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Neurotoxins

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Definition: Toxic substances from microorganisms, plants or animals that interfere with the functions of the nervous system. Most venoms contain neurotoxic substances. Myotoxins are included in this concept.  /antag permitted but consider also ANTITOXINS; coordinate IM with toxin or venom heading which is the source of the neurotoxin (IM or NIM); do not use for neurotoxicity of various chemicals & drugs (   
See Also Neurotransmitter Agents 		Other names Excitotoxins; Neurotoxins, Excitatory; Alpha Neurotoxins; Excitotoxin; Excitatory Neurotoxins; Alpha-Neurotoxins
Substances having this pharmacologic action: pardaxin; omega-Conotoxin GVIA; omega-Agatoxin IVA; harman; Conotoxins; omega-Conotoxins; tryptoline; Agatoxins; amiton; norharman; Tetanus Toxin; Charybdotoxin; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Botulinum Toxins, Type A; Methylazoxymethanol Acetate; Cobra Neurotoxin Proteins; Cycasin; 3-acetylpyridine; 2,5-hexanedione; N-acetyl-1-aspartylglutamic acid
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
helicopsin, Helicops angulatus  0   *Snake Venoms Neurotoxins. Arch Toxicol. 2011 Apr;85(4):305-13
alpha-elapitoxin-Aa2a, Acanthophis antarcticus  0   *Elapid Venoms Neurotoxins. Biochem Pharmacol 2011 Jan 15;81(2):314-25
GxTX-1E, Plesiophrictus guangxiensis  0   *Peptides *Spider Venoms Neurotoxins. Biochemistry. 2010 Jun 29;49(25):5134-42
PV2 protein, Pomacea canaliculata  0   *Mollusk Venoms Neurotoxins. Biochim Biophys Acta. 2010 Jul;1804(7):1492-9
alpha-oxytoxin 1, Oxyuranus scutellatus canni  0   *Elapid Venoms Neurotoxins. Neurotoxicology. 2010 Mar;31(2):239-43
alpha-scutoxin 1, Oxyuranus scutellatus scutellatus  0   *Elapid Venoms Neurotoxins. Neurotoxicology. 2010 Mar;31(2):239-43
anntoxin, Hyla annectans  0   *Amphibian Proteins Neurotoxins. J Biol Chem. 2009 Aug 14;284(33):22079-86
paradoxin  0   *Elapid Venoms Neurotoxins. Neuropharmacology. 2007 Apr;52(5):1229-36
PRTx3-7 toxin  0   *Spider Venoms Neurotoxins. Cell Mol Neurobiol. 2007 Feb;27(1):129-46
AamTX protein, Androctonus amoreuxi  0   *Scorpion Venoms *Insect Proteins Neurotoxins Potassium Channel Blockers. Peptides 2005 May;26(5):731-6
boigatoxin A  0   Snake Venoms Neurotoxins. Toxicon. 2005 Mar 1;45(3):329-34
BrMT neurotoxin, Calliostoma canaliculatum  0   *Tryptamines Neurotoxins. J Nat Prod 2005 Feb;68(2);162-7
AvTx8 neurotoxin  0   *Wasp Venoms Neurotoxins. Brain Res. 2005 Jan 7;1031(1):74-81
BmKK4 neurotoxin, Buthus martensii  0   Scorpion Venoms Neurotoxins. Peptides. 2004 Jun;25(6):951-7
BmTx3B, Buthus  0   *Scorpion Venoms Neurotoxins. Acta Pharmacol Sin. 2003 Oct;24(10):1016-20
toxin alpha, Tityus cambridgei  0   Scorpion Venoms Neurotoxins. Toxicon. 2004 May;43(6):737-40
toxin beta, Tityus zulianus  0   Scorpion Venoms Neurotoxins. Toxicon. 2004 May;43(6):671-84
Ts3 toxin, Tityus serrulatus  0   *Scorpion Venoms Neurotoxins. FASEB J 2003 mar;17(3):485-7
ACL myotoxin, A contortrix  EC 3.1.1.4   *Reptilian Proteins *Group II Phospholipases A2 Crotalid Venoms Neurotoxins. Toxicon. 2004 Jan;43(1):77-83
TsTX-I, mouse  0   *Scorpion Venoms Neurotoxins. Int Immunopharmacol. 2003 May;3(5):765-74
atratoxin-b  0   Cobra Venoms Insect Proteins Neurotoxins. Acta Crystallogr D Biol Crystallogr. 2003 Jun;59(Pt 6):1038-42
huwentoxin-V, Selenocosmia huwena  0   *Spider Venoms Neurotoxins. Toxicon 2003 Jul;42(1);15-20
mikatoxin, Micropechis ikaheka  0   *Snake Venoms Neurotoxins. Toxicon 2002 Jul;40(7):863-71
AngP1 neurotoxin  0   Organic Chemicals Neurotoxins. J Pept Res 2001 Jul;58(1):27-35
Bs-dprIT1 protein, Mesobuthus tamulus sindicus  0   *Insect Proteins Scorpion Venoms Neurotoxins. Arch Biochem Biophys 2001 Jul 15;391(2):197-206
WTX toxin  0   *Reptilian Proteins Cobra Venoms Neurotoxins. Bioorg Khim 2001 Mar-Apr;27(2):89-101
bukatoxin  0   Scorpion Venoms Insect Proteins Neurotoxins. FEBS Lett 2001 Apr 13; 494(3):145-9
bucandin  0   *Elapid Venoms Neurotoxins. Acta Crystallogr D Biol Crystallogr 2000 Nov;56( Pt 11):1401-7
CSTX-2a protein, Cupiennius salei  0   *Spider Venoms Neurotoxins. Arch Insect Biochem Physiol 2000 Jul;44(3):101-11
sntx1 protein, Pseudonaja textilis  0   *Elapid Venoms *Reptilian Proteins Neurotoxins. FEBS Lett 2000 May 19;473(3):303-10
scorpion neurotoxin BmK M2  0   *Scorpion Venoms Neurotoxins. Acta Crystallogr D Biol Crystallogr 2000 Jan;56 ( Pt 1):25-33
BmK M8 neurotoxin  0   *Scorpion Venoms Neurotoxins. J Nat Toxins 1999 Oct;8(3):309-25
BmK M4 neurotoxin  0   *Scorpion Venoms *Insect Proteins Neurotoxins. J Nat Toxins 1999 Oct;8(3):309-25
BmK M1 neurotoxin  0   *Scorpion Venoms *Insect Proteins Neurotoxins. J Nat Toxins 1999 Oct;8(3):309-25
neurotoxin Os3 protein, Orthochirus scrobiculosus  0   *Peptides *Scorpion Venoms Neurotoxins. Bioorg Khim 1999 May;25(5):341-7
scorpion toxin Ts1, Tityus  0   *Scorpion Venoms *Insect Proteins Neurotoxins. J Mol Biol 1999 Jul 2;290(1):175-84
tityustoxin IV  0   *Scorpion Venoms Neurotoxins. Toxicon 1999 Apr;37(4):651-60
Ts-gamma neurotoxin  0   Scorpion Venoms Neurotoxins. Acta Crystallogr D Biol Crystallogr 1998 Nov 1;54(2( Pt 6)):1440-1
kurtoxin  0   *Scorpion Venoms Neurotoxins. Nat Neurosci 1998 Dec;1(8):668-74
scorpion toxin Aah VI  0   *Scorpion Venoms Neurotoxins. FEBS Lett 1999 Jan 25;443(2):175-80
scorpion toxin CsE-I  0   *Scorpion Venoms Neurotoxins. Biochem Biophys Res Commun 1999 Jan 19;254(2):406-12
Bj-xtrIT toxin  0   *Insect Proteins Neurotoxins. Structure 1998 Sep 15;6(9):1095-103
pompilidotoxin beta  0   *Insect Proteins Wasp Venoms Neurotoxins. Biochem Biophys Res Commun 1998 Sep 29;250(3):612-6
pompilidotoxin alpha  0   *Insect Proteins Wasp Venoms Neurotoxins. Biochem Biophys Res Commun 1998 Sep 29;250(3):612-6
cobatoxin 2  0   *Scorpion Venoms Neurotoxins. Eur J Biochem 1998 Jun 15;254(3):468-79
cobatoxin 1  0   *Scorpion Venoms Neurotoxins. Eur J Biochem 1998 Jun 15;254(3):468-79
myotoxin II, Bothrops godmani  EC 3.1.1.4   *Reptilian Proteins *Group II Phospholipases A2 Crotalid Venoms Neurotoxins. Biochim Biophys Acta 1998 May 19;1384(2):204-8
LqhIT5 toxin, Leiurus quinquestriatus hebraeus  0   *Scorpion Venoms Neurotoxins. Eur J Biochem 1998 May 15;254(1):44-9
LqhIT1 insect toxin  0   *Scorpion Venoms Recombinant Proteins Neurotoxins. FEBS Lett 1998 Jan 30;422(2):132-6
gamma-conotoxin PnVIIA  0   *Conotoxins Neurotoxins. Biochemistry 1998 Feb 10;37(6):1470-7
hongotoxin 1  0   *Scorpion Venoms Neurotoxins. J Biol Chem 1998 Jan 30;273(5):2639-44
TX1 toxin, Buthus  0   *Scorpion Venoms Neurotoxins Potassium Channels/antagonists & inhibitors. Biochemistry 1997 Nov 4;36(44):13473-82
KTX toxin, Buthus  0   *Scorpion Venoms Neurotoxins. Biochemistry 1997 Nov 4;36(44):13473-82
kappa-conotoxin PVIIA  0   *Conotoxins Neurotoxins Potassium Channels/antagonists & inhibitors. J Neurosci 1997 Nov 1;17(21):8213-24
CRVP protein, Trimeresurus mucrosquamatus  0   *Crotalid Venoms *Reptilian Proteins Neurotoxins. Toxicon 1997 Jun;35(6):879-88
Lqh 8-6 protein, Leiurus quinquestriatus hebraeus  0   *Scorpion Venoms *Insect Proteins Neurotoxins. Eur J Biochem 1997 May 15;246(1):218-27
toxin Aa e, Acanthophis  0   *Elapid Venoms Neurotoxins. Toxicon 1997 Apr;35(4):555-62
halcurin  0   *Cnidarian Venoms Neurotoxins Sea Anemones. Toxicon 1997 Apr;35(4):537-44
CM-VI toxin  0   *Scorpion Venoms Neurotoxins. Biochem Mol Biol Int 1996 Jul;39(4):729-40
oxalyldiaminopropionic acid  7554-90-7 Alanine, 3-((carboxycarbonyl)amino)  *Amino Acids, Diamino Lathyrism Neurotoxins.
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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