agkistrodon acutus  0   *Crotalid Venoms. Toxicol In Vitro 2007 Sep;21(6):1095-103
kistomin protein, Calloselasma rhodostoma  EC 3.4.-   *Crotalid Venoms *Metalloproteases. Mol Pharmacol 2007 Oct;72(4):984-92
Cdr-13 protein, Crotalus durissus ruruima  EC 3.1.1.4   *Crotalid Venoms *Phospholipases A. Protein J 2007 Jan;26(1):39-49
Cdr-12 protein, Crotalus durissus ruruima  EC 3.1.1.4   *Crotalid Venoms *Phospholipases A. Protein J 2007 Jan;26(1):39-49
leucurobin, Bothrops leucurus  EC 3.4.21.5   *Crotalid Venoms *Thrombin. Comp Biochem Physiol A Mol Integr Physiol 2007 Apr;146(4):565-75
pEM-2D peptide  0   *Peptide Fragments Crotalid Venoms. Cell Biol Int 2007 Mar;31(3):263-8
p-AppK peptide  0   *Peptide Fragments Crotalid Venoms. Cell Biol Int 2007 Mar;31(3):263-8
ACTX-8 protein, Agkistrodon acutus  0   *Crotalid Venoms. Life Sci 2007 Mar 6;80(13):1189-97
Canova medication  0   *Crotalid Venoms *Plant Extracts Formularies, Homeopathic. J Infect 2005 Aug;51(2):157-64
BE-I-PLA2 protein, Bothrops erythromelas  EC 3.1.1.4   *Reptilian Proteins *Group II Phospholipases A2 Crotalid Venoms. Biochem Pharmacol 2006 Jul 28;72(3):377-84
crotacetin beta-subunit, Crotalus durissus terrificus  0   *Crotalid Venoms *Lectins, C-Type. Cell Biochem Biophys 2006;44(3):412-23
VAP2 protein, Crotalus atrox  EC 3.4.24.-   *Crotalid Venoms *Metalloendopeptidases. Eur J Biochem 1998 Apr 1;253(1):36-41
cotiaractivase, Bothrops cotiara  0   *Crotalid Venoms Metalloproteases. Biochim Biophys Acta 2006 May;1764(5):863-71
TM-N49 protein, Protobothrops mucrosquamatus  EC 3.1.1.4   *Reptilian Proteins *Group II Phospholipases A2 Crotalid Venoms. Biochim Biophys Acta 2006 Mar;1760(3):462-71
acutobin, Deinagkistrodon acutus  EC 3.4.21.5   *Crotalid Venoms *Thrombin. Brain Res 2004 Oct 1;1022(1-2):234-43
halysase, Gloydius halys  EC 3.4.24.-   *Crotalid Venoms *Metalloendopeptidases. J Biochem (Tokyo) 2003 Nov;134(5):739-49
insularinase A, Bothrops insularis  EC 3.4.-   *Crotalid Venoms *Metalloproteases Prothrombin/agonists. Biol Chem 2005 Jun;386(6):589-600
berythractivase, Bothrops erythromelas  EC 3.4.24.-   *Crotalid Venoms *Metalloendopeptidases. Biol Chem 2005 Apr;386(4):369-74
triflin protein, Trimeresurus flavoviridis  0   *Crotalid Venoms. J Mol Biol 2005 Jul 22;350(4):735-43
KN-BJ2 protein, Bothrops jararaca  EC 3.4.21.-   *Crotalid Venoms *Serine Endopeptidases. Protein Sci 2004 Sep;13(9):2355-69
BJcuL lectin, Bothrops jararacussu  0   *Crotalid Venoms *Lectins, C-Type. Protein Expr Purif 2004 Jun;35(2):344-52
stecrisp protein, Trimeresurus stejnegeri  0   *Crotalid Venoms. Acta Crystallogr D Biol Crystallogr 2004 Jun;60(Pt 6):1108-11
adinbitor protein, Agkistrodon halys brevicaudus stejneger  0   *Crotalid Venoms *Disintegrins. Acta Biochim Biophys Sin (Shanghai) 2004 Jun;36(6):425-9
agkislysin, Agkistrodon acutus  EC 3.4.-   *Crotalid Venoms *Metalloproteases. Biochem Biophys Res Commun 2004 Nov 5;324(1):224-30
triflamp, Trimeresurus flavoviridis  EC 3.4.-   *Crotalid Venoms *Metalloproteases. Thromb Haemost 2004 Feb;91(2);315-24
ACL myotoxin, A contortrix  EC 3.1.1.4   *Reptilian Proteins *Group II Phospholipases A2 Crotalid Venoms Neurotoxins. Toxicon. 2004 Jan;43(1):77-83
PO41 venom, Philander opossum  0   *Crotalid Venoms. Toxicon 2003 Nov;42(6):621-8
jerdonase, Trimeresurus jerdonii  EC 3.4.21.-   *Crotalid Venoms *Serine Endopeptidases. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 2003 Aug;35(8):689-94
jerdofibrase, Trimeresurus jerdonii  EC 3.4.21.-   *Crotalid Venoms *Serine Endopeptidases. Comp Biochem Physiol B Biochem Mol Biol 2002 Jul;132(3):529-34
jerdonobin, Trimeresurus jerdonii  EC 3.4.21.-   *Crotalid Venoms *Serine Endopeptidases. Comp Biochem Physiol B Biochem Mol Biol 2002 Jul;132(3):529-34
BnSP-6  EC 3.1.1.-   *Crotalid Venoms *Phospholipases A2. Biochem Biophys Res Commun 2003 Nov 21;311(3):713-20
FIIa  0   *Crotalid Venoms. Acta Pharmacol Sin 2001 May;22(5):420-2
basparin A, Bothrops asper  EC 3.4.24.-   *Crotalid Venoms *Metalloendopeptidases. Arch Biochem Biophys 2003 Oct 1;418(1):13-24
calglandulin, Bothrops insularis  0   *Crotalid Venoms. Biochim Biophys Acta 2003 May 30;1648(1-2):90-8
alpha-mucrofibrase, Trimeresurus mucrosquamatus  EC 3.4.21.-   *Crotalid Venoms *Serine Endopeptidases. J Nat Toxins 2002 Dec;11(4):337-43
agkistin, Agkistrodon halys  EC 3.4.24.-   *Crotalid Venoms *Metalloendopeptidases. Biochem Biophys Res Commun 2003 Feb 7;301(2):298-303
bilinexin, Agkistrodon bilineatus  0   *Crotalid Venoms *Lectins, C-Type. Thromb Haemost 2001 Nov;86(5):1277-83
myotoxin inhibitor protein, Bothrops moojeni  0   *Crotalid Venoms. Biochem Biophys Res Commun 2003 Mar 7;302(2):193-200
bothropasin, Bothrops jararaca  EC 3.4.24.-   *Crotalid Venoms *Metalloendopeptidases. Toxicon 2003 Feb;41(2):217-27
halyxin, Agkistrodon halys brevicaudus  0   *Crotalid Venoms. Toxicon 2002 Jul;40(7):947-57
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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